Captopril potentiates the anticonvulsant activity of carbamazepine and lamotrigine in the mouse maximal electroshock seizure model

2010 ◽  
Vol 117 (10) ◽  
pp. 1161-1166 ◽  
Author(s):  
Krzysztof Łukawski ◽  
Tomasz Jakubus ◽  
Grzegorz Raszewski ◽  
Stanisław J. Czuczwar
Keyword(s):  
Anticonvulsant Activity ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Seizure Model

Influence of ethacrynic acid on the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock seizure model

2010 ◽  
Vol 62 (5) ◽  
pp. 808-813 ◽  
Author(s):  
Krzysztof Łukawski ◽  
Grażyna Świderska ◽  
Jarogniew J. Łuszczki ◽  
Stanisław J. Czuczwar
Keyword(s):  
Antiepileptic Drugs ◽  
Anticonvulsant Activity ◽  
Ethacrynic Acid ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Seizure Model

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

2009 ◽  
Vol 64 (1-2) ◽  
pp. 1-5 ◽  
Author(s):  
Damião P. de Sousa ◽  
Franklin F. F. Nóbrega ◽  
Liana C. S. L. de Morais ◽  
Reinaldo N. de Almeida
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Animal Models ◽  
Motor Activity ◽  
Anticonvulsant Activity ◽  
Maximal Electroshock ◽  
Aromatic Plants ◽  
Depressant Effect ◽  
Maximal Electroshock Seizure ◽  
The Central Nervous System

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg/kg) produced a significant dosedependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4- ol at doses of 100, 200 and 300 mg/kg significantly increased the latency of pentylenetetrazole -induced convulsions. Terpinen-4-ol (200 and 300 mg/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and significant anticonvulsant activity.

scholarly journals Evaluation of Anticonvulsant and Antioxidant Activity of Senna occidentalis Seeds Extracts

2019 ◽  
Vol 9 (2) ◽  
pp. 183-187
Author(s):  
Vijay Vikram Singh ◽  
Jainendra Jain ◽  
Arun Kumar Mishra
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Anticonvulsant Activity ◽  
Future Research ◽  
Maximal Electroshock ◽  
Formulation Development ◽  
Dpph Method ◽  
Dose Dependent Fashion ◽  
Seizure Model ◽  
Dose Dependent

Aim: The aim of present work was to determine the anticonvulsant and antioxidant activity of Senna occidentalis L. ethanolic seed extract by different mod­els. Methods: For evaluation of anticonvulsant activity, Pentylenetetrazole (PTZ) seizure model and Maximal electroshock (MES) seizure model were used. For antioxidant activity, (1, 1-diphenyl - 2-picryl hydrazine (DPPH) and hydrogen peroxide (H2O2) method were used. Results: The finding suggested that the ethanolic extract (EAE) of Senna occidentalis in the dose 400 mg/kg body weight posses potent anticonvulsant activity. The EAE showed anticonvulsant action in dose dependent fashion. It was observed that upon increasing the concentration of extract, it showed reduced absorbance and increased free radical inhibition, and when comparison was made with Ascorbic acid, it showed marked antioxidant property in DPPH as well as H2O2 method. The IC50 of Ascorbic acid and EAE by DPPH method were found to be 14.56 and 14.8 respectively whereas the IC50 of Ascorbic acid and EAE by H2O2 method were found that 14.3and 14.8 respectively. Conclusion: The results of the present study concluded hat the EAE of Senna occidentalis L. possesses significant antioxidant and anticonvulsant activity. The activity was in dose dependent fashion. This study will assist in future research associated with formulation development of seeds of Senna occidentalis L. Keyword: Senna occidentalis L., Anticonvulsant, Antioxidant, DPPH model

Osthole suppresses seizures in the mouse maximal electroshock seizure model

2009 ◽  
Vol 607 (1-3) ◽  
pp. 107-109 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Marta Andres-Mach ◽  
Wojciech Cisowski ◽  
Irena Mazol ◽  
Kazimierz Glowniak ◽  
...  
Keyword(s):  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Seizure Model

Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model—an isobolographic analysis

2005 ◽  
Vol 515 (1-3) ◽  
pp. 54-61 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Marta M. Andres ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Synergistic Interaction ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Isobolographic Analysis ◽  
Seizure Model

