Cardiac manifestations in primary antiphospholipid syndrome and their association to antiphospholipid antibodies’ types and titers—cross-sectional study of Serbian cohort

2022 ◽  
Author(s):  
Aleksandra Djokovic ◽  
Ljudmila Stojanovich ◽  
Natasa Stanisavljevic ◽  
Sandra Djokic ◽  
Branka Filipovic ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Cross Sectional Study ◽  
Primary Antiphospholipid Syndrome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cardiac Manifestations

Coagulation Activation and Fibrinolytic imbalance in Subjects with Idiopathic Antiphospholipid Antibodies -A Crucial Role for Acquired Free Protein S Deficiency

1996 ◽  
Vol 76 (02) ◽  
pp. 190-194 ◽  
Author(s):  
Paul R J Ames ◽  
Catello Tommasino ◽  
Luigi Iannaccone ◽  
Massimo Brillante ◽  
Renato Cimino ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Thrombin Generation ◽  
Protein S ◽  
Venous Occlusion ◽  
Cross Sectional Study ◽  
Primary Antiphospholipid Syndrome ◽  
Cross Sectional ◽  
Free Protein ◽  
Asymptomatic Subjects

SummaryTo explore the coagulation/fibrinolytic balance and its relation with free protein S (f-PS) in subjects with antiphospholipid antibodies (aPLs) outside the setting of autoimmune inflammatory disorders, we carried out a cross-sectional study on 18 thrombotic patients with primary antiphospholipid syndrome and 18 apparently healthy subjects with persistence of idiopathic aPLs. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT) and D-Dimer (D-D) were taken as markers of thrombin generation and fibrin turnover. Mean F1+2 levels were higher in thrombotic (p = 0.006) and non-thrombotic subjects (p = 0.0001) than in controls as were those of D-D (p <0.0001 and p = 0.003 respectively). TAT levels did not differ. Lower mean levels of f-PS were found in thrombotic (p = 0.0006) and non-thrombotic subjects (p = 0.002) than in controls. Within both groups, mean Fl+2 levels were higher in subjects who had low f-PS levels compared to those with normal f-PS levels (p = 0.01). Gender analysed data revealed blunted tPA release (venous occlusion test) in thrombotic females (from 16.80 ± 0.79 to 21.3 ± 3.9 ng/nl, NS) but not in thrombotic males (from 18.2 ± 2.0 to 33.7 ± 4.9 ng/ml, p = 0.01) nor in asymptomatic subjects of either sex. Also, in both patient groups females had higher mean PAI than males (p <0.0002) and than control females (p <0.02). Low free protein S was found in 100% of non-thrombotic and in 90% of thrombotic patients with defective fibrinolysis. These data are consistent with increased thrombin generation, accelerated fibrin turnover and fibrinolysis abnormalities also in asymptomatic carriers of aPLs and highlight a central role for acquired f-PS deficiency in the thrombotic tendency of the antiphospholipid syndrome.

scholarly journals Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study

2021 ◽  
pp. 101070
Author(s):  
Laura A. Benjamin ◽  
Ross W. Paterson ◽  
Rachel Moll ◽  
Charis Pericleous ◽  
Rachel Brown ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Cross Sectional Study ◽  
Neurological Manifestations ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional

scholarly journals Antiphospholipid Antibodies in Vascular Surgery Patients A Cross-Sectional Study

1994 ◽  
Vol 220 (4) ◽  
pp. 544-551 ◽  
Author(s):  
Lloyd M. Taylor ◽  
Richard W. Chitwood ◽  
Ronald L. Dalman ◽  
Gary Sexton ◽  
Scott H. Goodnight ◽  
...  
Keyword(s):  
Vascular Surgery ◽  
Antiphospholipid Antibodies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Patients with Essential Thrombocythaemia have an Increased Prevalence of Antiphospholipid Antibodies which may be associated with Thrombosis

2002 ◽  
Vol 87 (05) ◽  
pp. 802-807 ◽  
Author(s):  
S. Donohoe ◽  
P. Carr ◽  
M. Dave ◽  
I. Mackie ◽  
S.J. Machin ◽  
...  
Keyword(s):  
Relative Risk ◽  
Antiphospholipid Antibodies ◽  
Significant Proportion ◽  
Cross Sectional Study ◽  
Essential Thrombocythaemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Thrombotic Risk ◽  
Glycoprotein I ◽  
Thrombotic Complications

SummaryA significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 200 “elderly” controls (> 50 years) there was a significant increase in anticardiolipin IgM (p < 0.0001) and anti β2 glycoprotein I (anti-β2GPI) IgM (p < 0.0001) antibodies in ET. Thrombosis occurred in 10/20 with APA and 12/48 without, p = 0.04, relative risk 2.0 (95% confidence intervals 1.03–3.86); these patients did not differ in terms of other clinical features. The prevalence of thrombosis in patients with dual APA (6/7) was significant when compared to those with single APA (p = 0.02) and the remaining patients (p < 0.0002). Also anti-β2GP1 IgM antibodies either alone, or in combination with another APA, were associated with thrombosis (p = 0.02). These results suggest that the prevalence of APA in ET and their influence upon thrombotic risk merit investigation in a larger study.

scholarly journals Cardiac manifestations of cocaine abuse: a cross-sectional study of asymptomatic men with a history of long-term abuse of “crack” cocaine

1992 ◽  
Vol 20 (5) ◽  
pp. 1168-1174 ◽  
Author(s):  
Simon Chakko ◽  
Aland Fernandez ◽  
Thomas A. Mellman ◽  
Fernando J. Milanes ◽  
Kenneth M. Kessler ◽  
...  
Keyword(s):  
Cocaine Abuse ◽  
Crack Cocaine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Cardiac Manifestations ◽  
Asymptomatic Men

scholarly journals CARDIAC MANIFESTATIONS IN DENGUE FEVER: A CROSS SECTIONAL STUDY FROM A TERTIARY CARE CENTRE OF NORTH INDIA

2019 ◽  
Vol 6 (17) ◽  
pp. 1300-1305
Author(s):  
Mansi Singh ◽  
Ajay Kumar ◽  
Sanjay Mehrotra ◽  
Virendra Atam ◽  
Ravi Mishra ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
North India ◽  
Care Centre ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Cardiac Manifestations
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