Impact of antibiotic resistance of pathogens and early vitrectomy on the prognosis of infectious endophthalmitis: a 10-year retrospective study

2019 ◽  
Vol 257 (4) ◽  
pp. 805-813 ◽  
Author(s):  
Eun Young Choi ◽  
Jae Yong Han ◽  
Hyukmin Lee ◽  
Sung Chul Lee ◽  
Hyoung Jun Koh ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Retrospective Study ◽  
Early Vitrectomy ◽  
Infectious Endophthalmitis

scholarly journals Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996-8

BMJ ◽  
1999 ◽  
Vol 319 (7219) ◽  
pp. 1239-1240 ◽  
Author(s):  
J T Magee ◽  
E. L Pritchard ◽  
K. A Fitzgerald ◽  
F D J Dunstan ◽  
A J Howard
Keyword(s):  
Antibiotic Resistance ◽  
Retrospective Study ◽  
Antibiotic Prescribing ◽  
Community Practice

ANTIBIOTICS RESISTANCE AND OUTCOMES OF SEPSIS IN HUE CENTRAL HOSPITAL FROM 2009 TO 2010

2011 ◽  
pp. 53-57
Author(s):  
Thi Phuong Thao Nguyen ◽  
Xuan Chuong Tran
Keyword(s):  
Antibiotic Resistance ◽  
Retrospective Study ◽  
High Mortality ◽  
Streptococcus Suis ◽  
Antibiotics Resistance ◽  
Central Hospital ◽  
E Coli ◽  
Study Results ◽  
The Right ◽  
Very High

Objective: Sepsis is a very important infection. Studying the antibiotic resistance helps doctors to make the right choice for treatment of infections and reduce mortality. Materials and methods: 60 patients diagnosed as sepsis treated at Hue Central hospital, since Jan 2009 to June 2010. Retrospective study. Results: The most isolated agents are E. coli (40% patients), K. pneumoniae (16.7%) and Streptococcus suis (18.3%). Most of agents sensitive to ceftriaxon, ciprofloxacin và gentamicin. 100% sensitive to imipenem. All agents, except S. suis, are resistant to ampicillin. Agents resistant to ceftriaxon, ciprofloxacin and gentamicin have very high mortality (E. coli: 87.5% vs. 43.7%. S. suis : 66.7% vs. 25%). Conclusions: The most isolated agents are E. coli, K. pneumoniae and S. suis. Most of agents sensitive to ceftriaxon, ciprofloxacin và gentamicin. All agents, except S. suis, are resistant to ampicillin. Agents resistant to ceftriaxon, ciprofloxacin and gentamicin have very high mortality.

scholarly journals 2291. Evaluation of Multidrug-Resistant Pseudomonas aeruginosa Isolates in Patients Receiving Ceftolozane/tazobactam

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S785-S785
Author(s):  
Emily C Bodo ◽  
Aisling Caffrey ◽  
Vrishali Lopes ◽  
Jaclyn A Cusumano ◽  
Laura A Puzniak ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Retrospective Study ◽  
Carbapenem Resistance ◽  
Multidrug Resistant ◽  
Veterans Affairs ◽  
Carbapenem Resistant ◽  
Clinical Culture ◽  
Resistance Rates ◽  
Lactamase Inhibitor

Abstract Background Multidrug-resistant (MDR) Pseudomonas aeruginosa is a challenging pathogen to treat. Ceftolozane/tazobactam (C/T) is a combination cephalosporin and β-lactamase inhibitor that has demonstrated activity against MDR P. aeruginosa, including carbapenem-resistant isolates. The objective of this study was to evaluate multidrug resistance in P. aeruginosa isolates obtained from patients treated with C/T across the Veterans Affairs (VA) Healthcare System nationally. Methods Hospitalized patients who received at least 1 dose of CT between January 2015 and April 2018 and had a positive P. aeruginosa culture were included in this retrospective study. Culture source and antimicrobial susceptibility reports were assessed for each P. aeruginosa isolate. Isolates were categorized as multidrug-resistant based on the Centers for Disease Control (CDC) definition. Resistance rates were categorized by source of culture. Results We identified 174 positive P. aeruginosa cultures among 154 patients who received at least one dose of C/T during the study period. The most common sources of isolates were lung (40% of patients), urine (21%), skin and soft tissue (15%), blood (14%), and bone/joint (14%). Most patients (98.1%) had isolates that were MDR, with high rates of carbapenem (84.4%), extended-spectrum cephalosporin (82.5%), and fluoroquinolone (79.9%) resistance. In this cohort, 50.6% of patients received at least one antibiotic prior to initiating C/T to which their clinical culture was not susceptible. Conclusion Antibiotic resistance was high in this cohort of patients with P. aeruginosa, and as a result, use of non-susceptible antibiotics occurred in 50.6% of patients before C/T was started. The high carbapenem resistance rates are of great clinical concern, but highlight an area of utilization for C/T given its activity against carbapenem-resistant P. aeruginosa. Disclosures All authors: No reported disclosures.

scholarly journals Use of Antimicrobials in a French Veterinary Teaching Hospital: A Retrospective Study

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1369
Author(s):  
Caroline Prouillac
Keyword(s):  
Antibiotic Resistance ◽  
Retrospective Study ◽  
Teaching Hospital ◽  
Broad Spectrum ◽  
First Generation ◽  
Animal Health ◽  
Companion Animals ◽  
National Scale ◽  
Before And After ◽  
Veterinary School

Antibiotic resistance has become a major concern for not only human health, but also for animal health. To preserve the efficacy of antibiotics, it has become essential to establish measures to regulate the prescription of antibiotics to ensure their prudent use. In France, these measures have been translated into regulations for animal health since 2015, with the publication of three important regulatory texts. The results obtained on a national scale in terms of reducing the use of antibiotics have been satisfactory. The aim of our study was to evaluate the differences related to the prescription of antimicrobials at the veterinary teaching hospital of the Veterinary School of Lyon (CHUV) before and after the implementation of French regulations. Prescriptions and consumption of antimicrobials were examined, along with bacteriological analyses, for the period of 2014–2020, for companion animals and horses. The most frequently prescribed compounds were broad-spectrum antimicrobials, including penicillins with β-lactamase inhibitors, as well as first-generation cephalosporins tetracyclines and sulfamides. The prescription and consumption of critically important antibiotics (CIA) strongly decreased during the study period, with an increase of bacteriological analyses. This study shows the interest of having computerized tools to monitor the use of antimicrobials to implement corrective measures if needed.

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