scholarly journals Validation of the Composite Autonomic Symptom Score 31 in the German language

2021 ◽  
Author(s):  
Max-Josef Hilz ◽  
Ruihao Wang ◽  
Wolfgang Singer
Keyword(s):  
Symptom Score ◽  
Orthostatic Intolerance ◽  
Correlation Coefficients ◽  
German Version ◽  
Self Assessment ◽  
Autonomic Symptom ◽  
Autonomic Symptoms ◽  
Cronbach Alpha ◽  
And Gender ◽  
Post Hoc

Abstract Background The Composite Autonomic Symptom Score 31 (COMPASS 31) is a validated, 31-item self-assessment questionnaire assessing autonomic symptoms in six domains, orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor function. So far, there is no validated German COMPASS 31 version. This study aimed at developing and validating a German COMPASS 31. Methods Two autonomic experts with command of German and English independently translated the English COMPASS 31 into German. One agreed-upon German version was translated back into English to assure conformity with the original version. Twenty patients with possible autonomic symptoms and 20 age- and gender-matched healthy persons completed the English and German COMPASS 31 in a randomized order with a 4-week interval. To evaluate reliability of the German COMPASS 31, total scores and sub-scores of the domains assessed with the German version were correlated with corresponding scores of the English version using Pearson’s or Spearman’s test. The Cronbach alpha-coefficient evaluated the internal consistency of the questions. Total- and sub-scores of both COMPASS 31 versions were compared between patients and controls by analysis of variance with post-hoc analysis (significance: p < 0.05). Results Total scores and sub-scores of the German and English COMPASS 31 correlated significantly (p < 0.001) and closely (correlation coefficients: 0.757–0.934). Cronbach alpha-coefficients were above 0.7 in all domains except for the secretomotor domain. In the German and English COMPASS 31, total scores were significantly higher in patients than controls. Conclusions The German COMPASS 31 is reliable, internally consistent, and valid to detect and quantify autonomic symptoms in patients with neurological disorders.

scholarly journals Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results

2020 ◽  
Vol 17 (16) ◽  
pp. 5872
Author(s):  
Franca Dipaola ◽  
Caterina Barberi ◽  
Elena Castelnuovo ◽  
Maura Minonzio ◽  
Roberto Fornerone ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Repeated Measures ◽  
Time Course ◽  
Orthostatic Intolerance ◽  
Occupational Status ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Autonomic Symptoms ◽  
Post Hoc

Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of chronically reducing the quality of life and the work ability of patients. The study aim was to assess the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients’ clinical profiles were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31) and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett’s post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden of autonomic symptoms was high (overall COMPASS 31 = 49.9 ± 14.3 /100). Main complaints were related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement in pupillomotor function and overall score was detected by the COMPASS 31. These findings were confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed by VAS. However, these improvements did not change patients’ occupational status. Awareness of POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients’ condition.

scholarly journals Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

2021 ◽  
Vol 12 ◽  
Author(s):  
Sarah Renno-Busch ◽  
Hanna Hildesheim ◽  
Janet M. T. van Uem ◽  
Ulrike Sünkel ◽  
Benjamin Röben ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Orthostatic Intolerance ◽  
Linear Regression Analysis ◽  
Health Related Quality ◽  
Autonomic Symptom ◽  
Autonomic Symptoms ◽  
Related Quality ◽  
Health Related

Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adults, independent of specific diseases, and HRQoL has not yet been assessed.Aim: To assess the frequency and the effect of autonomic symptoms in general, as well as orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor symptoms, on HRQoL in older adults.Methods: Cross-sectional data of the fourth visit of the Tübinger evaluation of Risk factors for Early detection of Neurodegeneration (TREND) study were included. Autonomic symptoms, as assessed with the Composite Autonomic Symptom Score 31 (COMPASS 31), were quantified and compared with HRQoL, as assessed with the EuroQol five-level version (EQ-5D-5L). Statistical analyses included Spearman's rank correlation and multiple linear regression analysis.Results: The analysis included 928 participants with a median of 68 years; 47% were women. Of those, 85% reported at least one autonomic symptom. Gastrointestinal and secretomotor symptoms were most common. The COMPASS 31 total score and all subdomains were significantly associated with reduced HRQoL. Among the subdomains, the strongest correlations with HRQoL were found for gastrointestinal and bladder symptoms. Overall, autonomic symptoms alone explained 20% of the variance of HRQoL; when depressive mood was added, the model explained 32%.Conclusion: Autonomic symptoms are associated with HRQoL and depressive symptoms in older adults.

