Chiasmal optic neuritis may be secondary to pneumococcal meningitis: a child with acute monocular vision loss

The optic nerve carries visual information from your eye to your brain. Optic neuritis is when your optic nerve becomes inflamed. Optic neuritis can flare up suddenly from an infection or nerve disease. The inflammation usually causes temporary vision loss that typically happens in only one eye. Those with Optic neuritis sometimes experience pain. As you recover and the inflammation goes away, your vision will likely return. There are no direct references in our classics regarding optic neuritis but can be contemplated as a condition by name Parimlayi Timira. The specific management as such is not cited but a transcendence approach can be done with adopting the treatment which has the ability to pacify the already occurred pathology and prevent the further development of the disease. One such interesting case study on Optic neuritis is elaborated here where in specific treatment modalities (Shodana, Shamana and Kriyakalpas) played role in pacifying the condition.

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Migrainous infarction of the eye: Two cases of monocular ischemic complications associated with retinal migraine

Cephalalgia ◽

10.1177/03331024211056286 ◽

2021 ◽

pp. 033310242110562

Author(s):

Nikita Chhabra ◽

Chia-Chun Chiang ◽

Marie A Di Nome ◽

Odette Houghton ◽

Rachel E Carlin ◽

...

Keyword(s):

Visual Loss ◽

Vision Loss ◽

Central Retinal Artery Occlusion ◽

Retinal Artery Occlusion ◽

Artery Occlusion ◽

Monocular Vision ◽

Ischemic Optic Neuropathy ◽

Migrainous Infarction ◽

Ischemic Complications ◽

History Of

Background Retinal migraine is defined by fully reversible monocular visual phenomena. We present two cases that were complicated by permanent monocular vision deficits. Cases A 57-year-old man with history of retinal migraine experienced persistent monocular vision loss after one stereotypical retinal migraine, progressing to finger-count vision over 4 days. He developed paracentral acute middle maculopathy that progressed to central retinal artery occlusion. A 27-year-old man with history of retinal migraine presented with persistent right eye superotemporal scotoma after a retinal migraine. Relative afferent pupillary defect and superotemporal visual field defect were noted, consistent with ischemic optic neuropathy. Conclusion Retinal migraine can complicate with permanent monocular visual loss, suggesting potential migrainous infarction of the retina or optic nerve. A thorough cerebrovascular evaluation must be completed, which was unrevealing in our cases. Acute and preventive migraine therapy may be considered in retinal migraine patients, to mitigate rare but potentially permanent visual loss.

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Association of MMP-2 (–1306 C/T) Gene Polymorphism with Predisposition to Optic Neuritis and Optic Neuritis Together with Multiple Sclerosis

Medicina ◽

10.3390/medicina54020029 ◽

2018 ◽

Vol 54 (2) ◽

pp. 29 ◽

Cited By ~ 2

Author(s):

Rasa Liutkevičienė ◽

Alvita Vilkevičiūtė ◽

Mantas Banevičus ◽

Raminta Miežytė ◽

Loresa Kriaučiūnienė

Keyword(s):

