Control of voluntary and reflexive saccades

2000 ◽  
Vol 130 (4) ◽  
pp. 540-544 ◽  
Author(s):  
Robin Walker ◽  
David G. Walker ◽  
Masud Husain ◽  
Christopher Kennard
Keyword(s):  
Reflexive Saccades

Endogenously Generated and Visually Guided Saccades after Lesions of the Human Frontal Eye Fields

1994 ◽  
Vol 6 (4) ◽  
pp. 400-411 ◽  
Author(s):  
Avishai Henik ◽  
Robert Rafal ◽  
Dell Rhodes
Keyword(s):  
Prefrontal Cortex ◽  
Visual Display ◽  
Covert Attention ◽  
Visual Signal ◽  
Frontal Eye Fields ◽  
Opposite Pattern ◽  
Control Subjects ◽  
Key Press ◽  
Reflexive Saccades ◽  
Voluntary Saccades

Nine patients with chronic, unilateral lesions of the dorso-lateral prefrontal cortex including the frontal eye fields (FEF) made saccades toward contralesional and ipsilesional fields. The saccades were either voluntarily directed in response to arrows in the center of a visual display, or were reflexively summoned by a peripheral visual signal. Saccade latencies were compared to those made by seven neurologic control patients with chronic, unilateral lesions of dorsolateral prefrontal cortex sparing the FEF, and by 13 normal control subjects. In both the normal and neurologic control subjects, reflexive saccades had shorter Latencies than voluntary saccades. In the FEF lesion patients, voluntary saccades had longer latencies toward the contralesional field than toward the ipsilesional field. The opposite pattern was found for reflexive saccades: latencies of saccades to targets in the contralesional field were shorter than saccades summoned to ipsilesional targets. Reflexive saccades toward the ipsilesional field had abnormally prolonged latencies; they were comparable to the latencies observed for voluntary Saccades. The effect of FEF lesions on saccacles contrasted with those observed in a second experiment requiring a key press response: FEF lesion patients were slower in making key press responses to signals detected in the contralesional field. To assess covert attention and preparatory set the effects of precues providing advance information were measured in both saccade and key press experiments. Neither patient group showed any deficiency in using precues to shift attention or to prepare saccades. The FEF facilitates the generation of voluntary saccatles and also inhibits reflexive saccades to exogenous signals. FEF lesions may disinhibit the ipsilesional midbrain which in turn may inhibit the opposite colliculus to slow reflexive saccades toward the ipsilesional field.

Disturbances in the Control of Saccadic Eye Movement and Eye-Head Coordination in Schizophrenics1

1991 ◽  
Vol 1 (2) ◽  
pp. 171-180
Author(s):  
Junko Fukushima ◽  
Kikuro Fukushima ◽  
Nobuyuki Morita ◽  
Itaru Yamashita
Keyword(s):  
Frontal Cortex ◽  
Head Movement ◽  
Head Movements ◽  
Saccadic Eye Movement ◽  
Antisaccade Task ◽  
Schizophrenic Patients ◽  
Saccade Task ◽  
Cortical Dysfunction ◽  
Reflexive Saccades ◽  
Target Memory

Some schizophrenic patients have been known to have frontal cortical dysfunction. In view of the evidence that voluntary purposive eye movements and rapid head movements involve areas of the frontal cortex, investigations of saccade performance have been carried out on schizophrenics in various laboratories. We have compared performance of schizophrenic patients in tasks involving inhibition of reflexive saccades (no-saccade) and initiation of saccades without target (memory-saccade) with performance in. the antisaccade task. These measures were also compared with results of eye-head coordination tasks. Schizophrenics showed more errors and significantly longer latencies, with lower peak velocities at large amplitudes, in both the anti saccade task and the memory-saccade task. Performance with coordinated eye-head movement was basically similar, except for significantly longer latencies of head movement. These results suggest that schizophrenics may have a disturbance in initiating and executing purposive saccades without targets, and that dysfunction of the frontal cortex may contribute to this disturbance.