scholarly journals Prevalence of Autonomic Dysfunction in Patients with Multiple Sclerosis

2015 ◽  
Vol 28 (1) ◽  
pp. 51 ◽  
Author(s):  
Bitia Vieira ◽  
Andreia Costa ◽  
Gonçalo Videira ◽  
Maria José Sá ◽  
Pedro Abreu
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Symptom Score ◽  
Disease Duration ◽  
Statistical Significance ◽  
Confounding Factors ◽  
Autonomic Symptom ◽  
Autonomic Symptoms ◽  
Multiple Sclerosis Patients

<strong>Background:</strong> Autonomic nervous system dysfunction is commonly seen in multiple sclerosis patients and should be explored in the routine evaluation. Composite Autonomic Symptom Score questionnaire was validated as a self-assessment instrument of autonomic symptoms.<br /><strong>Objectives:</strong> Determine the frequency of autonomic symptoms in multiple sclerosis patients through a Portuguese version of Composite Autonomic Symptom Score; compare questionnaire results between patients and a control group; assess the feasibility of this questionnaire application in multiple sclerosis Portuguese patients.<br /><strong>Material and Methods:</strong> This case-control study used a Portuguese translated version of Composite Autonomic Symptom Score to determine the frequency of autonomic symptoms in multiple sclerosis patients.<br /><strong>Results:</strong> One-hundred and three relapsing-remitting multiple sclerosis patients – median age 41 years, median disease duration 6 years, median EDSS score 1 - and 80 healthy subjects were included. Alterations in autonomic function were reported in 97.1% of the cases, with statistical significance in orthostatic intolerance and gastrointestinal domain scores. Nevertheless, the difference between multiple sclerosis patients (41.7%) without confounding factors that could interfere with autonomic dysfunction (i.e. comorbidities or medications) and controls showed no statistical significance.<br /><strong>Discussion:</strong> Our results may be related to the short disease duration, young age and lowdisability status of our patients unaffected by confounding factors. The questionnaire was not designed specifically for multiple sclerosis and it may not be as sensible to early autonomic symptoms as to more severe manifestations.<br /><strong>Conclusions:</strong> Further studies are needed to achieve more robust results, validate this questionnaire and assess its application in multiple sclerosis patients in Portugal.<br /><strong>Keywords:</strong> Autonomic Nervous System; Multiple Sclerosis; Portugal; Questionnaires.<strong><br /><br /></strong>

Correlation Between Intravesical Prostatic Protrusion with Prostate Volume, Uroflowmetry and International Prostate Symptom Score in Men Over 50 Years Old

2018 ◽  
Vol 24 (8) ◽  
pp. 6083-6086
Author(s):  
D Parikesit ◽  
C. A Mochtar ◽  
N Rasyid ◽  
R Umbas
Keyword(s):  
Symptom Score ◽  
International Prostate Symptom Score ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Correlation Coefficients ◽  
Abdominal Ultrasound ◽  
Significant Difference ◽  
Grade 3 ◽  
Post Hoc ◽  
Group 1

