The therapeutic potential of aqueous extract of Falcaria vulgaris in the treatment of fatty liver disease: a histopathological and biochemical approach

Sirtuins (SIRTs) are members of the silent information regulator-2 family and act as nicotinamide adenine dinucleotide (NAD+)-dependent histone/protein deacetylases. The de-acetylation of proteins and histones results in an up- or down-regulation of gene transcription and protein function. In recent years, the regulatory action of the deacetylation activity of SIRT1 has been shown to have a positive impact on the pathophysiological mechanisms of nonalcoholic fatty liver disease (NAFLD). Among the effects of SIRT1 are: its healing activity on insulin sensitivity, thereby ameliorating glycemic regulation; its mimetic activity on calorie restriction; its antihyperlipidemic activity on lipid homeostasis via the liver, adipose tissues and skeletal muscles; its antiinflammatory activities; its protective effects against cardiovascular events and endothelial dysfunction; its positive influence on autophagy, apoptosis and cancer; and finally, its anti-aging activity. The current approach for the treatment of NAFLD involves the treatment of etiological factors and recommendation of life-style changes including more physical activity and a low-calorie diet. However, there are no specific medical treatments for NAFLD. The therapeutic potential of SIRT1 activity in the treatment of NAFLD discovered in humans has been presented in this article. In this review, the potential effects of SIRT1 activation on NAFLD-related pathophysiological mechanisms and on the treatment of NAFLD are discussed.

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Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease

European Journal of Pharmacology ◽

10.1016/j.ejphar.2019.01.039 ◽

2019 ◽

Vol 847 ◽

pp. 72-82 ◽

Cited By ~ 5

Author(s):

Marwa B. Bakir ◽

Mona A. Salama ◽

Rowaida Refaat ◽

Mennatallah A. Ali ◽

Eman A. Khalifa ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Therapeutic Potential ◽

Nonalcoholic Fatty Liver

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New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

PLoS ONE ◽

10.1371/journal.pone.0172900 ◽

2017 ◽

Vol 12 (3) ◽

pp. e0172900 ◽

Cited By ~ 20

Author(s):

María Eugenia Inzaugarat ◽

Elena De Matteo ◽

Placida Baz ◽

Diego Lucero ◽

Cecilia Claudia García ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Therapeutic Potential ◽

Nonalcoholic Fatty Liver ◽

New Evidence

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Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

Nutrients ◽

10.3390/nu11040872 ◽

2019 ◽

Vol 11 (4) ◽

pp. 872 ◽

Cited By ~ 42

Author(s):

Jinchunzi Yang ◽

Marta Fernández-Galilea ◽

Leyre Martínez-Fernández ◽

Pedro González-Muniesa ◽

Adriana Pérez-Chávez ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Metabolic Diseases ◽

Therapeutic Potential ◽

Omega 3 ◽

Alcoholic Fatty Liver ◽

Pufa Supplementation ◽

Alcoholic Fatty Liver Disease

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed.

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Effect of aqueous extract of Colocasia esculenta against high-fat diet-induced non-alcoholic fatty liver disease in rats

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs/lpr.2020.10.4.p128-134 ◽

2020 ◽

Vol 10 (4) ◽

Author(s):

Somasekhar Reddy Kanala ◽

Sudheer Akkiraju ◽

Likitha Sree Pamisetty ◽

Pradeepkumar Bhupalam ◽

Deepthi Dharmavaram ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Aqueous Extract ◽

High Fat Diet ◽

Fatty Liver Disease ◽

Colocasia Esculenta ◽

High Fat ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Histological Effects of Aqueous Extract of Moringa oleifera on the Liver Tissues of Wistar rats fed with High Fat Diet

International Journal of Forensic Medical Investigation ◽

10.21816/ijfmi.v2i2.38 ◽

2017 ◽

Vol 2 (2) ◽

pp. 1

Author(s):

Obayuwana E, Obayuwana E, Ubehenin A.E, Innih S.O, Iwee R, Eidaghese E.C

Keyword(s):

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Aqueous Extract ◽

High Fat Diet ◽

Fatty Liver Disease ◽

Moringa Oleifera ◽

High Fat ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Moringa oleifera belongs to family of moringaceae and is considered as one of the world’s most useful trees, as almost every part of the plant can be used for either as food, or therapeutic purposes. Fatty diet is a significant factor in the pathogenesis of non-alcoholic fatty Liver disease (NAFLD). The study was designed to examine histological effects of aqueous extract of Moringa oleifera on the liver tissues of wistar rat fed with high fat diet. Twenty five adult rats were divided into five groups of five animals each .While group A received distilled water daily only, groups Band C received aqueous extract of Moringa oleifera at doses of 200 mg/kg body weight and fat high diet (30% w/w of the total mash feed) respectively for a duration of seventy days. Others (groups D and E) received aqueous extract of Moringa oleifera at doses of 200 mg/kg body weight and fat high diet for a duration of seventy days. Histology of the liver of the rats fed with high fat diet exhibited significant changes in the architecture of liver tissue. The changes include micro and macro vascular steatosis, increased fatty infiltration, inflammation, sinusoidal dilation, degeneration of veins and vacuolization as compared to normal liver histology. Treatment with 200 mg/kg extract of Moringa oleifera significantly attenuated these effects imposed by high fat diet as compared to the control group. Therefore demonstrated that daily administration of Moringa oleifera leaves extract to rats for a period of 70 days may reverse the formation of hepatic steatosis in non-alcoholic fatty liver disease.

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