Bone Tissue Ablation with sub-µs Pulses of a Q-switch CO 2 Laser: Histological Examination of Thermal Side Effects

2002 ◽  
Vol 17 (4) ◽  
pp. 258-264 ◽  
Author(s):  
M.M. Ivanenko ◽  
S. Fahimi-Weber ◽  
T. Mitra ◽  
W. Wierich ◽  
P. Hering
Keyword(s):  
Side Effects ◽  
Bone Tissue ◽  
Histological Examination ◽  
Tissue Ablation

Treatment of human hyperprolactinaemia with a new dopamine agonist: CU 32085 (mesulergin)

1985 ◽  
Vol 110 (4) ◽  
pp. 433-439 ◽  
Author(s):  
D. Dewailly ◽  
P. Thomas ◽  
J. Buvat ◽  
J. L. Wemeau ◽  
J. C. Fourlinnie ◽  
...  
Keyword(s):  
Side Effects ◽  
Oral Administration ◽  
Dopamine Agonist ◽  
Histological Examination ◽  
Suppressive Effect ◽  
Normal Range ◽  
Tumour Shrinkage ◽  
Dose Dependent

Abstract. CU 38085 (mesulergin) was given at doses ranging from 0.5 to 5 mg/day to 37 patients with pathological hyperprolactinaemia of varying aetiology. The effectiveness of this drug on the suppression of hyperprolactinaemia and on the recovery of gonadal functions was equivalent to that of bromocriptine previously given to a different group of 83 hyperprolactinaemic patients. Tumour shrinkage during treatment with CU 32085 was ascertained in two cases of macroprolactinoma. Histological examination after adenomectomy revealed extensive peri-vascular fibrosis in both cases. In most patients, the efficient doses of CU 32085 were 5-fold lower than those of bromocriptine. After acute oral administration in 10 previously untreated patients, 0.5 mg of CU 32085 had a more prolonged suppressive effect on Prl levels than 2.5 mg of bromocriptine (approximately 18 vs 12 h). According to this, 0.5 mg CU 32085 once a day was sufficient to maintain Prl levels within the normal range in 16 patients. Side-effects were similar in nature and frequency to those induced by bromocriptine and seemed to be dose-dependent. They can be avoided by slowly increases of dose at initiation of treatment.

Bone tissue ablation with CO 2 lasers at different pulse durations

2005 ◽  
Author(s):  
M. Ivanenko ◽  
S. Afilal ◽  
M. Werner ◽  
P. Hering
Keyword(s):  
Bone Tissue ◽  
Tissue Ablation

Mechanism of precise tissue ablation with minimal side effects (under confined stress conditions of irradiation)

1995 ◽  
Author(s):  
Alexander A. Oraevsky ◽  
Rinat O. Esenaliev ◽  
Steven L. Jacques ◽  
Frank K. Tittel
Keyword(s):  
Side Effects ◽  
Stress Conditions ◽  
Tissue Ablation

scholarly journals Bioactivity and Delivery Strategies of Phytochemical Compounds in Bone Tissue Regeneration

2021 ◽  
Vol 11 (11) ◽  
pp. 5122
Author(s):  
Anna Valentino ◽  
Francesca Di Cristo ◽  
Michela Bosetti ◽  
Amal Amaghnouje ◽  
Dalila Bousta ◽  
...  
Keyword(s):  
Side Effects ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Large Scale ◽  
Stability Limit ◽  
Cost Effective ◽  
Biological Properties ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Bone Tissue Regeneration

Plant-derived secondary metabolites represent a reservoir of phytochemicals for regenerative medicine application because of their varied assortment of biological properties including anti-oxidant, anti-inflammatory, antibacterial, and tissue remodeling properties. In addition, bioactive phytochemicals can be easily available, are often more cost-effective in large-scale industrialization, and can be better tolerated compared to conventional treatments mitigating the long-lasting side effects of synthetic compounds. Unfortunately, their poor bioavailability and lack of long-term stability limit their clinical impact. Nanotechnology-based delivery systems can overcome these limitations increasing bioactive molecules’ local effectiveness with reduction of the possible side effects on healthy bone. This review explores new and promising strategies in the area of delivery systems with particular emphasis on solutions that enhance bioavailability and/or health effects of plant-derived phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and curcumin in bone tissue regeneration.

