Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

AbstractThe ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.

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Phone-Based Restaurant Recommendation System by Using Position Information and Association Rules

Advanced Engineering Forum ◽

10.4028/www.scientific.net/aef.6-7.783 ◽

2012 ◽

Vol 6-7 ◽

pp. 783-789

Author(s):

Jian Feng Dong ◽

Tian Yang Dong ◽

Jia Jie Yao ◽

Ling Zhang

Keyword(s):

Mobile Phone ◽

Real Time ◽

Association Rules ◽

Recommendation System ◽

Rapid Development ◽

Smart Phone ◽

Smart Phones ◽

Location Information ◽

Position Information ◽

The Real

With the rapid development of smart-phone applications, how to make the ordering process via smart-phones more convenient and intelligent has become a hotspot. This paper puts forward a method of restaurant dish recommendation relying on position information and association rules. In addition, this paper has designed and developed a restaurant recommendation system based on mobile phone. The system would fetch the real-time location information via smart-phones, and provide customers personalized restaurant and dish recommendation service. According to the related applications, this system can successfully recommend the related restaurants and food information to customers.

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Symposium Title: Training the Brain–Methodological Progress and Clinical Translation of Real-Time Neurofeedback Closed-Loop Modulation

International Journal of Psychophysiology ◽

10.1016/j.ijpsycho.2021.07.250 ◽

2021 ◽

Vol 168 ◽

pp. S81

Author(s):

Benjamin Becker

Keyword(s):

Real Time ◽

Closed Loop ◽

Clinical Translation ◽

The Brain

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A Comprehensive Survey on Cyber-Physical Smart Grid Testbed Architectures: Requirements and Challenges

Electronics ◽

10.3390/electronics10091043 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1043

Author(s):

Abdallah A. Smadi ◽

Babatunde Tobi Ajao ◽

Brian K. Johnson ◽

Hangtian Lei ◽

Yacine Chakhchoukh ◽

...

Keyword(s):

Smart Grid ◽

Real Time ◽

Smart Grids ◽

Data Exchange ◽

Information Technologies ◽

New Technologies ◽

Rapid Development ◽

Environmental Benefits ◽

Future Research ◽

Time Data

The integration of improved control techniques with advanced information technologies enables the rapid development of smart grids. The necessity of having an efficient, reliable, and flexible communication infrastructure is achieved by enabling real-time data exchange between numerous intelligent and traditional electrical grid elements. The performance and efficiency of the power grid are enhanced with the incorporation of communication networks, intelligent automation, advanced sensors, and information technologies. Although smart grid technologies bring about valuable economic, social, and environmental benefits, testing the combination of heterogeneous and co-existing Cyber-Physical-Smart Grids (CP-SGs) with conventional technologies presents many challenges. The examination for both hardware and software components of the Smart Grid (SG) system is essential prior to the deployment in real-time systems. This can take place by developing a prototype to mimic the real operational circumstances with adequate configurations and precision. Therefore, it is essential to summarize state-of-the-art technologies of industrial control system testbeds and evaluate new technologies and vulnerabilities with the motivation of stimulating discoveries and designs. In this paper, a comprehensive review of the advancement of CP-SGs with their corresponding testbeds including diverse testing paradigms has been performed. In particular, we broadly discuss CP-SG testbed architectures along with the associated functions and main vulnerabilities. The testbed requirements, constraints, and applications are also discussed. Finally, the trends and future research directions are highlighted and specified.

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Comparison of Leading Biosensor Technologies to Detect Changes in Human Endothelial Barrier Properties in Response to Pro-Inflammatory TNFα and IL1β in Real-Time

Biosensors ◽

10.3390/bios11050159 ◽

2021 ◽

Vol 11 (5) ◽

pp. 159

Author(s):

James J. W. Hucklesby ◽

Akshata Anchan ◽

Simon J. O'Carroll ◽

Charles P. Unsworth ◽

E. Scott Graham ◽

...

Keyword(s):

Human Brain ◽

Real Time ◽

Barrier Properties ◽

Endothelial Barrier ◽

Endothelial Monolayer ◽

Impedance Sensing ◽

Endothelial Monolayers ◽

Impedance Data ◽

Cell Substrate ◽

Limited Frequency

Electric Cell-Substrate Impedance Sensing (ECIS), xCELLigence and cellZscope are commercially available instruments that measure the impedance of cellular monolayers. Despite widespread use of these systems individually, direct comparisons between these platforms have not been published. To compare these instruments, the responses of human brain endothelial monolayers to TNFα and IL1β were measured on all three platforms simultaneously. All instruments detected transient changes in impedance in response to the cytokines, although the response magnitude varied, with ECIS being the most sensitive. ECIS and cellZscope were also able to attribute responses to particular endothelial barrier components by modelling the multifrequency impedance data acquired by these instruments; in contrast the limited frequency xCELLigence data cannot be modelled. Consistent with its superior impedance sensing, ECIS exhibited a greater capacity than cellZscope to distinguish between subtle changes in modelled endothelial monolayer properties. The reduced resolving ability of the cellZscope platform may be due to its electrode configuration, which is necessary to allow access to the basolateral compartment, an important advantage of this instrument. Collectively, this work demonstrates that instruments must be carefully selected to ensure they are appropriate for the experimental questions being asked when assessing endothelial barrier properties.

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