scholarly journals Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 78 (3) ◽  
pp. 1047-1088
Author(s):  
Nena Lejko ◽  
Daouia I. Larabi ◽  
Christoph S. Herrmann ◽  
André Aleman ◽  
Branislava Ćurčić-Blake
Keyword(s):  
Functional Connectivity ◽  
Cognitive Decline ◽  
Meta Analysis ◽  
Neural Oscillations ◽  
Alpha Power ◽  
Healthy Older Adults ◽  
Age Related ◽  
Neurodegenerative Dementia ◽  
Meta Analyses ◽  
Age Related Cognitive Decline

Background: Mild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia. Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range. Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though several studies measured alpha power and synchronization in MCI, findings have not yet been integrated. Objective: To consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline. Methods: We included studies published until January 2020 that compared power or functional connectivity between 1) people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people with progressive and stable MCI. Random-effects meta-analyses were performed when enough data was available. Results: Sixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = –0.30; 95% CI = –0.51, –0.10; k = 6), and in MCI than in OA (ES = –1.49; 95% CI = –2.69, –0.29; k = 5). However, the latter meta-analysis should be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressive than in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higher functional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures. Conclusion: Research indicates that RS alpha power decreases with increasing impairment, and could—combined with measures from other frequency bands—become a biomarker of early cognitive decline.

scholarly journals The Effects of the BAILAMOS Dance Program on Brain Functional Connectivity of Older Latinos: An Exploratory Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 504-505
Author(s):  
Guilherme Moraes Balbim ◽  
Olusola Ajilore ◽  
Melissa Lamar ◽  
Kirk Erickson ◽  
Susan Aguiñaga ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Decline ◽  
Resting State ◽  
Leisure Time Physical Activity ◽  
Brain Networks ◽  
Resting State Fmri ◽  
Post Intervention ◽  
Age Related ◽  
Brain Functional Connectivity ◽  
Age Related Cognitive Decline

Abstract Compared to non-Latinos whites, older Latinos are at higher risk of cognitive impairment and engage in less leisure-time physical activity (PA). Resting-state brain functional connectivity (FC) is a putative biomarker for age-related cognitive decline. PA plays a role in FC of brain networks associated with cognitive decline. Objective: Investigate the effects of the BAILAMOS™ dance program on FC in three brain networks associated with age-related cognitive decline (Default Mode [DMN], Frontoparietal [FPN], and Salience [SAL] networks). Methods: Single-group pre-post design. Ten cognitively intact older Latinos participated in the four-month (2x/week for 60min) BAILAMOS™ dance program with four Latin dance styles. MRI was obtained pre- and post-intervention. FC was analyzed using the resting-state fMRI toolbox (CONN) via pairwise BOLD signal correlations and then converted into z-scores. We performed dependent t-tests, computed Cohen’s d and 95%CI for p < 0.05. Results: Within-FPN FC significantly increased (t(9) = 2.35, p = 0.043, d = 0.70) from pre (M=0.49±0.15) to post-intervention (M=0.59±0.13). In the DMN, we observed moderate effect size changes in the ratio of the FC between-networks by the FC within-networks (Mdiff = 0.10; 95%CI = -0.01; 0.21, p = 0.08, d = 0.64). Conclusions: The BAILAMOS™ program increased within-FPN FC, which is a cognitive-control network related to adaptive control and flexibility. Moderate changes between- vs. within-DMN FC suggest BAILAMOS™ also increased whole-brain DMN integration. Taken together, results might signal that Latin dance can combat the disruption of FC between the DMN and other networks, and within-FPN, which are associated with cognitive decline.

scholarly journals Functional Requirements of Small- and Large-Scale Neural Circuitry Connectome Models

2020 ◽  
pp. 249-260
Author(s):  
Kristen W. Carlson ◽  
Jay L. Shils ◽  
Longzhi Mei ◽  
Jeffrey E. Arle
Keyword(s):  
Back Pain ◽  
Functional Connectivity ◽  
Cognitive Decline ◽  
Large Scale ◽  
Neural Circuitry ◽  
Functional Requirements ◽  
Computational Power ◽  
Age Related ◽  
The Subject ◽  
Age Related Cognitive Decline

AbstractWe have truly entered the Age of the Connectome due to a confluence of advanced imaging tools, methods such as the flavors of functional connectivity analysis and inter-species connectivity comparisons, and computational power to simulate neural circuitry. The interest in connectomes is reflected in the exponentially rising number of articles on the subject. What are our goals? What are the “functional requirements” of connectome modelers? We give a perspective on these questions from our group whose focus is modeling neurological disorders, such as neuropathic back pain, epilepsy, Parkinson’s disease, and age-related cognitive decline, and treating them with neuromodulation.

Genome‐wide meta‐analysis of age‐related cognitive decline in population‐based older individuals

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Vibha Acharya ◽  
Kang‐Hsien Fan ◽  
Beth E Snitz ◽  
Mary Ganguli ◽  
Steve DeKosky ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Meta Analysis ◽  
Population Based ◽  
Older Individuals ◽  
Age Related ◽  
Genome Wide ◽  
Age Related Cognitive Decline

Activity Engagement in Cognitive Aging: A Review of the Evidence

2013 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Social Activity ◽  
Current Evidence ◽  
Omega 3 ◽  
Neuroprotective Effects ◽  
Activity Engagement ◽  
Age Related ◽  
Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

Sign in / Sign up

Export Citation Format

Share Document