scholarly journals The potential role of miRNAs in calcification of cardiovascular diseases

2019 ◽  
pp. 118-125 ◽  
Author(s):  
A. G. Ibragimova ◽  
K. R. Shakhmaeva ◽  
I. E. Stanishevskaya ◽  
A. V. Shindyapina
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role

scholarly journals The Role of Uridine Adenosine Tetraphosphate in the Vascular System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Rita C. Tostes ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Smooth Muscle Cells ◽  
Vascular Function ◽  
Purinergic Receptors ◽  
Potential Role ◽  
Vascular System

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

scholarly journals MicroRNA-143/-145 in Cardiovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Zhao ◽  
Shui-Ping Zhao ◽  
Yu-Hong Zhao
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle Cells ◽  
Essential Role ◽  
Recent Progress ◽  
Potential Role ◽  
Phenotypic Switching ◽  
Diagnostic Biomarkers ◽  
Potential Strategy

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

scholarly journals IL-37—a putative therapeutic agent in cardiovascular diseases

QJM ◽  
2021 ◽  
Author(s):  
S McCurdy ◽  
J Yap ◽  
J Irei ◽  
J Lozano ◽  
W A Boisvert
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Orphan Receptor ◽  
Elevated Plasma ◽  
Coronary Syndrome

Summary Although it is a member of the Interleukin (IL)-1 family, IL-37 is unique in that it has wide-ranging anti-inflammatory characteristics. It was originally thought to prevent IL-18-mediated inflammation by binding to the IL-18-binding protein. However, upon discovery that it binds to the orphan receptor, IL-1R8, further studies have revealed an expanded role of IL-37 to include several intracellular and extracellular pathways that affect various aspects of inflammation. Its potential role specifically in cardiovascular diseases (CVD) stemmed initially from the discovery of elevated plasma IL-37 levels in human patients with acute coronary syndrome and atrial fibrillation. Other studies using mouse models of ischemia/reperfusion injury, vascular calcification and myocardial infarction have revealed that IL-37 can have a beneficial role in these conditions. This review will explore recent research on the effects of IL-37 on the pathogenesis of CVD.

The potential role of antioxidant vitamins in preventing cardiovascular diseases and cancers

Nutrition ◽  
1998 ◽  
Vol 14 (6) ◽  
pp. 513-520 ◽  
Author(s):  
Serge Hercberg ◽  
Pilar Galan ◽  
Paul Preziosi ◽  
Maria-Jose Alfarez ◽  
Clotilde Vazquez
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role ◽  
Antioxidant Vitamins

scholarly journals POTENTIAL ROLE OF GUT MICROBIOTA IN OBESITY AND CARDIOVASCULAR DISEASES

2021 ◽  
Vol 54 (3) ◽  
pp. 207-213
Author(s):  
Sana Ashiq ◽  
Kanwal Ashiq
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Homeostasis ◽  
Mortality And Morbidity ◽  
The Past ◽  
Dietary Components ◽  
Insight Into

From the past several decades to the present, obesity and cardiovascular diseases emerge as a major cause of mortality and morbidity, ultimately imposing a huge economic burden globally. In humans, a healthy gut microbiota metabolizes several indigestible dietary components which maintain host immune homeostasis, but an imbalanced host-microbiota is associated with various metabolic disorders including cardiovascular diseases and obesity. In this present review, we critically analyze the literature which provides better insight into the mechanistic link of gut microbiota with obesity and cardiovascular diseases. There is strong evidence that suggests the potential role of the gut microbiota in metabolic disorders including cardiovascular diseases and obesity. In addition, the different studies report that gut microbes can play a promising role in the management of obesity and the treatment of cardiovascular diseases. In the future, multidisciplinary approaches and advancements in culturing and molecular biology techniques can provide us a better understanding.

scholarly journals The role of microRNA in the diagnosis of cardiovascular diseases in obese patients

2021 ◽  
Vol 23 (4) ◽  
pp. 358-362
Author(s):  
Teona A. Shvangiradze ◽  
◽  
Irina Z. Bondarenko ◽  
Ekaterina A. Troshina ◽  
◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Potential Role ◽  
Modern Society ◽  
Initial Step ◽  
Obese Patients ◽  
Altered Expression ◽  
Global Problem ◽  
Increased Risk

Obesity remains a global problem in modern society. It is commonly associated with an increased risk of cardiovascular diseases (CVD). The search for specific and sensitive biomarkers of CVD continues. Currently, a lot of studies focused on the potential role of microRNA (miRNA) in CVD development and progression. MiRNAs are involved in various pathological disorders associated with CVD. Endothelial dysfunction is considered as the initial step in the pathogenesis of many CVD, and atherosclerosis in particular. Altered expression of several miRNAs is associated with the development of endothelial dysfunction. Some miRNAs are considered as potential therapeutic targets. Further studies to evaluate the role of miRNAs in the pathogenesis of CVD are needed. It will improve the diagnosis and treatment of CVD in patients with obesity.

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