Different FreeSurfer versions might generate different statistical outcomes in case–control comparison studies

AbstractBreast cancer is the most prevalent cancer in women. Early detection of this disease improves survival and therefore population screenings, based on mammography, are performed. However, the sensitivity of this screening modality is not optimal and new screening methods, such as blood tests, are being explored. Most of the analyses that aim for early detection focus on proteins in the bloodstream. In this study, the biomarker potential of total serum N-glycosylation analysis was explored with regard to detection of breast cancer. In an age-matched case-control setup serum protein N-glycan profiles from 145 breast cancer patients were compared to those from 171 healthy individuals. N-glycans were enzymatically released, chemically derivatized to preserve linkage-specificity of sialic acids and characterized by high resolution mass spectrometry. Logistic regression analysis was used to evaluate associations of specific N-glycan structures as well as N-glycosylation traits with breast cancer. In a case-control comparison three associations were found, namely a lower level of a two triantennary glycans and a higher level of one tetraantennary glycan in cancer patients. Of note, various other N-glycomic signatures that had previously been reported were not replicated in the current cohort. It was further evaluated whether the lack of replication of breast cancer N-glycomic signatures could be partly explained by the heterogenous character of the disease since the studies performed so far were based on cohorts that included diverging subtypes in different numbers. It was found that serum N-glycan profiles differed for the various cancer subtypes that were analyzed in this study.

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Study of the incidence of hypospadias in Rochester, Minnesota 1940–1970, and a case control comparison of possible etiologic factors

Plastic & Reconstructive Surgery ◽

10.1097/00006534-197407001-00055 ◽

1974 ◽

Vol 54 ◽

pp. 238

Author(s):

Jack C. Fisher

Keyword(s):

Case Control ◽

Control Comparison

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Association between adult attention-deficit hyperactivity disorder and generalised joint hypermobility: A cross-sectional case control comparison

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2021.07.006 ◽

2021 ◽

Author(s):

Martin Glans ◽

Nils Thelin ◽

Mats B. Humble ◽

Marie Elwin ◽

Susanne Bejerot

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Attention Deficit ◽

Case Control ◽

Joint Hypermobility ◽

Cross Sectional ◽

Hyperactivity Disorder ◽

Control Comparison

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A case-control comparison of durability and cost between implanted reservoir and percutaneous catheters in cancer patients

Journal of Surgical Research ◽

10.1016/0022-4804(91)90137-b ◽

1991 ◽

Vol 51 (5) ◽

pp. 377-381 ◽

Cited By ~ 14

Author(s):

David McCready ◽

Ralph Broadwater ◽

Merrick Ross ◽

Raphael Pollock ◽

David Ota ◽

...

Keyword(s):

Cancer Patients ◽

Case Control ◽

Control Comparison

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PSY49 PATIENT-REPORTED OUTCOMES, HEALTH CARE RESOURCES UTILIZATION, WORK PRODUCTIVITY AND THEIR ASSOCIATED COSTS IN PATIENTS WITH NEUROPATHIC PAIN: A CASE CONTROL COMPARISON OF TREATMENT WITH PREGABALIN VERSUS GABAPENTIN IN ROUTINE MEDICAL PRACTICE

Value in Health ◽

10.1016/s1098-3015(10)67099-4 ◽

2008 ◽

Vol 11 (6) ◽

pp. A644-A645

Author(s):

C Pérez ◽

A Navarro ◽

MT Saldaña ◽

X Masramón ◽

J Rejas

Keyword(s):

Health Care ◽

Neuropathic Pain ◽

Medical Practice ◽

Patient Reported Outcomes ◽

Work Productivity ◽

Case Control ◽

Health Care Resources ◽

Patient Reported ◽

Control Comparison ◽

Routine Medical Practice

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Dietary patterns and CVD: a systematic review and meta-analysis of observational studies

British Journal Of Nutrition ◽

10.1017/s0007114515003177 ◽

2015 ◽

Vol 114 (9) ◽

pp. 1341-1359 ◽

Cited By ~ 75

Author(s):

Míriam Rodríguez-Monforte ◽

Gemma Flores-Mateo ◽

Emília Sánchez

Keyword(s):

Cohort Studies ◽

Dietary Patterns ◽

Observational Studies ◽

Protective Factor ◽

Meta Analysis ◽

Epidemiological Studies ◽

Case Control ◽

Case Control Studies ◽

Chd Risk ◽

Control Comparison

AbstractEpidemiological studies show that diet is linked to the risk of developing CVD. The objective of this meta-analysis was to estimate the association between empirically derived dietary patterns and CVD. PubMed was searched for observational studies of data-driven dietary patterns that reported outcomes of cardiovascular events. The association between dietary patterns and CVD was estimated using a random-effects meta-analysis with 95 % CI. Totally, twenty-two observational studies met the inclusion criteria. The pooled relative risk (RR) for CVD, CHD and stroke in a comparison of the highest to the lowest category of prudent/healthy dietary patterns in cohort studies was 0·69 (95 % CI 0·60, 0·78; I2=0 %), 0·83 (95 % CI 0·75, 0·92; I2=44·6 %) and 0·86 (95 % CI 0·74, 1·01; I2=59·5 %), respectively. The pooled RR of CHD in a case–control comparison of the highest to the lowest category of prudent/healthy dietary patterns was 0·71 (95 % CI 0·63, 0·80; I2=0 %). The pooled RR for CVD, CHD and stroke in a comparison of the highest to the lowest category of western dietary patterns in cohort studies was 1·14 (95 % CI 0·92, 1·42; I2=56·9 %), 1·03 (95 % CI 0·90, 1·17; I2=59·4 %) and 1·05 (95 % CI 0·91, 1·22; I2=27·6 %), respectively; in case–control studies, there was evidence of increased CHD risk. Our results support the evidence of the prudent/healthy pattern as a protective factor for CVD.

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