Multiple Sclerosis ◽

Gene Polymorphism ◽

Optic Neuritis ◽

Vision Loss ◽

Matrix Metalloproteinase 2 ◽

Control Group ◽

Autoimmune Inflammatory Disease ◽

Pcr Method ◽

Polymerase Chain ◽

The Relationship

Background and objective: Optic neuritis (ON) is characterized by painful, usually monocular vision loss with decreased visual acuity and defects of the visual field and color vision. The etiology and pathophysiology of ON is not completely clear. It is thought that a matrix metalloproteinase 2 (MMP-2) gene plays an essential role in this autoimmune inflammatory disease. The aim of this study was to determine the relationship between the MMP-2 (-1306 C/T) rs243865 gene polymorphism and ON, and that of ON with multiple sclerosis. Materials and methods: Patients with ON/ON and multiple sclerosis and a control group of healthy individuals were enrolled in this study. The genotyping test of the MMP-2 (-1306 C/T) was carried out using a real-time polymerase chain reaction (PCR) method. Results: Analysis revealed that T allele at the MMP-2 (-1306 C/T) was less frequent in the ON group compared to the control group (14.5% vs. 23.3%, p = 0.031), and was associated with decreased likelihood of ON development (OR = 0.566; 95% CI: 0.333-0.962; p = 0.036). No significant associations were revealed while comparing the subgroups of ON patients with and without multiple sclerosis. Conclusion: The MMP-2 (-1306 C/T) gene polymorphism was found to be associated with ON development.

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A Woman With Subacute Painful Vision Loss

10.1093/med/9780197583425.003.0001 ◽

2021 ◽

pp. 3-6

Author(s):

Jiraporn Jitprapaikulsan ◽

M. Tariq Bhatti ◽

Eric R. Eggenberger ◽

Marie D. Acierno ◽

John J. Chen

Keyword(s):

Optic Neuritis ◽

Eye Movement ◽

Immunoglobulin G ◽

Vision Loss ◽

Visual Fields ◽

Corticosteroid Treatment ◽

Antineutrophil Cytoplasmic Antibody ◽

Myelin Oligodendrocyte Glycoprotein ◽

Intravenous Methylprednisolone ◽

Eye Pain

A 51-year-old White woman sought care for vision loss 1 week after a nonspecific upper respiratory tract infection. She reported pain in both eyes exacerbated by eye movement, which lasted for several days, followed by bilateral vision loss to the level of counting fingers–only vision. Optic neuritis was diagnosed, and she was treated with 1 g intravenous methylprednisolone for 3 days. Her vision improved substantially, and the pain resolved during the corticosteroid treatment. However, 1 week later, she woke up with right eye pain and vision loss. She was again treated with 5 days of intravenous methylprednisolone, with visual improvement nearly back to baseline. Two weeks later, she had recurrence of painful vision loss in both eyes. A diagnosis of chronic relapsing inflammatory optic neuropathy was made. Tests for serum angiotensin-converting enzyme, antineutrophil cytoplasmic antibody, antinuclear antibody, Lyme disease, syphilis, tuberculosis, and aquaporin-4-immunoglobulin G antibodies were negative. Serum was definitively positive for myelin oligodendrocyte glycoprotein-immunoglobulin G antibodies at a titer of 1:1,000. Myelin oligodendrocyte glycoprotein-immunoglobulin G–associated recurrent optic neuritis was diagnosed. After her diagnosis of recurrent corticosteroid-dependent optic neuritis associated with myelin oligodendrocyte glycoprotein-immunoglobulin G positivity, the patient was treated with 5 days of intravenous methylprednisolone. The eye pain resolved, and her vision returned to normal. At follow-up evaluation, the patient’s visual acuity, color vision, and visual fields were normal in both eyes, but there was mild bilateral optic disc pallor. She has not had recurrent demyelinating episodes while on chronic immunotherapy. Optic neuritis is an inflammatory demyelination of the optic nerve manifesting as acute to subacute vision loss, classically associated with pain with eye movement. The long-term prevention and prognosis depend on the cause of the optic neuritis.

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Compressive Optic Neuropathy

Neuro-Ophthalmology ◽

10.1093/med/9780195390841.003.0004 ◽

2011 ◽

pp. 21-24

Author(s):

Matthew J. Thurtell ◽

Robert L. Tomsak ◽

Robert B. Daroff

Keyword(s):

Optic Nerve ◽

Optic Neuropathy ◽

Vision Loss ◽

Clinical Signs ◽

Monocular Vision ◽

Compressive Optic Neuropathy ◽

Imaging Characteristics ◽

Optic Nerve Sheath Meningioma ◽

Common Causes ◽

Optic Nerve Compression

Optic nerve compression results in progressive, and often painless, monocular vision loss. In this chapter, we review the clinical signs and common causes of compressive optic neuropathy. We discuss in more detail the imaging characteristics and management of optic nerve sheath meningioma.

