scholarly journals Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis

2018 ◽  
Vol 298 (4) ◽  
pp. 697-704 ◽  
Author(s):  
Cheng Liu ◽  
Chongdong Liu ◽  
Qiushi Wang ◽  
Zhenyu Zhang
Keyword(s):  
Folic Acid ◽  
Gestational Hypertension ◽  
Meta Analysis ◽  
In Pregnancy ◽  
Risk Of Preeclampsia

scholarly journals Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (4) ◽  
pp. 667
Author(s):  
Kjerstine Breintoft ◽  
Regitze Pinnerup ◽  
Tine Brink Henriksen ◽  
Dorte Rytter ◽  
Niels Uldbjerg ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Cesarean Section ◽  
Placental Abruption ◽  
Gestational Hypertension ◽  
Adverse Pregnancy Outcome ◽  
Placenta Previa ◽  
Meta Analysis ◽  
Increased Risk ◽  
Spontaneous Hemoperitoneum ◽  
In Pregnancy

Background: This systematic review and meta-analysis summarizes the evidence for the association between endometriosis and adverse pregnancy outcome, including gestational hypertension, pre-eclampsia, low birth weight, and small for gestational age, preterm birth, placenta previa, placental abruption, cesarean section, stillbirth, postpartum hemorrhage, spontaneous hemoperitoneum in pregnancy, and spontaneous bowel perforation in pregnancy. Methods: We performed the literature review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), by searches in PubMed and EMBASE, until 1 November 2020 (PROSPERO ID CRD42020213999). We included peer-reviewed observational cohort studies and case-control studies and scored them according to the Newcastle–Ottawa Scale, to assess the risk of bias and confounding. Results: 39 studies were included. Women with endometriosis had an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth, compared to women without endometriosis. These results remained unchanged in sub-analyses, including studies on spontaneous pregnancies only. Spontaneous hemoperitoneum in pregnancy and bowel perforation seemed to be associated with endometriosis; however, the studies were few and did not meet the inclusion criteria. Conclusions: The literature shows that endometriosis is associated with an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth.

scholarly journals Maternal Antioxidant Levels in Pregnancy and Risk of Preeclampsia and Small for Gestational Age Birth: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135192 ◽  
Author(s):  
Jacqueline M. Cohen ◽  
Margaret Beddaoui ◽  
Michael S. Kramer ◽  
Robert W. Platt ◽  
Olga Basso ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Meta Analysis ◽  
In Pregnancy ◽  
Risk Of Preeclampsia

scholarly journals Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Valgerdur Steinthorsdottir ◽  
◽  
Ralph McGinnis ◽  
Nicholas O. Williams ◽  
Lilja Stefansdottir ◽  
...  
Keyword(s):  
Gestational Hypertension ◽  
Meta Analysis ◽  
Asian Women ◽  
Polygenic Risk Score ◽  
Fetal Health ◽  
Central Asian ◽  
Genome Wide ◽  
Maternal Genome ◽  
Asian Mothers ◽  
Risk Of Preeclampsia

AbstractPreeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

scholarly journals The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 24 ◽  
pp. 174-190
Author(s):  
Yahui Yu ◽  
Ximu Sun ◽  
Xinrui Wang ◽  
Xin Feng
Keyword(s):  
Systematic Review ◽  
Folic Acid ◽  
Cohort Studies ◽  
Assessment Tool ◽  
Gestational Hypertension ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Hypertensive Disorders Of Pregnancy ◽  
Cardiovascular Risks ◽  
Hypertensive Disorders

Purpose: Although folic acid (FA) supplementation has been shown to reduce general cardiovascular risks, its impact on hypertensive disorders of pregnancy (HDP) is unclear. We performed a systematic review and meta-analysis to clarify the association between FA and the risk of HDP (pre-eclampsia (PE) and gestational hypertension (GH)). Methods: PubMed, EmBase, and Cochrane Library were searched up to June 18, 2020, stratified by type of disease, initiation time of FA, form of FA and pre-conception Body Mass Index (BMI). The quality assessment of included studies was evaluated using Newcastle-Ottawa Scale (NOS) for cohort studies and Cochrane Collaboration’s Risk of Bias Assessment Tool for randomized controlled trials (RCTs). Between-study heterogeneity was quantified using Cochran’s Q-statistic and I2 statistics. Sensitivity analysis was performed by excluding the studies one by one, and publication bias was analyzed using funnel plots. Results: Twenty studies with 359041 patients were identified for inclusion in the meta-analysis which included 3 RCTs and 17 cohort studies. Pooled estimates showed RR of 0.83 (95%CI 0.74-0.93, P=0.0008) for association between low dose FA (LD-FA) and the risk of PE, but LD-FA was not associated with GH (RR 1.05, 95% CI 0.97-1.13, P=0.20). In addition, the results of subgroup analysis showed that post-conception LD-FA had a 31% decreased risk of PE (RR 0.69, 95% CI 0.59-0.80, P<0.00001), and LD-FA in patients with pre-conception BMI<25 kg/m2 had a 32% decreased risk of PE (RR 0.68, 95% CI 0.56-0.81, P<0.0001) Conclusions: LD-FA significantly decreased the risk of PE but not GH, and post-conception LD-FA and pre-conception BMI<25 kg/m2 were considered as protective factors to reduce the risk of PE.

scholarly journals P.076 Hypertensive disorders in pregnancy are strongly associated with future stroke and hypertension: A systematic review and meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S40-S41
Author(s):  
AR Switzer ◽  
EE Smith ◽  
A Ganesh
Keyword(s):  
Gestational Hypertension ◽  
Meta Analysis ◽  
Stroke Mortality ◽  
Case Control Studies ◽  
Stroke Subtype ◽  
Stroke Incidence ◽  
Hypertensive Disorders ◽  
Hazard Ratios ◽  
Hypertensive Disorders In Pregnancy ◽  
In Pregnancy

Background: We aimed to evaluate the association between hypertensive disorders in pregnancy (HDP) and future risk of stroke, stroke death, and hypertension. Methods: Systematic searches were performed in MEDLINE and EMBASE up to April 27th, 2020. Exposure of interest included the different types of HDP. Outcomes of interest included hypertension incidence, stroke incidence, stroke subtype, and stroke mortality. Results: Eighteen cohort and 1 case-control studies involving >10 million women were included in the meta-analysis. Pooled hazard ratios with 95% confidence interval generally adjusted for age at delivery, ethnicity, and vascular risk factors are listed in table 1. Conclusions: Increasing severities of HDP carry higher hazards of hypertension and stroke years later. HDP, including gestational hypertension alone, are also associated with future stroke mortality.

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