Docosahexaenoic acid supplementation in age-related cognitive decline: a systematic review and meta-analysis

2020 ◽  
Vol 76 (5) ◽  
pp. 639-648 ◽  
Author(s):  
Rakesh Balachandar ◽  
Soundarya Soundararajan ◽  
Bhavani Shankara Bagepally
Keyword(s):  
Systematic Review ◽  
Docosahexaenoic Acid ◽  
Cognitive Decline ◽  
Meta Analysis ◽  
Acid Supplementation ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults

2021 ◽  
Vol Volume 17 ◽  
pp. 971-990
Author(s):  
Aprinda Indahlastari ◽  
Cheshire Hardcastle ◽  
Alejandro Albizu ◽  
Stacey Alvarez-Alvarado ◽  
Emanuel M Boutzoukas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cognitive Decline ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Meta Analysis ◽  
Healthy Older Adults ◽  
Direct Current Stimulation ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals The Interest of Adding Micronutrients to Docosahexaenoic Acid Supplementation to Prevent Age-Related Cognitive Decline

2018 ◽  
Vol 08 (03) ◽  
Author(s):  
Mathilde Chataigner ◽  
Anne-Laure Dinel ◽  
Veronique Pallet ◽  
Sophie Laye ◽  
Corinne Joffre
Keyword(s):  
Docosahexaenoic Acid ◽  
Cognitive Decline ◽  
Acid Supplementation ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

2021 ◽  
Vol 67 ◽  
pp. 101302
Author(s):  
Benjamin Kioussis ◽  
Camilla S.L. Tuttle ◽  
Daniel S. Heard ◽  
Brian K. Kennedy ◽  
Nicola T. Lautenschlager ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Decline ◽  
Nutrient Sensing ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 78 (3) ◽  
pp. 1047-1088
Author(s):  
Nena Lejko ◽  
Daouia I. Larabi ◽  
Christoph S. Herrmann ◽  
André Aleman ◽  
Branislava Ćurčić-Blake
Keyword(s):  
Functional Connectivity ◽  
Cognitive Decline ◽  
Meta Analysis ◽  
Neural Oscillations ◽  
Alpha Power ◽  
Healthy Older Adults ◽  
Age Related ◽  
Neurodegenerative Dementia ◽  
Meta Analyses ◽  
Age Related Cognitive Decline

Background: Mild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia. Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range. Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though several studies measured alpha power and synchronization in MCI, findings have not yet been integrated. Objective: To consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline. Methods: We included studies published until January 2020 that compared power or functional connectivity between 1) people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people with progressive and stable MCI. Random-effects meta-analyses were performed when enough data was available. Results: Sixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = –0.30; 95% CI = –0.51, –0.10; k = 6), and in MCI than in OA (ES = –1.49; 95% CI = –2.69, –0.29; k = 5). However, the latter meta-analysis should be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressive than in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higher functional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures. Conclusion: Research indicates that RS alpha power decreases with increasing impairment, and could—combined with measures from other frequency bands—become a biomarker of early cognitive decline.

New insights into docosahexaenoic acid homeostasis during age-;related cognitive decline

2014 ◽  
Vol 26 (4) ◽  
pp. 79-81
Author(s):  
Marie Hennebelle ◽  
Christian-Alexandre Castellano ◽  
Mélanie Plourde
Keyword(s):  
Docosahexaenoic Acid ◽  
Cognitive Decline ◽  
Age Related ◽  
Age Related Cognitive Decline
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