Clomipramine, but not haloperidol or aripiprazole, inhibits quinpirole-induced water contrafreeloading, a putative animal model of compulsive behavior

2011 ◽  
Vol 218 (4) ◽  
pp. 749-759 ◽  
Author(s):  
Lorenza De Carolis ◽  
Chiara Schepisi ◽  
Michele S. Milella ◽  
Paolo Nencini
Keyword(s):  
Animal Model ◽  
Compulsive Behavior

Valproate-Induced “Wet Dog Shakes” – A Reproducible Animal Model of Human Compulsive Behavior : Effect of Antidepressants

2007 ◽  
Vol 14 (4) ◽  
pp. 93-95
Author(s):  
Prathibha E A Jose ◽  
Joy David ◽  
Vikram K Yeragani ◽  
Chanda Kulkarni
Keyword(s):  
Animal Model ◽  
Compulsive Behavior ◽  
Wet Dog Shakes

Psychostimulant-Induced Behavior as an Animal Model of Obsessive-Compulsive Disorder: An Ethological Approach to the Form of Compulsive Rituals

CNS Spectrums ◽  
2005 ◽  
Vol 10 (3) ◽  
pp. 191-202 ◽  
Author(s):  
David Eilam ◽  
Henry Szechtman
Keyword(s):  
Animal Model ◽  
Obsessive Compulsive Disorder ◽  
Rat Model ◽  
Receptor Agonist ◽  
Dopamine Receptor Agonist ◽  
Compulsive Behavior ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dopaminergic Mechanisms ◽  
Motor Acts

AbstractRats treated chronically with the D2/D3, dopamine receptor agonist quinpirole show a pattern of behavior that meets a set of ethologically derived criteria of compulsive behavior in obsessive-compulsive disorder (OCD). Moreover, in both quinpirole-treated rats and OCD patients, the structure of compulsive rituals appear similar in being composed of relatively few motor acts that are organized in a flexible yet recurrent manner. In addition, the development of compulsive behavior in quinpirole-treated rats is attenuated by the OCD pharmacotherapeutic drug clomipramine. These similarities support the validity of quinpirole-treated rats as a psychostimulant-induced animal model of OCD. Considering that the induction of compulsive behavior in the rat model involves chronic hyperstimulation of dopamine receptors, this raises the possibility that dopaminergic mechanisms may play a role in OCD, at least in some subtypes of this disorder.

B.11 - PRAMIPEXOLE DISRUPTS SYNAPTIC PLASTICITY IN THE CA1 AREA OF THE HIPOCAMPUS OF RATS THAT DEVELOP CONTRAFREELOADING FOR WATER, AN ANIMAL MODEL OF COMPULSIVE BEHAVIOR

2013 ◽  
Vol 24 ◽  
pp. e29
Author(s):  
Chiara Schepisi ◽  
Sonia Piccinin ◽  
Salvatore Simone Doronzio ◽  
Annabella Pignataro ◽  
Martine Ammassari-Teule ◽  
...  
Keyword(s):  
Animal Model ◽  
Synaptic Plasticity ◽  
Compulsive Behavior ◽  
Ca1 Area

NS.4.2 - PRAMIPEXOLE DISRUPTS SYNAPTIC PLASTICITY IN THE CA1 AREA OF THE HIPOCAMPUS OF RATS THAT DEVELOP CONTRAFREELOADING FOR WATER, AN ANIMAL MODEL OF COMPULSIVE BEHAVIOR

2013 ◽  
Vol 24 ◽  
pp. e21
Author(s):  
Chiara Schepisi ◽  
Sonia Piccinin ◽  
Salvatore Simone Doronzio ◽  
Annabella Pignataro ◽  
Martine Ammassari-Teule ◽  
...  
Keyword(s):  
Animal Model ◽  
Synaptic Plasticity ◽  
Compulsive Behavior ◽  
Ca1 Area

The role of serotonin in compulsive behavior: an animal model

1993 ◽  
Vol 3 (3) ◽  
pp. 227-228
Author(s):  
W.H. Bridger ◽  
E. Friedman ◽  
E. Yadin
Keyword(s):  
Animal Model ◽  
Compulsive Behavior

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Electron Microscopic Detection and Characterization of Nonhuman Primate Enteric Viruses

1982 ◽  
Vol 40 ◽  
pp. 306-307
Author(s):  
G. C. Smith ◽  
R. L. Heberling ◽  
S. S. Kalter
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Nonhuman Primate ◽  
Clinical Condition ◽  
Intestinal Tract ◽  
Enteric Viruses ◽  
Electron Microscopic ◽  
Microscopic Detection

A number of viral agents are recognized as and suspected of causing the clinical condition “gastroenteritis.” In our attempts to establish an animal model for studies of this entity, we have been examining the nonhuman primate to ascertain what viruses may be found in the intestinal tract of “normal” animals as well as animals with diarrhea. Several virus types including coronavirus, adenovirus, herpesvirus, and picornavirus (Table I) were detected in our colony; however, rotavirus, astrovirus, and calicivirus have not yet been observed. Fecal specimens were prepared for electron microscopy by procedures reported previously.

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

Membrane-associated microtubular areays induced in proximal myelinated processes of dorsal root ganglia by large doses of vitamin B6

1986 ◽  
Vol 44 ◽  
pp. 368-369
Author(s):  
V.J. Montpetit ◽  
S. Dancea ◽  
L. Tryphonas ◽  
D.F. Clapin
Keyword(s):  
Animal Model ◽  
Endoplasmic Reticulum ◽  
Dorsal Root Ganglia ◽  
Rough Endoplasmic Reticulum ◽  
Dorsal Root ◽  
Vitamin B6 ◽  
Morphological Changes ◽  
Model System ◽  
Sensory Nerves ◽  
Peripheral Sensory

Very large doses of pyridoxine (vitamin B6) are neurotoxic in humans, selectively affecting the peripheral sensory nerves. We have undertaken a study of the morphological and biochemical aspects of pyridoxine neurotoxicity in an animal model system. Early morphological changes in dorsal root ganglia (DRG) associated with pyridoxine megadoses include proliferation of neurofilaments, ribosomes, rough endoplasmic reticulum, and Golgi complexes. We present in this report evidence of the formation of unique aggregates of microtubules and membranes in the proximal processes of DRG which are induced by high levels of pyridoxine.

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