scholarly journals Circular RNA profiling distinguishes medullobastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma

2021 ◽  
Author(s):  
Daniel Rickert ◽  
Jasmin Bartl ◽  
Daniel Picard ◽  
Flavia Bernardi ◽  
Nan Qin ◽  
...  
Keyword(s):  
Circular Rna ◽  
Rna Profiling

scholarly journals Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer

2019 ◽  
Vol 11 (5) ◽  
pp. 1779-1787 ◽  
Author(s):  
Yu-Tao Liu ◽  
Xiao-Hong Han ◽  
Pu-Yuan Xing ◽  
Xing-Sheng Hu ◽  
Xue-Zhi Hao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Circular Rna ◽  
Small Cell ◽  
Small Cell Lung ◽  
Rna Profiling

scholarly journals Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells

RNA Biology ◽  
2019 ◽  
Vol 16 (2) ◽  
pp. 220-232 ◽  
Author(s):  
Ju Zhang ◽  
Xiuli Zhang ◽  
Cuidan Li ◽  
Liya Yue ◽  
Nan Ding ◽  
...  
Keyword(s):  
Subcellular Distribution ◽  
Hepg2 Cells ◽  
Circular Rna ◽  
Molecular Characteristics ◽  
Rna Profiling

Abstract 281: Evaluation of circular RNA profiling in metastatic melanoma patients treated with immune checkpoint blockade

2020 ◽  
Author(s):  
Juan Luis Onieva ◽  
Javier Oliver ◽  
Aurora Laborda-Illanes ◽  
Maria Rosario Chica-Parrado ◽  
Alicia Garrido-Aranda ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Immune Checkpoint ◽  
Circular Rna ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Rna Profiling ◽  
Melanoma Patients

Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin

2020 ◽  
Author(s):  
Shaomin Yang ◽  
Hong Zhou ◽  
Ruth Cruz-Cosme ◽  
Mingde Liu ◽  
Jiayu Xu ◽  
...  
Keyword(s):  
De Novo ◽  
Splice Junction ◽  
Circular Rna ◽  
Circular Rnas ◽  
Sequencing Data ◽  
Rna Profiling ◽  
Systematic Strategy ◽  
Coronavirus Infection ◽  
Abundance And Diversity ◽  
First Time

ABSTRACTCircular RNAs (circRNAs) encoded by DNA genomes have been identified across host and pathogen species as parts of the transcriptome. Accumulating evidences indicate that circRNAs play critical roles in autoimmune diseases and viral pathogenesis. Here we report that RNA viruses of the Betacoronavirus genus of Coronaviridae, SARS-CoV-2, SARS-CoV and MERS-CoV, encode a novel type of circRNAs. Through de novo circRNA analyses of publicly available coronavirus-infection related deep RNA-Sequencing data, we identified 351, 224 and 2,764 circRNAs derived from SARS-CoV-2, SARS-CoV and MERS-CoV, respectively, and characterized two major back-splice events shared by these viruses. Coronavirus-derived circRNAs are more abundant and longer compared to host genome-derived circRNAs. Using a systematic strategy to amplify and identify back-splice junction sequences, we experimentally identified over 100 viral circRNAs from SARS-CoV-2 infected Vero E6 cells. This collection of circRNAs provided the first line of evidence for the abundance and diversity of coronavirus-derived circRNAs and suggested possible mechanisms driving circRNA biogenesis from RNA genomes. Our findings highlight circRNAs as an important component of the coronavirus transcriptome.SummaryWe report for the first time that abundant and diverse circRNAs are generated by SARS-CoV-2, SARS-CoV and MERS-CoV and represent a novel type of circRNAs that differ from circRNAs encoded by DNA genomes.

scholarly journals Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer [Corrigendum]

2020 ◽  
Vol Volume 12 ◽  
pp. 9721-9724
Author(s):  
Weiyuan Wei ◽  
Xianwei Mo ◽  
Linhai Yan ◽  
Mingwei Huang ◽  
Yang Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Circular Rna ◽  
Rna Profiling
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