Bone mineral density, body mass index, postmenopausal period and outcomes of low back pain treatment in Korean postmenopausal women

Background: Therapy with glucocorticoids often results in bone loss and glucocorticoidinduced osteoporosis. However, the relationship between epidural steroid injection (ESI), bone mineral density (BMD), and vertebral fracture remains to be determined. Objective: To establish a relationship between ESI, BMD, and vertebral fracture in postmenopausal women with low back pain. Study Design: This study was a retrospective, nonblinded, cross-sectional clinical study. Setting: University-based pain management center. Methods: We reviewed the medical records of postmenopausal women with low back pain who were treated with ESI. A total of 352 postmenopausal women were divided into 2 groups. Group 1 consisted of patients without fracture and Group 2 consisted of those with fractures. The results of BMD measurements, as well as any fragility fractures, the anatomical site involved, and the treatment administered, were also recorded. BMD was measured in the lumbar spine, femoral neck, and total femur after the treatment. Results: Of the 352 patients, 218 (62%) had no fractures while 134 (38%) sustained a fracture. The age was significantly higher among patients who sustained fractures, and BMD at the lumbar spine, total femur, and femoral neck regions was significantly lower among patients who sustained fractures. In each region, the prevalence of osteoporosis was significantly higher in patients with fracture than in patients without fracture (all P < 0.05). Age, height, and weight were associated with low BMD. However, our study showed no consistent correlation between BMD and the mean number of ESIs, mean total dose of glucocorticoids, or mean duration of ESIs. Limitations: First, this study is limited by the fact that it was retrospective. Second, the number of cases receiving very frequent, high-dose glucocorticoid injections was very small. Conclusions: Older age and lower BMD were associated with osteoporotic fracture in postmenopausal women treated for low back pain with ESI. The ESIs were not associated with low BMD or fracture. Key words: Bone mineral density, epidural steroid injection, fracture, glucocorticoids, low back pain, postmenopause.

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The relationship between body mass index and physical activity levels in relation to bone mineral density in premenopausal and postmenopausal women

Archives of Osteoporosis ◽

10.1007/s11657-013-0162-z ◽

2013 ◽

Vol 8 (1-2) ◽

Cited By ~ 21

Author(s):

James Wee ◽

Bo Yang Jonathan Sng ◽

Liang Shen ◽

Chin Tat Lim ◽

Gurpal Singh ◽

...

Keyword(s):

Physical Activity ◽

Bone Mineral Density ◽

Body Mass Index ◽

Postmenopausal Women ◽

Body Mass ◽

Bone Mineral ◽

Activity Levels ◽

Mineral Density ◽

Physical Activity Levels ◽

The Relationship

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Impact of three-dimensional chemoradiation on pelvic bone mineral density, low back pain, and disability in cervical cancer: a prospective study

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2020-002290 ◽

2021 ◽

pp. ijgc-2020-002290

Author(s):

Divyesh Kumar ◽

Raviteja Miriyala ◽

Bhavana Rai ◽

Pooja Bansal ◽

Arun S Oinam ◽

...

Keyword(s):

Bone Mineral Density ◽

Cervical Cancer ◽

Low Back Pain ◽

Back Pain ◽

Femoral Neck ◽

Bone Mineral ◽

Menopausal Status ◽

Pelvic Bone ◽

Low Back ◽

Mineral Density

ObjectiveTo prospectively analyze the effect of three-dimensional chemoradiation on the bone mineral density of pelvic bones and its association with low back pain and disability in patients with locally advanced cervical cancer.MethodsIn biopsy proven locally advanced cervical cancer patients, bone mineral density and T scores for lumbar vertebrae 5, dorsal thoracic vertebrae 12, and T scores for the femoral neck were analyzed. Low back pain was scored using the visual analog scale while disability scoring was done using the Oswestry low back pain disability scale. Furthermore, a subgroup analysis for patients (classified according to menopausal status) was performed.ResultsIn total, 106 patients were analyzed. A statistically significant decline in mean bone mineral density was observed at all three sites (vertebrae 5 and 12, and the femoral neck) post-chemoradiation therapy compared with pretreatment bone mineral density (0.671 vs 0.828, −2.083 vs −1.531, −2.503 vs −1.626; all p<0.001). Similarly, in subgroup analyses, at all three sites, pre-menopausal patients showed a statistically significant association (0.876 vs 0.697, −1.203 vs −0.2.761, –1.403 vs −2.232; all p<0.001) while a non-significant association was observed for post-menopausal patients at vertebrae 12 (−1.707 vs −1.719; p=0.09) with a statistically significant association at vertebrae 5 and the femoral neck (0.803 vs 0.656, –1.746 vs −2.648; p<0.01). Although statistically significant low back pain and disability scores were observed overall and irrespective of menopausal status, no correlation between bone mineral density and low back pain and disability was observed.ConclusionPelvic bone mineral density decreases significantly after chemoradiation, irrespective of menopausal status. However, no correlation with low back pain and disability was observed. Pelvic bone mineral density analysis should be considered before chemoradiation in cervical cancer.

