Potential role of high mobility group box protein 1 and intermittent PTH (1–34) in periodontal tissue repair following orthodontic tooth movement in rats

2012 ◽  
Vol 17 (3) ◽  
pp. 989-997 ◽  
Author(s):  
M. Wolf ◽  
S. Lossdörfer ◽  
N. Abuduwali ◽  
A. Jäger
Keyword(s):  
Tissue Repair ◽  
Potential Role ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
High Mobility ◽  
High Mobility Group ◽  
Periodontal Tissue ◽  
Intermittent Pth

scholarly journals Anabolic Properties of High Mobility Group Box Protein-1 in Human Periodontal Ligament CellsIn Vitro

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Michael Wolf ◽  
Stefan Lossdörfer ◽  
Piero Römer ◽  
Rogerio Bastos Craveiro ◽  
James Deschner ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Tooth Movement ◽  
Therapeutic Potential ◽  
Marker Gene ◽  
Orthodontic Tooth Movement ◽  
High Mobility ◽  
High Mobility Group ◽  
Nodule Formation ◽  
Hmgb1 Protein ◽  
Pdl Cells

High mobility group box protein-1 (HMGB1) is mainly recognized as a chemoattractant for macrophages in the initial phase of host response to pathogenic stimuli. However, recent findings provide evidence for anabolic properties in terms of enhanced proliferation, migration, and support of wound healing capacity of mesenchymal cells suggesting a dual role of the cytokine in the regulation of immune response and subsequent regenerative processes. Here, we examined potential anabolic effects of HMGB1 on human periodontal ligament (PDL) cells in the regulation of periodontal remodelling, for example, during orthodontic tooth movement. Preconfluent human PDL cells (hPDL) were exposed to HMGB1 protein and the influence on proliferation, migration, osteogenic differentiation, and biomineralization was determined by MTS assay, real time PCR, immunofluorescence cytochemistry, ELISA, and von Kossa staining. HMGB1 protein increased hPDL cell proliferation, migration, osteoblastic marker gene expression, and protein production as well as mineralized nodule formation significantly. The present findings support the dual character of HMGB1 with anabolic therapeutic potential that might support the reestablishment of the structural and functional integrity of the periodontium following periodontal trauma such as orthodontic tooth movement.

A potential role of high mobility group box-1 (HGMB1) in inflammatory vascular remodelling

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
H Xu ◽  
D Zabini ◽  
A Olschewski ◽  
G Kwapiszewska ◽  
LM Marsh
Keyword(s):  
Potential Role ◽  
High Mobility ◽  
High Mobility Group ◽  
Vascular Remodelling

scholarly journals Potential role of high-mobility group box 1 protein in the pathogenesis of influenza H5N1 virus infection

2014 ◽  
Vol 58 (01) ◽  
pp. 69-75 ◽  
Author(s):  
X. Q. HOU ◽  
J. L. QIN ◽  
X. X. ZHENG ◽  
L. WANG ◽  
S. T. YANG ◽  
...  
Keyword(s):  
Virus Infection ◽  
H5n1 Virus ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group ◽  
Influenza H5n1

scholarly journals Potential Role of High Mobility Group Box 1 in Viral Infectious Diseases

2006 ◽  
Vol 19 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Haichao Wang ◽  
Mary F. Ward ◽  
Xue-Gong Fan ◽  
Andrew E. Sama ◽  
Wei Li
Keyword(s):  
Infectious Diseases ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

2008 ◽  
Vol 178 (8) ◽  
pp. 822-831 ◽  
Author(s):  
Steven M. Rowe ◽  
Patricia L. Jackson ◽  
Gang Liu ◽  
Mathew Hardison ◽  
Alessandra Livraghi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Potential Role ◽  
High Mobility ◽  
Airway Disease ◽  
High Mobility Group ◽  
Cystic Fibrosis Airway

scholarly journals TOX as a potential target for immunotherapy in lymphocytic malignancies

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chaofeng Liang ◽  
Shuxin Huang ◽  
Yujie Zhao ◽  
Shaohua Chen ◽  
Yangqiu Li
Keyword(s):  
T Cell ◽  
Potential Role ◽  
Hematological Malignancies ◽  
High Mobility ◽  
High Mobility Group ◽  
Biological Functions ◽  
Hmg Box ◽  
Cell Exhaustion ◽  
Potential Target

AbstractTOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.

scholarly journals Localization of osteopontin and osterix in periodontal tissue during orthodontic tooth movement in rats

2011 ◽  
Vol 82 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Ji-Youn Kim ◽  
Byung-In Kim ◽  
Seong-Suk Jue ◽  
Jae Hyun Park ◽  
Je-Won Shin
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Nickel Titanium ◽  
Nuclear Antigen ◽  
Periodontal Tissue ◽  
Histological Changes ◽  
Proliferating Cell ◽  
Periodontal Tissue Remodeling

Abstract Objective: To evaluate the localization of osteopontin (OPN) and osterix in periodontal tissue during experimental tooth movement with heavy force in rats. Materials and Methods: Nickel-titanium closed-coil springs were used to create a 100 g mesial force to the maxillary first molars. On days 3, 7, 10, and 14 after force application, histological changes in periodontium were examined by immunohistochemistry using proliferating cell nuclear antigen (PCNA), OPN, and osterix. Results: PCNA-positive cells were found close to the alveolar bone and cementum on both sides. OPN-positive cells were observed along the cementing line of the cementum and bone on both sides and also were visible along with newly formed fibers in the periodontal ligament on the tension side. Osterix-positive cells were strongly detected on the surface of the alveolar bone and cementum on both sides. Conclusions: During tooth movement, periodontal remodeling occurs on both sides. These results indicate that OPN and osterix may play an important role of differentiation and osteoblasts and cementoblasts matrix formation during periodontal tissue remodeling.

scholarly journals Potential role of High mobility group box 1 in hepatocellular carcinoma

2014 ◽  
Vol 8 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Rong-Rong Zhou ◽  
Xu-Yuan Kuang ◽  
Yan Huang ◽  
Ning Li ◽  
Ming-Xiang Zou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group
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