Potential role of endothelin-1 and endothelin antagonists in cardiovascular diseases

2000 ◽  
Vol 95 (4) ◽  
pp. 290-298 ◽  
Author(s):  
Simone Schmitz-Spanke ◽  
J. D. Schipke
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role ◽  
Endothelin 1 ◽  
Endothelin Antagonists

scholarly journals The Role of Uridine Adenosine Tetraphosphate in the Vascular System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Rita C. Tostes ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Smooth Muscle Cells ◽  
Vascular Function ◽  
Purinergic Receptors ◽  
Potential Role ◽  
Vascular System

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

scholarly journals The potential role of miRNAs in calcification of cardiovascular diseases

2019 ◽  
pp. 118-125 ◽  
Author(s):  
A. G. Ibragimova ◽  
K. R. Shakhmaeva ◽  
I. E. Stanishevskaya ◽  
A. V. Shindyapina
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role

scholarly journals MicroRNA-143/-145 in Cardiovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Zhao ◽  
Shui-Ping Zhao ◽  
Yu-Hong Zhao
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle Cells ◽  
Essential Role ◽  
Recent Progress ◽  
Potential Role ◽  
Phenotypic Switching ◽  
Diagnostic Biomarkers ◽  
Potential Strategy

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

Potential Role of Endothelin-1 in Pulmonary Fibrosis: From the Bench to the Clinic

2010 ◽  
Vol 42 (5) ◽  
pp. 633-633 ◽  
Author(s):  
Nicole P. Barlo ◽  
Coline H. M. van Moorsel ◽  
Karin M. Kazemier ◽  
Jules M. M. van den Bosch ◽  
Jan C. Grutters
Keyword(s):  
Pulmonary Fibrosis ◽  
Potential Role ◽  
Endothelin 1

Potential Role of Endothelin-1 in Pulmonary Fibrosis

2010 ◽  
Vol 42 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Bryan Ross ◽  
Pedro D'Orléans-Juste ◽  
Adel Giaid
Keyword(s):  
Pulmonary Fibrosis ◽  
Potential Role ◽  
Endothelin 1
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