scholarly journals Potential role of High mobility group box 1 in hepatocellular carcinoma

2014 ◽  
Vol 8 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Rong-Rong Zhou ◽  
Xu-Yuan Kuang ◽  
Yan Huang ◽  
Ning Li ◽  
Ming-Xiang Zou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group

A potential role of high mobility group box-1 (HGMB1) in inflammatory vascular remodelling

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
H Xu ◽  
D Zabini ◽  
A Olschewski ◽  
G Kwapiszewska ◽  
LM Marsh
Keyword(s):  
Potential Role ◽  
High Mobility ◽  
High Mobility Group ◽  
Vascular Remodelling

Role of High Mobility Group Box1 in Pathogenesis of Hepatitis C Virus induced Hepatocellular Carcinoma

2020 ◽  
Vol EJMM29 (4) ◽  
pp. 135-141
Author(s):  
Nouran E. Samra ◽  
Shahira El-Etreby ◽  
Rasha H. El-Mahdy ◽  
Samah S. El-Kazzaz ◽  
Nariman M. El-Nashar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Nuclear Dna ◽  
Inflammatory Responses ◽  
High Mobility ◽  
Dna Binding Protein ◽  
High Mobility Group ◽  
Over Expression ◽  
Different Types

Hepatocellular carcinoma "HCC" is a leading cause of cancer mortality worldwide. High-mobility group box 1 "HMGB1" is a nuclear DNA-binding protein which involved in DNA stability, programmed cell death, immune response and inflammatory responses in HCV and HCC. Its over expression was revealed in HCC and different types of human cancers.

scholarly journals Potential role of high-mobility group box 1 protein in the pathogenesis of influenza H5N1 virus infection

2014 ◽  
Vol 58 (01) ◽  
pp. 69-75 ◽  
Author(s):  
X. Q. HOU ◽  
J. L. QIN ◽  
X. X. ZHENG ◽  
L. WANG ◽  
S. T. YANG ◽  
...  
Keyword(s):  
Virus Infection ◽  
H5n1 Virus ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group ◽  
Influenza H5n1

scholarly journals Potential Role of High Mobility Group Box 1 in Viral Infectious Diseases

2006 ◽  
Vol 19 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Haichao Wang ◽  
Mary F. Ward ◽  
Xue-Gong Fan ◽  
Andrew E. Sama ◽  
Wei Li
Keyword(s):  
Infectious Diseases ◽  
Potential Role ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

2008 ◽  
Vol 178 (8) ◽  
pp. 822-831 ◽  
Author(s):  
Steven M. Rowe ◽  
Patricia L. Jackson ◽  
Gang Liu ◽  
Mathew Hardison ◽  
Alessandra Livraghi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Potential Role ◽  
High Mobility ◽  
Airway Disease ◽  
High Mobility Group ◽  
Cystic Fibrosis Airway

scholarly journals TOX as a potential target for immunotherapy in lymphocytic malignancies

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chaofeng Liang ◽  
Shuxin Huang ◽  
Yujie Zhao ◽  
Shaohua Chen ◽  
Yangqiu Li
Keyword(s):  
T Cell ◽  
Potential Role ◽  
Hematological Malignancies ◽  
High Mobility ◽  
High Mobility Group ◽  
Biological Functions ◽  
Hmg Box ◽  
Cell Exhaustion ◽  
Potential Target

AbstractTOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.

High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics

2019 ◽  
Vol 20 (14) ◽  
pp. 1474-1485 ◽  
Author(s):  
Eyaldeva C. Vijayakumar ◽  
Lokesh Kumar Bhatt ◽  
Kedar S. Prabhavalkar
Keyword(s):  
Myocardial Infarction ◽  
Vagus Nerve Stimulation ◽  
Nuclear Protein ◽  
Therapeutic Potential ◽  
High Mobility ◽  
Dna Binding Protein ◽  
High Mobility Group ◽  
Eukaryotic Cells ◽  
Hmgb1 Protein

High mobility group box-1 (HMGB1) mainly belongs to the non-histone DNA-binding protein. It has been studied as a nuclear protein that is present in eukaryotic cells. From the HMG family, HMGB1 protein has been focused particularly for its pivotal role in several pathologies. HMGB-1 is considered as an essential facilitator in diseases such as sepsis, collagen disease, atherosclerosis, cancers, arthritis, acute lung injury, epilepsy, myocardial infarction, and local and systemic inflammation. Modulation of HMGB1 levels in the human body provides a way in the management of these diseases. Various strategies, such as HMGB1-receptor antagonists, inhibitors of its signalling pathway, antibodies, RNA inhibitors, vagus nerve stimulation etc. have been used to inhibit expression, release or activity of HMGB1. This review encompasses the role of HMGB1 in various pathologies and discusses its therapeutic potential in these pathologies.

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