Association between fasting blood glucose and intracranial cerebral artery stenosis: a secondary analysis based on a retrospective cross-sectional study in Korean adults

Author(s):  
Dan Wu ◽  
Danghan Xu ◽  
Fan Ye ◽  
Nuo Xu ◽  
Taotao Yao ◽  
...  
2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Shadassa Ourshalimian ◽  
Abu Mohd Naser Titu ◽  
Tom Clasen ◽  
Mahbubur Rahman ◽  
Kazi Matin Ahmed ◽  
...  

2020 ◽  
Author(s):  
Kaijie Xu ◽  
Xueying Cui ◽  
Bian Wang ◽  
Qingya Tang ◽  
Jianfang Cai ◽  
...  

Abstract Background Appropriate diet is an important determinant of kidney health. However, the association between vegetarian diets and renal function is unclear. Object We aimed to study the association between vegetarian diets and renal function in healthy adults. Design A total of 269 vegetarians (aged 34.5±8.7 years) and 269 sex- and age-matched nonvegetarian omnivores were enrolled in this cross-sectional study. Basic characteristics as well as daily dietary intakes were assessed by face-to-face interviews. Blood samples were collected, and renal function was assessed by measuring blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA) and estimated glomerular filtration rate (eGFR). Blood pressure, fasting blood glucose and blood lipid profiles were also assessed. Results The average age of the vegetarians was 35.4±8.6 years, 82.2% of whom were female. We evaluated the association between vegetarian diets and renal function by using multivariate analysis. Compared with omnivores, vegetarians had lower BUN (β= -0.63, 95% CI: -0.88 to -0.38), SCr (β= -2.07, 95% CI: -4.21 to -0.061), UA (β= -15.17, 95% CI: -27.81 to -2.53) and higher eGFR levels (β= 4.09, 95% CI: 0.23 to 7.96) after adjusting for sex, age, BMI, physical activity, alcohol consumption, smoking status, LDL, HDL, systolic pressure and fasting blood glucose. Further analysis of food composition and renal function showed that dietary fiber intake was significantly negatively associated with BUN [β= -0.02, 95% CI:(-0.03, 0.00)], SCr [β= -0.14, 95% CI:(-0.25, 0.04)], and UA [β= -0.72, 95% CI:(-1.36, 0.07)] and positively associated with eGFR [β= 0.20, 95% CI:(0.00, 0.40)]. Conclusions Healthy adult vegetarians have better renal function than omnivores, and the higher dietary fiber intake associated with vegetarian diets may contribute to the protective effect on renal function.


2019 ◽  
Vol 172 ◽  
pp. 249-257 ◽  
Author(s):  
Shadassa Ourshalimian ◽  
Abu Mohd Naser ◽  
Mahbubur Rahman ◽  
Solaiman Doza ◽  
Jennifer Stowell ◽  
...  

2020 ◽  
Vol 20 (2) ◽  
pp. 426-434
Author(s):  
Ayla Cagliyan Turk ◽  
SEVİL OKAN ◽  
SUMRU OZEL ◽  
Ahmet Musmul ◽  
Murat Baglicakoglu ◽  
...  

Introduction: Nigella Sativa is widely used traditional medicinal plant throughout the world as seeds and oil. It has been used to treat a wide range of disorders including Diabetes Mellitus (DM). Objective: Effect of oral Nigella Sativa on fasting blood glucose in non-diabetic individuals. Methods: A cross sectional study was conducted on 10 healthy non diabetic volunteers aged 20-35 years with normal fasting blood glucose (FBG). Subjects were given Nigella Sativa seeds orally (4gm) twice per day for 2 days. FBG was measured before and after Nigella Sativa supplementation by glucose oxidase methods using bio system A25. Results: The level of the fasting blood glucose was 99.4±3.1 mg/dl in the first day and deceased to 93.1±4.6 mg/dl after Nigella Sativa administration, which was statistically significant (p. value= 0.031). Conclusion: Nigella Sativa significantly reduced the level of blood glucose among non-diabetics adults. The mechanism of action of Nigella sativa needs to be investigated.


2020 ◽  
Vol 29 (6) ◽  
pp. 565-571
Author(s):  
Ju Young Lee ◽  
Sae Rom Lee ◽  
Sang Yeoup Lee