To evaluate the relationship between IPP, age, prostate volume, uroflowmetry result, PSA, and IPSS. We retrospectively studied 162 patients presenting with LUTS suggestive of BPH between January 2012 and December 2014, analyzing age, IPP, pressure flow study, prostate volume, PSA, and International Prostate Symptom Score. IPP was classified into three stages: grade 1 (≤5 mm), grade 2 (5 mm < IPP ≤ 10 mm), and grade 3 (>10 mm). Statistical analysis included Kruskall-Wallis with Mann-Whitney as post hoc analysis and Spearman’s correlation coefficients were performed. The mean age was 67±7.7 years old. Achieved IPP values were the following: grade 1–40 (24.7%), grade 2–60 (37%), and grade 3–62 (38.3%). Results show statistically significant difference between IPP grades Qmax, PVR, and PV (p ≤ 0.05). Mean difference between IPP groups were significant using Mann-Whitney post hoc test for Qmax, PVR, and PV between IPP group 1 and 2, PV between IPP group 1 and 3, and Qmax, PVR, and PV between IPP group 2 and 3. Spearman’s correlations coefficient show positive correlation between IPP and PV (r = 0.506, p ≤ 0.05), PVR (r = 0.341, p ≤ 0.05), and PSA (r = 0.253, p ≤ 0.05). Intravesical prostate protrusion measured through abdominal ultrasound are a non-invasive and accessible method that significantly correlates with peak flow rate (Qmax), prostate volume, post void residue, and prostate specific antigen.

Clinical Assessment of Autonomic Function in Fibromyalgia by the Refined and Abbreviated Composite Autonomic Symptom Score (COMPASS 31): A Case-Controlled Study

2021 ◽  
Vol 16 ◽  
Author(s):  
Basant K. Puri ◽  
Gary S. Lee
Keyword(s):  
Symptom Score ◽  
Autonomic Dysfunction ◽  
Autonomic Function ◽  
Orthostatic Intolerance ◽  
Fibromyalgia Impact Questionnaire ◽  
Controlled Study ◽  
Group Status ◽  
Cross Sectional ◽  
Autonomic Symptom ◽  
Revised Fibromyalgia Impact Questionnaire

Background: It has been shown that autonomic dysfunction in fibromyalgia can be assessed by the Composite Autonomic Symptom Score (COMPASS) questionnaire. More recently, a refined and much abbreviated 31-item version of the questionnaire has been developed, the COMPASS 31. Objectives: The study has the following objectives: First, to determine whether the COMPASS 31 can assess changes in autonomic function in fibromyalgia. Second, to assess whether the COMPASS 31 values in fibromyalgia patients are positively correlated with scores on the Revised Fibromyalgia Impact Questionnaire (FIQR). Method: A cross-sectional, case-controlled study was carried out with 25 fibromyalgia patients and 26 healthy controls. Results: The two groups were matched for age, sex and ethnicity, but not for body mass index (BMI). The total mean (standard error) COMPASS 31 for the fibromyalgia patients, 37.2 (1.8), differentiated the patients from the controls (9.5 (1.4); p < 0.00000001). The scores were greater in the fibromyalgia patients across all COMPASS 31 autonomic domains, namely orthostatic intolerance (p < 0.00000001), and vasomotor (p < 0.0001), secretomotor (p < 0.000001), gastrointestinal (p < 0.000001), bladder (p < 0.00001), and pupillomotor functions (p < 0.00000001). The total COMPASS 31 values were positively correlated with FIQR scores (rs = 0.45, p < 0.05). General linear modelling of the COMPASS 31 scores showed that only group status (fibromyalgia or control) was significant (p = 3.4 × 10-16), with age, sex and BMI being non-significant. Conclusion: This study confirms that non-pain autonomic dysfunction symptoms occur in fibromyalgia and can be assessed with COMPASS 31.

Student Perceptions of Face-to-Face and Online Discussions: The Advantage Goes To . . .

