The abnormalities of carbohydrate metabolism in Turner syndrome: analysis of risk factors associated with impaired glucose tolerance

2005 ◽  
Vol 164 (7) ◽  
pp. 442-447 ◽  
Author(s):  
In Kyoung Choi ◽  
Duk Hee Kim ◽  
Ho-Seong Kim
Author(s):  
Srivastava Rajat ◽  
Bhide GD

Background: Hypertension is an acute public health problem both in developed and in developing countries, like India. It remains silent, being generally asymptomatic during its clinical course. As it is hidden beneath an outwardly asymptomatic appearance, the disease does immense harm to the body in the form of 'Target Organ' damage; hence, the WHO has named it the 'Silent Killer'1. Job related psychosocial stress and sedentary life styles may directly and indirectly contribute to development of hypertension2. With urbanization, the problem of hypertension is growing rapidly to epidemic levels in the developing countries. This invisible epidemic is an underappreciated cause of poverty and hinders the economic development of many countries3. Assessing the association of risk factors with Hypertension in the community is equivalent to assessing the submerged portion of the iceberg which is so much more obscure. Objective: To carry out an Observational study amongst civil population of Bhopal to successfully determine the risk factors associated with Hypertension. Materials and Methods: 375 randomly selected individuals were subjected to check of blood pressure with two readings being taken by two different examiners at an interval of 15 minutes. Subsequently 157 individuals found Hypertensive were further screened for risk factors for Hypertension by measuring height, weight, BMI, serum total cholesterol, serum triglycerides, serum HDL, random blood sugar levels, physical activity, smoking status & alcohol consumption. Results: Out of 375 individuals screened, 157 individuals were found to be having high blood pressure. About 15.4% were found to be obese with BMI > 23Kg/m2, 22% had hypercholesterolemia, 5.4% had IGT (Impaired Glucose Tolerance), 19.2% were current smokers and 3.4% were alcohol consumers. Higher age, BMI (Body Mass Index), high serum triglycerides, low serum HDL, IGT (Impaired Glucose Tolerance) and lack of exercising were found to be independently associated with Hypertension in multiple logistic regression analysis. Conclusion: Our findings recommend the constant monitoring of risk factors for Hypertension and the formulation of effective preventive strategies for adequate control of its alarming incidence. Keywords: Hypertension, Impaired Glucose Tolerance, Body Mass Index, High Density Lipoprotein, Coronary Heart Disease.


2013 ◽  
Author(s):  
Guillermo Martinez ◽  
Gonzalo Allo ◽  
Ana Fernandez ◽  
Mercedes Aramendi ◽  
Carlos Jimenez ◽  
...  

2009 ◽  
Vol 6 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Markolf Hanefeld ◽  
Avraham Karasik ◽  
Carsta Koehler ◽  
Torsten Westermeier ◽  
Jean-Louis Chiasson

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Anshul Saxena ◽  
Muni Rubens ◽  
Venkataraghavan Ramamoorthy ◽  
Sankalp Das ◽  
Chintan B Bhatt ◽  
...  

Introduction: Cardiometabolic syndrome consists of a cluster of metabolic dysfunctions such as impaired glucose tolerance, insulin resistance, dyslipidemia, central adiposity, and hypertension. According to the latest estimates, globally, nearly 25% of all adults have cardiometabolic syndrome. Both cardiometabolic syndrome and cancer pathophysiology commonly involve inflammation and oxidative stress. The objective of this systematic review was to evaluate existing evidences that support the association between cardiometabolic syndrome and risk of developing cancer. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Scopus for relevant articles published from the database inception until October 2019. We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for this review. Using the Oxford Center for Evidence-Based Medicine guidelines individual studies were evaluated. A total of 59 articles were included in this study. Results: Our review showed that cardiometabolic syndrome was associated with increased risk for colorectal, hepatic, endometrial, breast, and bladder cancers. These associations showed variations for sex and geographical locations. For example, the associations were stronger for pancreatic and rectal cancers among women. The strength of these associations was also stronger for sex specific cancers such as breast and endometrial cancers. Studies on European populations showed that these associations were stronger for colorectal cancer among women. However, one study showed that presence of cardiometabolic syndrome contributed protective effects to prostate cancer among American men. In general, strongest associations were found for colorectal cancer among both men and women and hepatic cancer among men. Among cardiometabolic factors, impaired glucose tolerance and central adiposity were the greatest contributors towards increased risk for cancers. Conclusion: Given these results, there should be greater focus on primary prevention to identify and treat cardiometabolic risk factors. In addition, patients with greater cardiometabolic risk factors should be screened earlier and more frequently for cancers. A number of gender and geographical gaps identified in this review could be targeted for improvements as per the goals of 2030 sustainable development initiatives. Future studies should consider cardiometabolic syndrome and cancer together and develop effective interventions for decreasing the incidence and morbidity associated with both the conditions.


Sign in / Sign up

Export Citation Format

Share Document