<b><i>Objectives:</i></b> To investigate the prevalence of asymptomatic coronary artery stenosis (CAS) using coronary computed tomography angiography (CCTA) in Korean men with erectile dysfunction (ED). <b><i>Subjects and Methods:</i></b> A cross-sectional study was conducted on 108 men who underwent CCTA at a health promotion center in Pusan National University Yangsan Hospital. Each subject who was evaluated for ED using the International Index of Erectile Dysfunction (IIEF) questionnaire did not have a past history or symptoms of coronary artery disease (CAD). We assessed the association between ED and CCTA-based CAS. <b><i>Results:</i></b> The overall prevalence of ED was 57.4%; furthermore, age (<i>p</i> = 0.001) and fasting blood glucose (<i>p =</i>0.035) were the metabolic risk factors that were most significantly associated with the presence of ED. The overall frequency of CAS was 31.5%, and ED (<i>p</i> = 0.022), age (<i>p</i> &#x3c; 0.001), fasting blood glucose (<i>p</i> = 0.021), and total cholesterol/high-density lipoprotein cholesterol (<i>p</i> = 0.029) were significantly associated with the presence of CAS. The prevalence of CAS was 40.3 and 19.6% in the ED and non-ED groups, respectively. Men with ED were 2.778 times more likely to present with CAS than those without ED (OR 2.778, 95% CI 1.143–6.749, <i>p</i> = 0.024); however multivariate logistic regression analysis, while controlling for age, total cholesterol/high-density lipoprotein cholesterol, and fasting blood glucose, suggested the absence of a significant association between ED and CCTA-based CAS. <b><i>Conclusion:</i></b> This study shows that CCTA-based CAS is a common phenomenon in men who have ED. Furthermore, ED patients without cardiac symptoms need to be investigated for the possibility of hidden CAD.


BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038046 ◽  
Author(s):  
Lucky Aziza Bawazier ◽  
Mochammad Sja'bani ◽  
Fredie Irijanto ◽  
Zulaela Zulaela ◽  
Agus Widiatmoko ◽  
...  

ObjectiveTo observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007.DesignCross-sectional study.SettingMlati Subdistrict, Sleman District, Yogyakarta Province, Indonesia.ParticipantsA total of 733 patients from ‘Mlati Study Database’ in 2007 were selected by simple random sampling using statistical software. Subjects had both physical and laboratory examinations.Outcome measuresMorning home BP and laboratory examination of urine (uric acid excretion and creatinine) and blood samples (SUA, blood urea nitrogen, creatinine, a lipid profile and fasting blood glucose levels).ResultsAbout 31.1% of 733 subjects with prehypertension became hypertensive after 10 years, 24.6% returned to normal tension and the rest of it remained in prehypertensive state. Mean (SD) of SUA levels in 2017 was significantly higher in men than in women (5.78 (1.25) mg/dL vs 4.52 (1.10) mg/dL, p<0.001). Furthermore, men tended to have high-normal (5–7 mg/dL) or high SUA levels (≥7 mg/dL) compared with women (p<0.001, Relative Risk (RR)=2.60). High-normal and high SUA levels in population with a history of prehypertension were significantly associated with current prehypertension and hypertension only in women (p=0.001, RR=1.21). Age and body mass index was found to be significantly associated with both systolic and diastolic BP in men, but only with systolic BP in women. Fasting blood glucose and SUA levels were significantly associated with systolic and diastolic BP only in women.ConclusionWe concluded that after 10 years, of 733 subjects with prehypertension, 31.1% became hypertensive. The SUA levels in men are significantly higher than those in women. Moreover, high-normal and high SUA levels were significantly associated with prehypertension and hypertension in women but not in men.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liang Gao ◽  
Yaju Zhang ◽  
Xingmin Wang ◽  
Hongli Dong

Abstract Background Apolipoprotein (Apo) may be associated with type 2 diabetes (T2D), however, little is known whether or not serum apolipoproteins are correlated with fasting blood glucose (FBG) and the prevalence of T2D in Chinese populations. In this study, we examined the association of serum ApoA1, ApoB, and the ratio of ApoB/ApoA1 (ApoB/A1 ratio) with T2D and FBG level, and compared apolipoprotein indicators in predicting T2D in Chinese adults. Methods A total of 1027 subjects were enrolled in this cross-sectional study. The association of ApoA1, ApoB, and ApoB/A1 ratio with T2D prevalence was determined using logistic regression models. Multivariate-analysis of covariance (ANCOVA) was performed for comparisons of the mean difference in FBG level. Results We found that ApoB and ApoB/A1 ratio were positively associated with T2D prevalence and FBG, while inverse association was noted between ApoA1 and T2D prevalence as well as FBG. Stratified analyses for sex, age, body mass index (BMI), smoking, and alcohol consumption showed no significant difference for the association of ApoA1, ApoB, and ApoB/A1 ratio with the prevalence of T2D among subgroups (all p-interactions> 0.05). Nonetheless, ApoA1 poorly performed in predicting T2D as it provided an AUC value of 0.310 that was significantly lower than those observed for ApoB (AUC value: 0.631) and ApoB/A1 ratio (AUC value: 0.685). Finally, path analyses indicated that the association between ApoB and T2D was mediated by BMI. Conclusions This study reveals the association of serum ApoA1, ApoB, and ApoB/A1 ratio with T2D and FBG in Chinese adults, suggesting that ApoB and ApoB/A1 ratio may be early indicators for predicting T2D. Prospective investigation in large cohort is needed.


Sign in / Sign up

Export Citation Format

Share Document