2008 ◽  
Vol 11 (4) ◽  
Author(s):  
Katrina A. Meyer
Keyword(s):  
Higher Education ◽  
Affirmative Action ◽  
Student Perceptions ◽  
Online Discussions ◽  
Political Tolerance ◽  
Self Assessment ◽  
Face To Face ◽  
The Face ◽  
Online Setting ◽  
And Gender

Thirteen students in a graduate-level course on Historical and Policy Perspectives in Higher Education held face-to-face and online discussions on five controversial topics: Diversity, Academic Freedom, Political Tolerance, Affirmative Action, and Gender. Students read materials on each topic and generated questions for discussion that were categorized by Bloom’s taxonomy so that the level of questions in the two discussion settings would be closely parallel. Upon completion of each discussion, they answered questions that addressed depth and length of the discussion, ability to remember, and a self-assessment of how the student learned. Students’ assessments show a consistent preference for the face-to-face discussion but a small number of students preferred the online setting. However, what is perhaps more interesting is a minority of approximately one-third of the students who perceived no difference between the settings, or that the two settings were perhaps complementary.

scholarly journals Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

2021 ◽  
Author(s):  
Alex Buoite Stella ◽  
Giovanni Furlanis ◽  
Nicolò Arjuna Frezza ◽  
Romina Valentinotti ◽  
Milos Ajcevic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Orthostatic Intolerance ◽  
Neurological Symptoms ◽  
Postural Tachycardia Syndrome ◽  
Symptom Scale ◽  
Autonomic Symptom ◽  
Postural Tachycardia ◽  
Ambulatory Services

AbstractThe autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is a simple and validated tool to assess dysautonomic symptoms. The aim of the present study was to administer the COMPASS-31 questionnaire to a sample of post-COVID patients with and without neurological complaints. Participants were recruited among the post-COVID ambulatory services for follow-up evaluation between 4 weeks and 9 months from COVID-19 symptoms onset. Participants were asked to complete the COMPASS-31 questionnaire referring to the period after COVID-19 disease. Heart rate and blood pressure were manually taken during an active stand test for OH and POTS diagnosis. One-hundred and eighty participants were included in the analysis (70.6% females, 51 ± 13 years), and OH was found in 13.8% of the subjects. Median COMPASS-31 score was 17.6 (6.9–31.4), with the most affected domains being orthostatic intolerance, sudomotor, gastrointestinal and pupillomotor dysfunction. A higher COMPASS-31 score was found in those with neurological symptoms (p < 0.01), due to more severe orthostatic intolerance symptoms (p < 0.01), although gastrointestinal (p < 0.01), urinary (p < 0.01), and pupillomotor (p < 0.01) domains were more represented in the non-neurological symptoms group. This study confirms the importance of monitoring ANS symptoms as a possible complication of COVID-19 disease that may persist in the post-acute period.

scholarly journals Self‐Assessment Quiz Taking Behaviour Analysis in an Online Course

2016 ◽  
Vol 19 (2) ◽  
pp. 15-31 ◽  
Author(s):  
Yasin Ozarslan ◽  
Ozlem Ozan
Keyword(s):  
Online Course ◽  
Distance Learners ◽  
Self Assessment ◽  
Chi Square ◽  
Final Exam ◽  
Undergraduate Level ◽  
Chi Square Test ◽  
Learner Profile ◽  
Exam Scores ◽  
And Gender

AbstractSelf-assessment is vital for online learning since it is one of the most essential skills of distance learners. In this respect, the purpose of this study was to understand learners’ self-assessment quiz taking behaviours in an undergraduate level online course. We tried to figure out whether there is a relation between self-assessment quiz taking behaviours and final exam scores or not. In addition, we investigated how self-assessment quiz taking behaviour differs with respect to learner profile. In line with this purpose, 677 students’ 6092 test events across Project Culture course on Sakai CLE LMS were analyzed. For the analysis of the quantitative data, one-way ANOVA, Chi-Square test of independence, independent-samples t-test and descriptive statistics were utilized. The results revealed that learners who attended self-assessment quizzes regularly had higher final exam scores than others who did not attend those quizzes. Also, they were more satisfied with the course than others study field. In addition, learners who attended selfassessment quizzes regularly had a higher degree of perceived learning. However, number of attempts to those quizzes does not have an effect on final exam scores. On the other hand, a statistically significant relationship was found between attempt number and gender in favour of female learners.

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