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Monocular Vision Loss: A Rare Cause

Clinical Practice and Cases in Emergency Medicine ◽

10.5811/cpcem.2019.6.43224 ◽

2019 ◽

Vol 3 (4) ◽

pp. 436-437

Author(s):

David Lane ◽

Kaila Pomeranz ◽

Shannon Findlay ◽

Daniel Miller

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Vision Loss ◽

Metastatic Breast ◽

Optic Chiasm ◽

Monocular Vision ◽

Resonance Imaging ◽

History Of ◽

Cerebral Structures ◽

Optic Nerve Compression

A 62-year-old woman with a history of metastatic breast cancer and known meningioma presented with unilateral vision loss associated with anisocoria and an afferent pupillary defect. On magnetic resonance imaging we found the cause to be optic nerve compression by a right frontal meningioma. Monocular vision-loss etiologies are anatomically localized to structures anterior to the optic chiasm. This case serves as a reminder that cerebral structures in this location must not be forgotten in the differential.

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A case report of unrecovered monocular vision loss after anterior clinoid mucocele resection

American Journal of Ophthalmology Case Reports ◽

10.1016/j.ajoc.2020.100980 ◽

2020 ◽

Vol 20 ◽

pp. 100980

Author(s):

Shizhong Zhang ◽

Zhen Li ◽

Hong Ye ◽

Han Zhao ◽

Qiong Wu ◽

...

Keyword(s):

Case Report ◽

Vision Loss ◽

Monocular Vision

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Proptosis, Orbital Pain, and Long-Standing Monocular Vision Loss Resolved by Surgical Resection of Intraosseous Spheno-Orbital Meningioma: A Case Report and Literature Review

Journal of Neurological Surgery Reports ◽

10.1055/s-0040-1708845 ◽

2020 ◽

Vol 81 (01) ◽

pp. e28-e32

Author(s):

Jonathan M. Parish ◽

Michael Shields ◽

Mackenzie Jones ◽

Scott D. Wait ◽

Vinay R. Deshmukh

Keyword(s):

Case Report ◽

Vision Loss ◽

Visual Fields ◽

Residual Tumor ◽

Monocular Vision ◽

Optic Canal ◽

Subtotal Resection ◽

Orbital Reconstruction ◽

Orbital Pain ◽

Orbital Meningioma

Abstract Background and Importance We present a case of a patient with a residual intraosseous sphenoid wing meningioma presenting with proptosis, orbital pain, and monocular vision loss for 8 months who underwent decompression of the optic canal, orbital contents, and orbital reconstruction resulting in significant improvement in her vision loss with full resolution of proptosis and orbital pain. Clinical Presentation A 43-year-old female presented with a 1 year history of headache, peri-orbital pain, proptosis, and severe vision loss. She had previously undergone subtotal resection of a large Simpson Grade 1 spheno-orbital meningioma 3 years prior at an outside institution. Workup at our institution revealed hyperostosis of the left greater wing of the sphenoid bone and narrowing of the optic canal along with bony enhancement concerning for residual tumor. The patient was given the recommendation from outside institutions for radiation, presumably due to the chronicity of her visual loss. Our institution recommended resection of the residual osseous tumor with orbital reconstruction. Less than 2 weeks after surgery, the patient noted significant improvement in orbital pain and vision. At 3 months, she had regained full and symmetric orbital appearance with no orbital pain. Her visual acuity improved to 20/30 with full visual fields. Conclusion Surgical decompression of the optic canal and orbital contents for tumor related sphenoid wing hyperostosis should be strongly considered, despite an extended duration of visual change and loss. This case report shows that vision can be significantly restored even after symptoms have been present for greater than 6 months.

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