Polymorphisms in the Genes Encoding TGF-β1, TNF-α, and IL-6 Show Association with Type 1 Diabetes Mellitus in the Slovak Population

ObjectiveWe examined the relationship of inflammatory and endothelial dysfunction markers with the prevalence and incidence of gross proteinuria (GP) in persons with type 1 diabetes mellitus.DesignA longitudinal population-based cohort of persons with type 1 diabetes mellitus was followed from 1990–1992 through 2005–2007.MethodsPrevalence and 15-year cumulative incidence of GP were defined as outcome variables. Serum high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), soluble vascular cell adhesion molecule-1 (VCAM-1), soluble intercellular adhesion molecule-1, and serum total homocysteine were measured. Multivariate logistic and discrete linear logistic regression modeling was used for data analysis.ResultsAfter controlling for duration of diabetes and other confounding factors, TNF-α (odds ratio (OR) 3.64; 95% confidence interval (CI) 2.33, 5.70), IL-6 (OR 1.41; 95% CI 1.06, 1.88), VCAM-1 (OR 13.35; 95% CI 5.39, 33.07), and homocysteine (OR 2.98; 95% CI 1.73, 5.16) were associated with prevalent proteinuria. Only hsCRP (OR 1.47; 95% CI 1.02, 2.11) was associated with incident proteinuria.ConclusionsThese findings suggest a role of inflammation and endothelial dysfunction as markers and contributors of the development of diabetic nephropathy in persons with type 1 diabetes mellitus.

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Studying Studying the relationship between Dipeptidyl peptidase-4 enzyme level, Tumor necrosis factor alpha enzyme level, and insulin resistance in type 1 Diabetes Mellitus patients

QJM ◽

10.1093/qjmed/hcaa052.042 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

H M Amer ◽

M M M Mahdy ◽

W E Saad ◽

M N A Abdelsalam

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Serum Level ◽

Type 1 Diabetes Mellitus ◽

Enzyme Level ◽

Venous Blood ◽

P Value ◽

Tnf Α ◽

The Relationship

Abstract Background Type 1 diabetes mellitus (T1DM) is an inflammatory disease of the pancreatic islets that results in absolute insulin deficiency and the consecutive hyperglycemia due to immune-mediated beta cell destruction throughout the globe, the incidence of T1DM is increasing at 3% to 5% per year Purpose To study the relationship between DPP-4 serum level, TNF a concentration measurements, and insulin sensitivity in T1DM patient Patients and Methods Patients were selected from the inpatient department of National Institute of Diabetes and Endocrinology during Januaray 2017, venous blood samples were collected to measure Serum level of creatinine, C-peptide, HbA1c%, DPP-4, TNFα . Measurement of eGDR was done using the formula 24.31 - 12.2 x (WHR) – 3.29 x (BLP) – 0.57 X HbA1c Study Design Cross sectional study that included 80 patients with type 1 Diabetes, Results The study population was divided according to median eGDR value of 6.125 mg kg-1 min-1 The group with higher IR(eGDR≤ 6.125)had higher value of DPP-4 enzyme level (1127.3 ± 40.9 ng/ml vs. 870.6 ± 30.2 ng/ml, p < 0.001) and TNF α concentration (11.4 ± 4.8 pg/ml vs 5.3 ± 1.6 pg/ml, p < 0.001). TNF α concentration negatively correlated with eGDR (r= -0.515, p value <0.001) DPP-4 level negatively correlated with eGDR (r= -0.826 and p value <0.001) while DPP-4 was positively correlated with TNF α (r = 0.441 p value ≤ 0.001)

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Cardioprotective effect of pioglitazone and curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus: impact on CaMKII/NF-κB/TGF-β1 and PPAR-γ signaling pathway

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-020-01979-y ◽

2020 ◽

Author(s):

Aya A. Gbr ◽

Nayira A. Abdel Baky ◽

Eman A. Mohamed ◽

Heba S. Zaky

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Signaling Pathway ◽

Diabetic Cardiomyopathy ◽

Cardioprotective Effect ◽

Ppar Γ ◽

Tgf Β1

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Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus

BMC Medical Genetics ◽

10.1186/1471-2350-12-129 ◽

2011 ◽

Vol 12 (1) ◽

Cited By ~ 16

Author(s):

Suzana M Vieira ◽

Maria B Monteiro ◽

Tatiana Marques ◽

Ana M Luna ◽

Maria A Fortes ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Renal Disease ◽

Type 1 Diabetes Mellitus ◽

Genetic Variants ◽

Promoter Region ◽

Catalytic Subunit ◽

Glutamate Cysteine Ligase ◽

Genes Encoding

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Associations of insulin-induced lipodystrophy in children, adolescents, and young adults with type 1 diabetes mellitus using recombinant human insulin: a cross-sectional study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0556 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Arijit Singha ◽

Rana Bhattacharjee ◽

Bibhas Saha Dalal ◽

Dibakar Biswas ◽

Subhadip Choudhuri ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Young Adults ◽

Type 1 Diabetes Mellitus ◽

Insulin Antibody ◽

Injection Technique ◽

Cross Sectional ◽

Tnf Α ◽

Antibody Levels

Abstract Objective Insulin-induced lipodystrophy is of two types, lipohypertrophy and lipoatrophy. Lipodystrophy often leads to worsening of glycemic control in type 1 diabetes mellitus. Our objective was to identify the clinical, immunological, and other factor(s) associated with the development of lipodystrophy. Methods In this observational cross-sectional hospital-based study, 95 children, adolescents, and young adults with type 1 diabetes mellitus were observed for the development of lipodystrophy. Injection technique, insulin dose, and glycemic parameters were noted. Serum TNF-α, IL-1β, and anti-insulin antibody levels were measured. Histopathological examination of the lipodystrophic area was done in a small number of people. Results Among the participants, 45.2% of participants had lipohypertrophy and 4.2% had lipoatrophy exclusively; 3.1% of participants had coexisting lipohypertrophy and lipoatrophy. Improper injection site rotation technique was more common in participants with lipohypertrophy in comparison to those without lipodystrophy. The age of onset of diabetes, duration of insulin use, and the number of times of needle reuse were not significantly different between the lipohypertrophy and nonlipodystrophy groups. Serum TNF-α, IL-1β, and anti-insulin antibody levels; HbA1c; rate of hypoglycemia; and body weight-adjusted dose requirement were higher among the participants with lipohypertrophy. On histopathology, scant, or no inflammatory infiltrate was found in lipoatrophic and lipohypertrophic areas, respectively. Conclusion Improper insulin injection technique and higher levels of proinflammatory cytokines and anti-insulin antibody are associated with lipodystrophy in type 1 diabetes mellitus. HbA1c and rate of hypoglycemia are higher in people with lipodystrophy.

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