Analogue modeling of the role of multi-level decollement layers on the geometry of orogenic wedge: an application to the Zagros Fold–Thrust Belt, SW Iran

2017 ◽  
Vol 106 (8) ◽  
pp. 2837-2853 ◽  
Author(s):  
Mostafa Ghanadian ◽  
Ali Faghih ◽  
Bernhard Grasemann ◽  
Iraj Abdollahie Fard ◽  
Mehrdad Maleki
Keyword(s):  
Thrust Belt ◽  
Analogue Modeling ◽  
Orogenic Wedge ◽  
Sw Iran ◽  
Multi Level

scholarly journals Role of the Early Miocene Jinhe-Qinghe Thrust Belt in the building of the Southeastern Tibetan Plateau topography

2021 ◽  
Vol 811 ◽  
pp. 228871
Author(s):  
Chengyu Zhu ◽  
Guocan Wang ◽  
Philippe Hervé Leloup ◽  
Kai Cao ◽  
Gweltaz Mahéo ◽  
...  
Keyword(s):  
Tibetan Plateau ◽  
Early Miocene ◽  
Thrust Belt ◽  
Southeastern Tibetan Plateau

scholarly journals The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3949
Author(s):  
Federica Rascio ◽  
Federica Spadaccino ◽  
Maria Teresa Rocchetti ◽  
Giuseppe Castellano ◽  
Giovanni Stallone ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Akt Pathway ◽  
Invasion And Metastasis ◽  
Pathogenic Role ◽  
Multiple Cancer ◽  
Downstream Target ◽  
Cancer Types ◽  
Multi Level ◽  
Survival Mechanisms

The PI3K/AKT pathway is one of the most frequently over-activated intracellular pathways in several human cancers. This pathway, acting on different downstream target proteins, contributes to the carcinogenesis, proliferation, invasion, and metastasis of tumour cells. A multi-level impairment, involving mutation and genetic alteration, aberrant regulation of miRNAs sequences, and abnormal phosphorylation of cascade factors, has been found in multiple cancer types. The deregulation of this pathway counteracts common therapeutic strategies and contributes to multidrug resistance. In this review, we underline the involvement of this pathway in patho-physiological cell survival mechanisms, emphasizing its key role in the development of drug resistance. We also provide an overview of the potential inhibition strategies currently available.

scholarly journals Redefining the learning space: Developing peer mentoring in the enterprise curriculum

2020 ◽  
pp. 095042222098126
Author(s):  
Andrew P Hird
Keyword(s):  
Learning Environment ◽  
Peer Mentoring ◽  
Learning Space ◽  
Hygiene Factors ◽  
Multi Level ◽  
Considerable Strain

This account of practice seeks to demystify the entrepreneurship classroom and to provide practical insights into the successful introduction and embedding of a multi-level peer mentoring scheme. Over a 5-year period, peer mentoring has been embedded in an undergraduate enterprise curriculum. This has posed challenges to a number of taken-for-granted assumptions about the enterprise classroom. The role of the tutor in the classroom was redefined; the roles of both colleagues and students were questioned. The accepted rules and norms of the learning environment were placed under considerable strain. It was found that both colleagues and students had very clearly defined expectations of one another and their respective roles: these proved difficult to change. The article recounts the journey, and how the organisers learned to accept and embrace the difficulties faced. Hygiene factors such as timetabling and communication were highly important in allowing the interactions to take place, as were socialisation and facilitation. The mistakes made are also recounted so that they can be avoided by other practitioners.

scholarly journals Building Bridges: A Participatory Stakeholder Framework for Sustainable Urban Construction Logistics

2021 ◽  
Vol 13 (5) ◽  
pp. 2678
Author(s):  
Nicolas Brusselaers ◽  
Koen Mommens ◽  
Cathy Macharis
Keyword(s):  
Urban Areas ◽  
Sustainable Construction ◽  
Environmental Footprint ◽  
Implementation Barriers ◽  
Urban Construction ◽  
Multi Level ◽  
Negative Impacts ◽  
Roll Out ◽  
Construction Works

