Theoretical study of boron nitride nanotubes as drug delivery vehicles of some anticancer drugs

2018 ◽  
Vol 137 (7) ◽  
Author(s):  
Hong Xu ◽  
Qi Wang ◽  
Guohong Fan ◽  
Xiangfeng Chu
Keyword(s):  
Drug Delivery ◽  
Boron Nitride ◽  
Anticancer Drugs ◽  
Theoretical Study ◽  
Boron Nitride Nanotubes ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

5-Aminolevulinic acid functionalized boron-nitride and carbon nanotubes as drug delivery vehicles for skin anticancer drugs: a theoretical study

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92547-92559 ◽  
Author(s):  
Pabitra Narayan Samanta ◽  
Kalyan Kumar Das
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Boron Nitride ◽  
Theoretical Study ◽  
Aminolevulinic Acid ◽  
Quantum Chemical Study ◽  
Chemical Study ◽  
Drug Molecule ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

A quantum chemical study has been made on the interaction of 5-aminolevulinic acid (ALA) drug molecule with boron-nitride and carbon nanotubes so as to use these nanomaterials as drug-delivery vehicles.

scholarly journals Encapsulation of Hydrophobic Drugs in Shell-by-Shell Coated Nanoparticles for Radio—and Chemotherapy—An In Vitro Study

2020 ◽  
Vol 7 (4) ◽  
pp. 126
Author(s):  
Stefanie Klein ◽  
Tobias Luchs ◽  
Andreas Leng ◽  
Luitpold Distel ◽  
Winfried Neuhuber ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Double Layer ◽  
Oxide Surface ◽  
Al2o3 Nanoparticles ◽  
X Rays ◽  
Hydrophobic Drugs ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Mcf 7

Our research objective was to develop novel drug delivery vehicles consisting of TiO2 and Al2O3 nanoparticles encapsulated by a bilayer shell that allows the reversible embedment of hydrophobic drugs. The first shell is formed by covalent binding of hydrophobic phosphonic acid at the metal oxide surface. The second shell composed of amphiphilic sodium dodecylbenzenesulfonate emerges by self-aggregation driven by hydrophobic interactions between the dodecylbenzene moiety and the hydrophobic first shell. The resulting double layer provides hydrophobic pockets suited for the intake of hydrophobic drugs. The nanoparticles were loaded with the anticancer drugs quercetin and 7-amino-4-methylcoumarin. Irradiation with X-rays was observed to release the potential anticancer drugs into the cytoplasm. In Michigan Cancer Foundation (MCF)-10 A cells, quercetin and 7-amino-4-methylcoumarin acted as antioxidants by protecting the non-tumorigenic cells from harmful radiation effects. In contrast, these agents increased the reactive oxygen species (ROS) formation in cancerous MCF-7 cells. Quercetin and 7-amino-4-methylcoumarin were shown to induce apoptosis via the mitochondrial pathway in cancer cells by determining an increase in TUNEL-positive cells and a decrease in mitochondrial membrane potential after irradiation. After X-ray irradiation, the survival fraction of MCF-7 cells with drug-loaded nanoparticles considerably decreased, which demonstrates the excellent performance of the double-layer stabilized nanoparticles as drug delivery vehicles.

scholarly journals Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

RSC Advances ◽  
2021 ◽  
Vol 11 (36) ◽  
pp. 22057-22069
Author(s):  
Pooja Prasanthan ◽  
Nand Kishore
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Triblock Copolymers ◽  
Target Protein ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Micelles formed by pluronic triblock copolymers are known to be a promising class of drug delivery vehicles.

Patents in chemotherapy: nanoparticles as drug-delivery vehicles

2020 ◽  
Vol 9 (4) ◽  
pp. 117-119
Author(s):  
Absar Talat ◽  
Asad U Khan
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Advanced Technology ◽  
Drug Delivery Vehicles ◽  
The World ◽  
Delivery Vehicles ◽  
Novel Methods

The high statistics of cancer cases and mortalities throughout the world signify the urgent need for an advanced technology to target tumor cells. Nanotechnology has emerged as one such revolutionary platform to specifically target cancerous tissues and to enhance the efficacy for various anticancer drugs. This report is a snapshot of the patents in chemotherapy from January 2010 to May 2020 involving nanoparticles, novel methods developed for their synthesis and their impact as efficient drug-delivery vehicles.

Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs

2009 ◽  
Vol 103 (3) ◽  
pp. 373-380 ◽  
Author(s):  
Michelle J. Pisani ◽  
Nial J. Wheate ◽  
F. Richard Keene ◽  
Janice R. Aldrich-Wright ◽  
J. Grant Collins
Keyword(s):  
Drug Delivery ◽  
Transition Metal ◽  
Anticancer Drugs ◽  
Pamam Dendrimers ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

The role of amino acid functionalization for improvement of adsorption Thioguanine anticancer drugs on the boron nitride nanotubes for drug delivery

2021 ◽  
pp. 125664
Author(s):  
Yasir A. Atia ◽  
Dmitry Olegovich Bokov ◽  
Khayrullin Rustam Zinnatullovich ◽  
Mustafa M. Kadhim ◽  
Wanich Suksatan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Boron Nitride ◽  
Anticancer Drugs ◽  
Boron Nitride Nanotubes

scholarly journals Hollow silica capsules for amphiphilic transport and sustained delivery of antibiotic and anticancer drugs

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 24883-24892 ◽  
Author(s):  
Isabel Gessner ◽  
Eva Krakor ◽  
Anna Jurewicz ◽  
Veronika Wulff ◽  
Lasse Kling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Sustained Release ◽  
Anticancer Drugs ◽  
Sustained Delivery ◽  
Hollow Silica ◽  
Drug Delivery Vehicles ◽  
Amphiphilic Drug ◽  
Delivery Vehicles ◽  
Hollow Mesoporous Silica

Hollow mesoporous silica capsules were used as amphiphilic drug delivery vehicles and sustained release systems for antimicrobial and anticancer drugs.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects
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