1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model

2006 ◽  
Vol 50 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Lucyna Antkiewicz-Michaluk ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Anticonvulsant Action ◽  
Seizure Model

scholarly journals Pharmacodynamic and Pharmacokinetic Interaction Studies of Loreclezole with Felbamate, Lamotrigine, Topiramate, and Oxcarbazepine in the Mouse Maximal Electroshock Seizure Model

Epilepsia ◽  
2005 ◽  
Vol 46 (3) ◽  
pp. 344-355 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Neville Ratnaraj ◽  
Philip N. Patsalos ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Pharmacokinetic Interaction ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Interaction Studies ◽  
Seizure Model

scholarly journals STUDY OF THE ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF ACORUS CALAMUS IN ALBINO RATS

2019 ◽  
Vol 12 (1) ◽  
pp. 185
Author(s):  
Shipra Kaushik ◽  
Kalpana Gohain
Keyword(s):  
Normal Saline ◽  
Anticonvulsant Activity ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Acorus Calamus ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Onset Of Action ◽  
Electrical Shock ◽  
Seizure Models

Objective: Root of Acorus calamus has been traditionally used as an anticonvulsant. The aim of the study is to assess the anticonvulsant activity of ethanolic extract of A. calamus (EEAC) by maximal electroshock seizure (MES) and pentylenetetrazol (PTZ)-induced seizure models on albino (Wistar strain) rats.Methods: Albino rats were taken and divided into five groups, each consisting of five rats both for MES and PTZ model. One group was used as control (normal saline 10 ml/kg), one as standard (phenytoin in MES model/diazepam in PTZ model), and three groups for the test drug (EEAC in the doses of 100, 200, and 400 mg/kg). In MES model, maximal electrical shock of 150 mA was passed for 0.2 s through earlobe electrodes after 30 min of giving the drugs and normal saline. Different stages of convulsions were noted down along with time spent by the animal in each phase of convulsions. In PTZ model, PTZ was injected 30 min after giving the drugs and normal saline, and onset of action and severity of convulsions were noted. Data were statistically analyzed by one-way analysis of variance followed by multiple Dunnett’s test.Results: EEAC dose dependently reduced the duration of tonic hind limb extension in MES model, and there was increase in latency and occurrence of convulsions in PTZ model.Conclusion: EEAC has anticonvulsant activity.

scholarly journals To evaluate the anticonvulsant activity of ethanolic extract of Moringa oleifera (drumstick leaves) in albino mice

2017 ◽  
Vol 6 (10) ◽  
pp. 2491
Author(s):  
Sushma V. Naidu ◽  
Harsha R. ◽  
Jyothsnya S.
Keyword(s):  
Anticonvulsant Activity ◽  
Hind Limb ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
P Value ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Isolation And Identification ◽  
Standard Drug ◽  
Albino Mice

Background: To evaluate the anti-convulsant activity of ethanolic extract of Moringa oleifera (Drum stick leaves) in seizure induced albino mice and to compare it with standard drug Sodium valproate.Methods: Swiss albino mice of either sex weighing around 25-30g were randomly selected and divided into four groups of six mice each. Group 1: control- treated with gum acacia. Group 2: Standard - Valproic acid 40mg/kg body weight. Group 3: T1- ethanolic extract of Moringa oleifera (150mg/kg). Group 4: T2 - ethanolic extract of Moringa oleifera (300mg/kg). All drugs were administered orally one hour prior to induction of seizure. The anticonvulsant activity was screened using maximal electroshock seizure (MES) model and pentylenetetrazole (PTZ) model.Results: Results were analysed by ANOVA followed by Bonferroni’s post hoc test. Abolition of Tonic hind limb extension was taken as the protective end point against MES induced seizures and prolongation of seizure latency in PTZ model.At both the doses the ethanolic extract of Moringa oleifera significantly (p value <0.05) reduced the duration of hind limb extension in MES test and also significantly (p value <0.05) delayed the onset of clonic seizures in PTZ induced convulsion when compared with control group.Conclusions: On comparing the percentage protection offered by Moringa oleifera leaves against both MES and PTZ model, it possesses significant anticonvulsant activity at both doses, with more efficacy at 300mg/kg BW indicating that the test drug can prove a very promising drug for treatment of epilepsy. Further studies are required for isolation and identification of the active constituent.

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