scholarly journals Clinical manifestations of COVID-19 in the general population: systematic review

2020 ◽  
Author(s):  
Rodrigo da Rosa Mesquita ◽  
Luiz Carlos Francelino Silva Junior ◽  
Fernanda Mayara Santos Santana ◽  
Tatiana Farias de Oliveira ◽  
Rafaela Campos Alcântara ◽  
...  
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Clinical Manifestations

scholarly journals COVID-19 and Hemoglobinopathies: A Systematic Review of Clinical Presentations, Investigations, and Outcomes

2021 ◽  
Vol 8 ◽  
Author(s):  
Jun Xin Lee ◽  
Wei Keong Chieng ◽  
Sie Chong Doris Lau ◽  
Chai Eng Tan
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Critical Appraisal ◽  
Web Of Science ◽  
Clinical Manifestations ◽  
Cell Disease ◽  
Oxygen Supplementation ◽  
Clinical Trial Registration ◽  
Course Of Illness ◽  
Clinical Presentations

This systematic review aimed to provide an overview of the clinical profile and outcome of COVID-19 infection in patients with hemoglobinopathy. The rate of COVID-19 mortality and its predictors were also identified. A systematic search was conducted in accordance with PRISMA guidelines in five electronic databases (PubMed, Scopus, Web of Science, Embase, WHO COVID-19 database) for articles published between 1st December 2019 to 31st October 2020. All articles with laboratory-confirmed COVID-19 cases with underlying hemoglobinopathy were included. Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklists. Thirty-one articles with data on 246 patients with hemoglobinopathy were included in this review. In general, clinical manifestations of COVID-19 infection among patients with hemoglobinopathy were similar to the general population. Vaso-occlusive crisis occurred in 55.6% of sickle cell disease patients with COVID-19 infection. Mortality from COVID-19 infection among patients with hemoglobinopathy was 6.9%. After adjusting for age, gender, types of hemoglobinopathy and oxygen supplementation, respiratory (adj OR = 89.63, 95% CI 2.514–3195.537, p = 0.014) and cardiovascular (adj OR = 35.20, 95% CI 1.291–959.526, p = 0.035) comorbidities were significant predictors of mortality. Patients with hemoglobinopathy had a higher mortality rate from COVID-19 infection compared to the general population. Those with coexisting cardiovascular or respiratory comorbidities require closer monitoring during the course of illness. More data are needed to allow a better understanding on the clinical impact of COVID-19 infections among patients with hemoglobinopathy.Clinical Trial Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020218200.

scholarly journals Pandemic of COVID-19 and Pregnancy

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 206-212
Author(s):  
Shaherzad Sohail ◽  
Lubna Raiz Dar
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Breast Feeding ◽  
Clinical Manifestations ◽  
Health Concern ◽  
High Risk Population ◽  
Clinical Practices ◽  
Pregnant Females

<p><strong>Background and Objective:</strong> Infectious disease outbreak caused by novel Coronavirus is a global public health concern. In this pandemic, pregnant women are high risk population. Knowledge and data on the effect of this COVID-19 disease on pregnant females and their newborns is limited. Number of cases is increasing day by day. Aim of the current study was to provide evidence-based knowledge related to effects of Coronavirus on pregnancy to improve the understanding of the COVID-19 disease. <strong>Methods: </strong>This is a systematic review, carried out in the Department of Obstetrics &amp; Gynecology at Shalamar Medical and Dental College, Lahore. The available published research data from January 1st 2020 to May 13th 2020, on the effects of Coronavirus in pregnancy was collected. On the basis of Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines the articles in English were selected from electronic databases PubMed and Goggle scholar. <strong>Results: </strong>The information gathered is organized in five main themes namely; Clinical manifestations of COVID-19 during pregnancy, risk of vertical transmission, issues related to breast feeding, care during antenatal period and labor and strategies for prevention. The main concern is to focus on best clinical practices for care of pregnant females. <strong>Conclusion:</strong> Clinical manifestations of Coronavirus infection in pregnant females are not different from general population. There is on strong evidence of risk of vertical transmission. Best antenatal care and care during labor is the right of all pregnant females whether suspected or infected and it must be according to the standardized guidelines. Breast feeding is encouraged either with full protection of transmission of droplet infection or my expressing milk manually. Vaginal delivery is safe and preventive strategies for the disease available for general population must be adapted by the pregnant women also to avoid getting the infection.</p>

scholarly journals The Prevalence of Sarcopenia and Its Impact on Clinical Outcomes in Lumbar Degenerative Spine Disease—A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (4) ◽  
pp. 773
Author(s):  
Wei-Ting Wu ◽  
Tsung-Min Lee ◽  
Der-Sheng Han ◽  
Ke-Vin Chang
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Clinical Manifestations ◽  
Current Evidence ◽  
Degenerative Spine ◽  
Degenerative Spine Disease ◽  
Spine Disease

The association of sarcopenia with poor clinical outcomes has been identified in various medical conditions, although there is a lack of quantitative analysis to validate the influence of sarcopenia on patients with lumbar degenerative spine disease (LDSD) from the available literature. Therefore, this systematic review and meta-analysis aimed to summarize the prevalence of sarcopenia in patients with LDSD and examine its impact on clinical outcomes. The electronic databases (PubMed and Embase) were systematically searched from inception through December 2020 for clinical studies investigating the association of sarcopenia with clinical outcomes in patients with LDSD. A random-effects model meta-analysis was carried out for data synthesis. This meta-analysis included 14 studies, comprising 1953 participants. The overall prevalence of sarcopenia among patients with LDSD was 24.8% (95% confidence interval [CI], 17.3%–34.3%). The relative risk of sarcopenia was not significantly increased in patients with LDSD compared with controls (risk ratio, 1.605; 95% CI, 0.321–8.022). The patients with sarcopenia did not experience an increase in low back and leg pain. However, lower quality of life (SMD, −0.627; 95% CI, −0.844–−0.410) were identified postoperatively. Sarcopenia did not lead to an elevated rate of complications after lumbar surgeries. Sarcopenia accounts for approximately one-quarter of the population with LDSD. The clinical manifestations are less influenced by sarcopenia, whereas sarcopenia is associated with poorer quality of life after lumbar surgeries. The current evidence is still insufficient to support sarcopenia as a predictor of postoperative complications.

The physiopathology of spontaneous hemorrhagic stroke: a systematic review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Alcivan Batista de Morais Filho ◽  
Thiago Luis de Holanda Rego ◽  
Letícia de Lima Mendonça ◽  
Sulyanne Saraiva de Almeida ◽  
Mariana Lima da Nóbrega ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Natural History ◽  
Hemorrhagic Stroke ◽  
Recent Literature ◽  
Clinical Manifestations ◽  
The Road ◽  
History Of

Abstract Hemorrhagic stroke (HS) is a major cause of death and disability worldwide, despite being less common, it presents more aggressively and leads to more severe sequelae than ischemic stroke. There are two types of HS: Intracerebral Hemorrhage (ICH) and Subarachnoid Hemorrhage (SAH), differing not only in the site of bleeding, but also in the mechanisms responsible for acute and subacute symptoms. This is a systematic review of databases in search of works of the last five years relating to the comprehension of both kinds of HS. Sixty two articles composed the direct findings of the recent literature and were further characterized to construct the pathophysiology in the order of events. The road to the understanding of the spontaneous HS pathophysiology is far from complete. Our findings show specific and individual results relating to the natural history of the disease of ICH and SAH, presenting common and different risk factors, distinct and similar clinical manifestations at onset or later days to weeks, and possible complications for both.

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