scholarly journals Working Memory and the Suppression of Reflexive Saccades

2002 ◽  
Vol 14 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Jason P. Mitchell ◽  
C. Neil Macrae ◽  
Iain D. Gilchrist
Keyword(s):  
Working Memory ◽  
Memory Load ◽  
Critical Role ◽  
Memory Task ◽  
Behavioral Responses ◽  
Error Rates ◽  
Antisaccade Task ◽  
Working Memory Load ◽  
Reflexive Saccades ◽  
Back Task

Conscious behavioral intentions can frequently fail under conditions of attentional depletion. In attempting to trace the cognitive origin of this effect, we hypothesized that failures of action control—specifically, oculomotor movement—can result from the imposition of fronto-executive load. To evaluate this prediction, participants performed an antisaccade task while simultaneously completing a working-memory task that is known to make variable demands on prefrontal processes (n-back task, see Jonides et al., 1997). The results of two experiments are reported. As expected, antisaccade error rates were increased in accordance with the fronto-executive demands of the n-back task (Experiment 1). In addition, the debilitating effects of working-memory load were restricted to the inhibitory component of the antisaccade task (Experiment 2). These findings corroborate the view that working memory operations play a critical role in the suppression of prepotent behavioral responses.

Higher level influences on saccade generation in normals and patients with visual hemineglect

1999 ◽  
Vol 22 (4) ◽  
pp. 688-689
Author(s):  
Wolfgang Heide ◽  
Andreas Sprenger ◽  
Detlef Kömpf
Keyword(s):  
Human Subjects ◽  
Perceptual Processing ◽  
Visual Exploration ◽  
Frontal Eye Field ◽  
Automatic Processes ◽  
Eye Field ◽  
Level 3 ◽  
Normal Human ◽  
Reflexive Saccades ◽  
Saccade Generation

In this commentary we describe findings in normal human subjects and in patients with visual hemineglect that support the importance of higher-level influences on saccade generation during visual exploration. As the duration of fixations increases with increases in the cognitive demand of the task, the timing of exploratory saccades is controlled more by centers of cognitive and perceptual processing at levels 4 and 5 than by reflex-like automatic processes at level 3. In line with this, unilateral frontal eye field lesions impair systematic, intentional saccadic exploration of visual scenes, causing prolonged fixations and contralesional hemineglect, but leave visually triggered reflexive saccades largely intact.

scholarly journals Voluntary Spatial Attention has Different Effects on Voluntary and Reflexive Saccades

2003 ◽  
Vol 3 ◽  
pp. 881-902 ◽  
Author(s):  
Stephanie K. Seidlits ◽  
Tammie Reza ◽  
Kevin A. Briand ◽  
Anne B. Sereno
Keyword(s):  
Eye Movements ◽  
Spatial Attention ◽  
Saccadic Eye Movements ◽  
Fundamental Issue ◽  
Fixation Condition ◽  
The Subject ◽  
Symbolic Cues ◽  
The Relationship ◽  
Reflexive Saccades ◽  
Gap Paradigm

Although numerous studies have investigated the relationship between saccadic eye movements and spatial attention, one fundamental issue remains controversial. Some studies have suggested that spatial attention facilitates saccades, whereas others have claimed that eye movements are actually inhibited when spatial attention is engaged. However, these discrepancies may be because previous research has neglected to separate and specify the effects of attention for two distinct types of saccades, namely reflexive (stimulus-directed) and voluntary (antisaccades). The present study explored the effects of voluntary spatial attention on both voluntary and reflexive saccades. Results indicate that voluntary spatial attention has different effects on the two types of saccades. Antisaccades were always greatly facilitated following the engagement of spatial attention by symbolic cues (arrows) informing the subject where the upcoming saccade should be directed. Reflexive saccades showed little or no cueing effects and exhibited significant facilitation only when these cues were randomly intermixed with uncued trials. In addition, the present study tested the effects of fixation condition (gap, step, and overlap) on attentional modulation. Cueing effects did not vary due to fixation condition. Thus, voluntary spatial attention consistently showed different effects on voluntary and reflexive saccades, and there was no evidence in these studies that voluntary cues inhibit reflexive saccades, even in a gap paradigm.