The urban built environment concentrates due to the growing urbanization trend, triggering construction and renovation works in urban areas. Although construction works often revitalize cities upon completion, the associated logistics activities engender a significant financial and environmental footprint if not handled appropriately. Cities have the largest potential to reduce negative impacts through requirements on construction logistics. However, today, there is a lack of knowledge within cities on how to set such demands and how to involve and manage the numerous and varying stakeholders in these processes. This paper presents a participatory decision-making framework for the governance of urban construction logistics on economic, environmental and societal levels, building further on the Multi-Actor Multi-Criteria Analysis (MAMCA). The framework was then implemented on a use case in the dense urban Brussels-Capital Region (Belgium), gathering a wide variety of stakeholders in the context of a sustainable Construction Logistics Scenario (CLS) evaluation. Special attention was paid on the identification of implementation barriers and the role of governments to facilitate the introduction and city-wide roll-out of novel CLS. Findings show how different processes are site-, actor- and condition-specific, thereby delivering a common built object which is often based on different motivations and concerns. The study proposes a flexible, replicable and upscalable framework both from an inter- and intracity perspective, which can serve to support (1) the management of processes and CLS, (2) the management of people and the community, and (3) the project and city, in the context of multi-level governance.

scholarly journals A new insight into role of phosphoketolase pathway in Synechocystis sp. PCC 6803

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anushree Bachhar ◽  
Jiri Jablonsky
Keyword(s):  
In Silico Analysis ◽  
Bioinformatic Analysis ◽  
Phosphoglycerate Mutase ◽  
Phosphoketolase Pathway ◽  
Multi Level ◽  
Silico Analysis ◽  
Insight Into ◽  
Synechocystis Sp ◽  
Pcc 6803

AbstractPhosphoketolase (PKET) pathway is predominant in cyanobacteria (around 98%) but current opinion is that it is virtually inactive under autotrophic ambient CO2 condition (AC-auto). This creates an evolutionary paradox due to the existence of PKET pathway in obligatory photoautotrophs. We aim to answer the paradox with the aid of bioinformatic analysis along with metabolic, transcriptomic, fluxomic and mutant data integrated into a multi-level kinetic model. We discussed the problems linked to neglected isozyme, pket2 (sll0529) and inconsistencies towards the explanation of residual flux via PKET pathway in the case of silenced pket1 (slr0453) in Synechocystis sp. PCC 6803. Our in silico analysis showed: (1) 17% flux reduction via RuBisCO for Δpket1 under AC-auto, (2) 11.2–14.3% growth decrease for Δpket2 in turbulent AC-auto, and (3) flux via PKET pathway reaching up to 252% of the flux via phosphoglycerate mutase under AC-auto. All results imply that PKET pathway plays a crucial role under AC-auto by mitigating the decarboxylation occurring in OPP pathway and conversion of pyruvate to acetyl CoA linked to EMP glycolysis under the carbon scarce environment. Finally, our model predicted that PKETs have low affinity to S7P as a substrate.

scholarly journals Multi-level climate governance and the role of the subnational level

2015 ◽  
Vol 12 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Kirsten Jörgensen ◽  
Anu Jogesh ◽  
Arabinda Mishra
Keyword(s):  
Climate Governance ◽  
Multi Level

Italy and the politics of European defence: playing by the logic of multi-level networks

Modern Italy ◽  
2004 ◽  
Vol 9 (2) ◽  
pp. 217-231 ◽  
Author(s):  
Paolo Foradori ◽  
Paolo Rosa
Keyword(s):  
Decision Making ◽  
Security Policy ◽  
European Level ◽  
Foreign And Security Policy ◽  
Multi Level ◽  
The Eu ◽  
Common Defence

SummaryThe article looks at the role of Italy in the decision-making arena of the EU Common Foreign and Security Policy (CFSP), analysing the initiatives it put in place to address and influence the construction of a common defence. The article aims to explain the ability or inability of Italy to build up a consensus around its proposals. By studying two initiatives in the field of European defence and security, it seeks to determine the factors which resulted in the differing outcomes of Italian actions at the European level.

scholarly journals University alliances in the Europe of knowledge: Positions, agendas and practices in policy processes

2017 ◽  
Vol 17 (3) ◽  
pp. 349-364 ◽  
Author(s):  
Martina Vukasovic ◽  
Bjørn Stensaker
Keyword(s):  
Higher Education ◽  
Policy Formation ◽  
European Level ◽  
Knowledge Domain ◽  
Policy Domain ◽  
Multi Level ◽  
Policy Agendas ◽  
Research And Education ◽  
Policy Arena

Several university alliances have been established in Europe in an attempt to influence the development of policies in research and education. As such, these alliances can be seen as being new players in the increasingly complex multi-actor, multi-level governance in this policy domain. The paper compares two key university alliances in Europe; in particular, how membership differences are related to their positions in the policy arena, their policy agendas and their policy formation and lobbying practices. The study contributes to understanding of, first, the role of university alliances in European level policy processes concerning higher education and research; and, second, the implications their involvement might have for future shaping of European initiatives in the knowledge domain.

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