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Effect of BMI(Body Mass Index) on BMD (Bone Mineral Density) in Postmenopausal Women

Journal of Dhaka Medical College ◽

10.3329/jdmc.v28i1.45758 ◽

2020 ◽

Vol 28 (1) ◽

pp. 60-66

Author(s):

Tabassum Ghani ◽

Subinoy Krishna Paul ◽

Afrina Begum ◽

Noorjahan ◽

Mandira Sarkar ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Bone Loss ◽

Postmenopausal Women ◽

Body Mass ◽

Bone Mineral ◽

Significant Positive Correlation ◽

Mineral Density ◽

Positive Correlation ◽

Medical College

Menopause is commonly associated with rapid bone loss and this bone loss manifests as a significant decrease in bone mineral density (BMD). Body weight or body mass index is the most important factor which influences BMD. Aim of this study was to evaluate the association between BMI and BMD in post menopausal women. Also to measure the correlation between age, duration of menopause, weight with BMD. This cross-sectional study was undertaken in the Department of Obstetrics and Gynaecology in Dhaka Medical College Hospital, Dhaka from January, 2012 to December, 2012. The study included women of 50 to 70 years who had menopause with three or more parity. Total 100 women were evaluated by history taking, physical examination and laboratory investigation (BMD).The results showed that there was significant positive correlation between BMI and BMD value of L1-4 and total femur (Pearson‘s coefficient was +0.285, P<0.01 and +.350, P<.001). There was also significant positive correlation between weight and T- score of L1-4 (r =+ .482, P<.01) and Total femur (r = +.513, P< .01). In addition, significant negative correlation was found between BMD with age and duration of menopause. It can be concluded that in postmenopausal women as the BMI decreases bone mineral density also decreases. So, adequate weight and BMI necessary for the prevention of osteoporosis. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 60-66

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Body Mass Index can be a Good Predictor of Bone Mineral Density in Postmenopausal Women in India

International Journal of Public Health Science (IJPHS) ◽

10.11591/.v3i4.4703 ◽

2014 ◽

Vol 3 (4) ◽

pp. 276

Author(s):

Biplob Chowdhury ◽

Brajanath Kundu

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Body Weight ◽

Postmenopausal Women ◽

Body Mass ◽

Bone Mineral ◽

Assessment Tool ◽

Negative Impact ◽

Mineral Density ◽

Women In India

Risk factors for the prediction of osteoporosis are an important and cost effective method since osteoporosis is a silent disease. The purpose of the study was to evaluate the associations between weight, body mass index (BMI), the Osteoporosis Self-Assessment Tool (OST), and bone mineral density (BMD) in postmenopausal women in India. In this cross sectional study, 90 postmenopausal women aged 45–85 years who had given consent participated and the study was conducted between April, 2012 and May, 2013. BMD was measured by ultrasound bone densitometry at calcaneal site. Linear regression multivariate models were used to examine the associations with weight, BMI, OST, and BMD. Body weight, BMI, and OST had almost similar overall performance in their ability to classify women with BMD T-score ≤−2.5. Regression results showed that the linear combination of three independent variables BMI, OST and body weight. BMI predicted 65.7% of the variance in BMD, R2 = .657, R2 adjusted = .609, (F=21.295, p<.000). The strongest predictor of low BMD was BMI. BMI showed significant association with BMD with a correlation of .846. Low weight and BMI predict osteoporosis and are associated with increased risks in postmenopausal women. The negative impact of low body weight on bone health should be more widely recognized.

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