A case?control study of occupational exposures and systemic sclerosis

2004 ◽  
Vol 77 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Massimo Bovenzi ◽  
Fabio Barbone ◽  
Federica E. Pisa ◽  
Alberto Betta ◽  
Luciano Romeo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Control Study

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

2018 ◽  
Vol 15 (1) ◽  
pp. 74-78
Author(s):  
Mohammadali Nazarinia ◽  
Asghar Zare ◽  
Mohammad javad Fallahi ◽  
Mesbah Shams
Keyword(s):  
Systemic Sclerosis ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Control Group ◽  
Lung Involvement ◽  
Serum Homocysteine ◽  
The Mean ◽  
Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

Predictors of inpatient mortality in patients with systemic sclerosis: a case control study

2016 ◽  
Vol 35 (6) ◽  
pp. 1631-1635 ◽  
Author(s):  
Shiv T. Sehra ◽  
Andrew Kelly ◽  
Joshua F. Baker ◽  
Chris T. Derk
Keyword(s):  
Systemic Sclerosis ◽  
Case Control Study ◽  
Case Control ◽  
Inpatient Mortality ◽  
Control Study

scholarly journals Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

2018 ◽  
Vol 75 (5) ◽  
pp. 328-336 ◽  
Author(s):  
Régis Colin ◽  
Michel Grzebyk ◽  
Pascal Wild ◽  
Guy Hédelin ◽  
Ève Bourgkard
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Metalworking Fluids ◽  
Cumulative Exposure ◽  
Cancer Case ◽  
Increased Risk ◽  
Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

scholarly journals Pulmonary vascular function at exercise in systemic sclerosis: A case-control study

2020 ◽  
Vol 12 (1) ◽  
pp. 57
Author(s):  
A. Rimouche ◽  
S. Caravita ◽  
C. Dewachter ◽  
A. Bondue ◽  
J.L. Vachiéry
Keyword(s):  
Systemic Sclerosis ◽  
Vascular Function ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Case–control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962–2010

2020 ◽  
Vol 122 (8) ◽  
pp. 1250-1259
Author(s):  
Gerald M. Kendall ◽  
Kathryn J. Bunch ◽  
Charles A. Stiller ◽  
Timothy J. Vincent ◽  
Michael F. G. Murphy
Keyword(s):  
Great Britain ◽  
Soft Tissue ◽  
Case Control Study ◽  
Soft Tissue Sarcomas ◽  
Occupational Exposures ◽  
Case Control ◽  
Bone Tumours ◽  
Control Study

scholarly journals 0473 Sinonasal cancers and occupational exposures, a population-based case-control study

2017 ◽  
Author(s):  
Carolina Mensi ◽  
Michele Carugno ◽  
Angela Cecilia Pesatori ◽  
Barbara Dallari ◽  
Luciano Riboldi ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals The risk of asthma in relation to occupational exposures: a case–control study from a Swedish city

1999 ◽  
Vol 13 (3) ◽  
pp. 496-501 ◽  
Author(s):  
K. Torén ◽  
B. Balder ◽  
J. Brisman ◽  
N. Lindholm ◽  
O. Löwhagen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Control Study
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