Curcumin: A Literature Review of Its Effects on Bone Health and Osteoporosis

2021 ◽  
Vol 10 ◽  
pp. 2129
Author(s):  
Zahra Moradi ◽  
Tofigh Jalalifar ◽  
Sarvenaz Roshanisefat ◽  
Sheida Jamalnia ◽  
Elnaz Reihani ◽  
...  
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Alternative Medicine ◽  
Bone Tissue ◽  
Bone Health ◽  
Active Component ◽  
Therapeutic Agent ◽  
Polyphenolic Compound ◽  
Therapeutic Properties

Natural compounds can be used as a complementary or alternative medicine for many diseases, such as osteoporosis. Curcumin, a polyphenolic compound and the major active component of turmeric, is reported to play important roles in bone health and osteoporosis. By affecting proliferation, differentiation, lifespan, and activity of osteoblasts and osteoclasts, curcumin can directly modulate bone tissue hemostasis. Due to its insignificant side effects and several therapeutic properties, such as antioxidant, anticancer, antibacterial, antifungal, anti-inflammatory, and antirheumatic, it could be a potential therapeutic agent to prevent and treat osteoporosis. This review aimed to summarize the most important findings of in vitro, animal, and human studies in an effort to clarify the possible effects of curcumin on osteoporosis and to explain the exact molecular mechanism by which curcumin exerts its action.[GMJ.2021;10:e2129] DOI:10.31661/gmj.v10i0.2129 

scholarly journals A histological evaluation of bone calluses in the treatment of tibia fractures in sheep with the use of a semicircular fixator 

2010 ◽  
Vol 55 (No. 11) ◽  
pp. 547-550
Author(s):  
Z. Adamiak ◽  
T. Rotkiewicz
Keyword(s):  
Fracture Healing ◽  
Bone Tissue ◽  
Histological Examination ◽  
Bone Growth ◽  
Compact Bone ◽  
Tibia Fracture ◽  
Histological Evaluation ◽  
Fracture Treatment ◽  
Compact Bone Tissue ◽  
Tibia Fractures

This study discusses the results of a histological examination of bone calluses in the treatment of tibia fractures in sheep with the involvement of a semi-circular fixator. In all sheep, callus samples revealed the presence of well-developed, compact bone tissue in the area of fracture healing. It was found that the use of a semi-circular fixator promoted bone growth, and that it is an effective method for tibia fracture treatment in sheep.

scholarly journals Post COVID-19 invasive mucormycosis and actinomycosis co-infection: a case report

2021 ◽  
Author(s):  
Neha Mishra ◽  
Venkata Sai Shashank Mutya ◽  
Irfan Ibrahim K. ◽  
Girish Rai
Keyword(s):  
Case Report ◽  
Bone Tissue ◽  
Histological Examination ◽  
Surgical Management ◽  
Gold Standard ◽  
Bacterial Culture ◽  
Beta Lactams ◽  
Necrotic Bone ◽  
Sulfur Granules ◽  
Aggressive Debridement

<p>Actinomyces are commensals of human oropharynx and actinomycosis is considered mainly as an endogenous infection that is triggered by a mucosal lesion. Typically, the disease presents as a slowly progressive painless indurated mass evolving into multiple abscesses with draining sinus tracts sometimes expressing a typical yellow exudate with characteristic sulfur granules. The gold standard of diagnosis is histological examination and bacterial culture of the tissue. Most isolates are susceptible to beta lactams and they are the treatment of choice along with surgical management with drainage of abscesses and excision of recalcitrant fibrotic lesions and debridement of necrotic bone tissue. Here we present a case of 37-year-old male patient who has developed severe COVID-19 infection following which he developed invasive mucormycosis followed by actinomycosis. We postulate that the lymphopenia and the use of immunosuppressants used in treatment of COVID-19 lead to mucormycosis and aggressive debridement used as a strategy in treatment of mucormycosis led to colonization of actinomyces leading to cervicofacial actinomycosis.</p>

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