Differential cortical activation during voluntary and reflexive saccades in man

NeuroImage ◽  
2003 ◽  
Vol 18 (2) ◽  
pp. 231-246 ◽  
Author(s):  
Dominic J Mort ◽  
Richard J Perry ◽  
Sabira K Mannan ◽  
Timothy L Hodgson ◽  
Elaine Anderson ◽  
...  
Keyword(s):  
Cortical Activation ◽  
Reflexive Saccades

Impairment of voluntary saccades and facilitation of reflexive saccades do not co-occur in Parkinson’s disease

2012 ◽  
Vol 19 (8) ◽  
pp. 1119-1124 ◽  
Author(s):  
Saskia van Stockum ◽  
Michael R. MacAskill ◽  
Tim J. Anderson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reflexive Saccades ◽  
Voluntary Saccades

scholarly journals Inhibition failures and late errors in the antisaccade task: influence of cue delay

2018 ◽  
Vol 120 (6) ◽  
pp. 3001-3016 ◽  
Author(s):  
Eduardo A. Aponte ◽  
Dominic G. Tschan ◽  
Klaas E. Stephan ◽  
Jakob Heinzle
Keyword(s):  
Quantitative Analysis ◽  
Contextual Effects ◽  
Summary Statistics ◽  
Antisaccade Task ◽  
Voluntary Response ◽  
Early Reaction ◽  
Underlying Processes ◽  
Reflexive Saccades ◽  
Reaction Inhibition ◽  
Types Of Error

In the antisaccade task participants are required to saccade in the opposite direction of a peripheral visual cue (PVC). This paradigm is often used to investigate inhibition of reflexive responses as well as voluntary response generation. However, it is not clear to what extent different versions of this task probe the same underlying processes. Here, we explored with the Stochastic Early Reaction, Inhibition, and late Action (SERIA) model how the delay between task cue and PVC affects reaction time (RT) and error rate (ER) when pro- and antisaccade trials are randomly interleaved. Specifically, we contrasted a condition in which the task cue was presented before the PVC with a condition in which the PVC served also as task cue. Summary statistics indicate that ERs and RTs are reduced and contextual effects largely removed when the task is signaled before the PVC appears. The SERIA model accounts for RT and ER in both conditions and better so than other candidate models. Modeling demonstrates that voluntary pro- and antisaccades are frequent in both conditions. Moreover, early task cue presentation results in better control of reflexive saccades, leading to fewer fast antisaccade errors and more rapid correct prosaccades. Finally, high-latency errors are shown to be prevalent in both conditions. In summary, SERIA provides an explanation for the differences in the delayed and nondelayed antisaccade task.NEW & NOTEWORTHY In this article, we use a computational model to study the mixed antisaccade task. We contrast two conditions in which the task cue is presented either before or concurrently with the saccadic target. Modeling provides a highly accurate account of participants’ behavior and demonstrates that a significant number of prosaccades are voluntary actions. Moreover, we provide a detailed quantitative analysis of the types of error that occur in pro- and antisaccade trials.

scholarly journals Suppression of reflexive saccades in younger and older adults: Age comparisons on an antisaccade task

1999 ◽  
Vol 27 (4) ◽  
pp. 584-591 ◽  
Author(s):  
Karin M. Butler ◽  
Rose T. Zacks ◽  
John M. Henderson
Keyword(s):  
Older Adults ◽  
Antisaccade Task ◽  
Reflexive Saccades
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