scholarly journals Methodological utility of chemerin as a novel biomarker of immunity and metabolism

2017 ◽  
Vol 6 (5) ◽  
pp. 340-347 ◽  
Author(s):  
Fabian Eichelmann ◽  
Cornelia Weikert ◽  
Romina di Giuseppe ◽  
Ronald Biemann ◽  
Berend Isermann ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Disease ◽  
Fatty Acid Binding Protein ◽  
Disease Risk ◽  
C Reactive Protein ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Chronic Disease Risk ◽  
Acid Binding Protein

Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses. Intra-individual reproducibility of chemerin measurements was assessed by calculating intraclass correlation coefficients (ICCs) and exploration of Bland–Altman plots. Reliability analyses revealed good reproducibility of chemerin measurements (ICC: 0.72 (95%-CI 0.65, 0.78)). Visual inspection of Bland–Altman plots confirmed that the two time point measurements had a high level of agreement. In correlation analyses, chemerin was positively correlated with adiposity measures (body mass index and waist circumference). In addition, independent of adiposity measures, chemerin was correlated with the biomarkers C-reactive protein, fatty acid-binding protein 4 and progranulin (Rho-s ranging from 0.23 to 0.37). In multivariable linear regression analysis, a combination of correlated factors including body mass index, waist circumference, C-reactive protein, progranulin and fatty acid-binding protein-4 explained 28.0% of chemerin concentrations. These findings demonstrate methodological utility of chemerin concentrations in population-based research setting. Human studies are highly warranted in order to provide further insights into the role of chemerin as a biomarker linking immunity and metabolism in relation to chronic disease risk.

Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

2011 ◽  
Vol 44 (4) ◽  
pp. 304-306 ◽  
Author(s):  
Anna Stefanska ◽  
Grazyna Sypniewska ◽  
Beata Blaszkiewicz ◽  
Irena Ponikowska ◽  
Malgorzata Cwiklinska-Jurkowska
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Acid Binding Protein

scholarly journals ADIPOCYTE FATTY ACID BINDING PROTEIN AND C-REACTIVE PROTEIN LEVELS AS INDICATORS OF INSULIN RESISTANCE DEVELOPMENT

2011 ◽  
Vol 155 (4) ◽  
pp. 355-359 ◽  
Author(s):  
Dagmar Horakova ◽  
Dalibor Pastucha ◽  
David Stejskal ◽  
Helena Kollarova ◽  
Katerina Azeem ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
C Reactive Protein ◽  
Resistance Development ◽  
Fatty Acid Binding ◽  
Protein Levels ◽  
Reactive Protein ◽  
Acid Binding Protein

ChemInform Abstract: Role of Heart-Type Fatty Acid Binding Protein in the Brain Function

ChemInform ◽  
2009 ◽  
Vol 40 (26) ◽  
Author(s):  
Keiju Motohashi ◽  
Yui Yamamoto ◽  
Norifumi Shioda ◽  
Hisatake Kondo ◽  
Yuji Owada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Brain Function ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
The Brain

scholarly journals Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes

2018 ◽  
Vol 64 (10) ◽  
pp. 1496-1504 ◽  
Author(s):  
Chi Ho Lee ◽  
Chloe Y Y Cheung ◽  
Yu Cho Woo ◽  
David T W Lui ◽  
Michele M A Yuen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Independent Predictor ◽  
Fatty Acid Binding ◽  
Men And Women ◽  
Acid Binding Protein ◽  
All Cause Mortality

AbstractINTRODUCTIONRaised circulating adipocyte fatty acid–binding protein (AFABP) concentrations are associated with various adverse health conditions. However, their relationship with mortality remains to be defined, especially in view of the sexual dimorphism of circulating AFABP concentrations. Here we investigated prospectively whether serum AFABP concentrations predict multiple mortality outcomes in men and women alike, using a large clinic-based cohort of individuals with type 2 diabetes, a condition with raised AFABP concentrations.METHODSBaseline serum AFABP concentrations were measured in 5305 research participants with a monoclonal antibody-based sandwich immunoassay. The role of circulating AFABP concentrations in predicting mortality outcomes was evaluated by multivariable Cox regression analysis.RESULTSAmong the 5305 participants (59% men) in this study, over a median follow-up of 5 years, there were 512 deaths (19.3 deaths per 1000 person-years). Circulating AFABP concentrations, with higher levels in women at baseline, predicted all-cause mortality (P < 0.001), cardiovascular mortality (P = 0.037), and infection-related deaths (P < 0.002) among all participants. In sex-specific analyses, circulating AFABP concentration was an independent predictor of all-cause mortality in both men and women and a predictor of cancer-related deaths and infection-related deaths in men only. Furthermore, the addition of serum AFABP concentrations improved the time-dependent c statistics in predicting all-cause mortality in participants with type 2 diabetes (P = 0.008).CONCLUSIONSCirculating AFABP concentration was an independent predictor of various mortality outcomes in type 2 diabetes over and above known risk factors of reduced survival in men and women. The role of AFABP as a prognostic biomarker and therapeutic target warrants further investigation.

scholarly journals Sleep and inflammation in resilient aging

2014 ◽  
Vol 4 (5) ◽  
pp. 20140009 ◽  
Author(s):  
Michael R. Irwin
Keyword(s):  
Chronic Disease ◽  
Sleep Quality ◽  
Health Outcomes ◽  
Physical Health ◽  
Disease Risk ◽  
Biological Pathway ◽  
Chronic Disease Risk ◽  
Physical Health Outcomes ◽  
Mental And Physical Health

Sleep quality is important to health, and increasingly viewed as critical in promoting successful, resilient aging. In this review, the interplay between sleep and mental and physical health is considered with a focus on the role of inflammation as a biological pathway that translates the effects of sleep on risk of depression, pain and chronic disease risk in aging. Given that sleep regulates inflammatory biologic mechanisms with effects on mental and physical health outcomes, the potential of interventions that target sleep to reduce inflammation and promote health in aging is also discussed.

Sign in / Sign up

Export Citation Format

Share Document