Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association

Background: In the last 10 years, the management of patients with gastric cancer liver metastases (GCLM) has changed from chemotherapy alone, towards a multidisciplinary treatment with liver surgery playing a leading role. The aim of this systematic review and meta-analysis is to assess the efficacy of hepatectomy for GCLM and to analyze the impact of related prognostic factors on long-term outcomes. Methods: The databases PubMed (Medline), EMBASE, and Google Scholar were searched for relevant articles from January 2010 to September 2020. We included prospective and retrospective studies that reported the outcomes after hepatectomy for GCLM. A systematic review of the literature and meta-analysis of prognostic factors was performed. Results: We included 40 studies, including 1573 participants who underwent hepatic resection for GCLM. Post-operative morbidity and 30-day mortality rates were 24.7% and 1.6%, respectively. One-year, 3-years, and 5-years overall survival (OS) were 72%, 37%, and 26%, respectively. The 1-year, 3-years, and 5-years disease-free survival (DFS) were 44%, 24%, and 22%, respectively. Well-moderately differentiated tumors, pT1–2 and pN0–1 adenocarcinoma, R0 resection, the presence of solitary metastasis, unilobar metastases, metachronous metastasis, and chemotherapy were all strongly positively associated to better OS and DFS. Conclusion: In the present study, we demonstrated that hepatectomy for GCLM is feasible and provides benefits in terms of long-term survival. Identification of patient subgroups that could benefit from surgical treatment is mandatory in a multidisciplinary setting.

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A Rare Cause of Failure to Thrive: A Case of a Primary Gastric Cancer in a Patient with Metastatic Renal Cell Carcinoma and a Review of the Literature on Management

The American Journal of Gastroenterology ◽

10.14309/00000434-200910003-00594 ◽

2009 ◽

Vol 104 ◽

pp. S222

Author(s):

Viplove Senadhi ◽

Rodrigo Erlich

Keyword(s):

Gastric Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Failure To Thrive ◽

Review Of The Literature ◽

Primary Gastric Cancer ◽

Cause Of Failure

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Remnant Gastric Cancer After Roux-en-Y Gastric Bypass: Narrative Review of the Literature

Obesity Surgery ◽

10.1007/s11695-019-03892-7 ◽

2019 ◽

Vol 29 (8) ◽

pp. 2609-2613 ◽

Cited By ~ 11

Author(s):

Stefania Tornese ◽

Alberto Aiolfi ◽

Gianluca Bonitta ◽

Emanuele Rausa ◽

Guglielmo Guerrazzi ◽

...

Keyword(s):

Gastric Cancer ◽

Gastric Bypass ◽

Narrative Review ◽

Remnant Gastric Cancer ◽

Review Of The Literature

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Surgery for solitary pulmonary metastasis after curative gastrectomy for gastric cancer: Contribution to the long-term survival.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.3_suppl.102 ◽

2015 ◽

Vol 33 (3_suppl) ◽

pp. 102-102

Author(s):

Shigeya Hayashi ◽

Kenki Segami ◽

Taiichi Kawabe ◽

Toru Aoyama ◽

Yousuke Makuuchi ◽

...

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Overall Survival ◽

Pulmonary Metastasis ◽

Pulmonary Resection ◽

Curative Gastrectomy ◽

Term Survival ◽

Long Term Survival ◽

Primary Gastric Cancer

102 Background: Surgical resection is rarely indicated for pulmonary recurrence after curative gastrectomy for gastric cancer because most tumors recurred as multiple nodules or carcinomatous lymphangitis / pleuritis and prognosis is extremely poor. However, some investigators reported a sporadic case developing a solitary pulmonary metastasis which was surgically resected and resulted in a relatively favorable clinical outcome. The present study aimed to clarify contribution of surgery for solitary pulmonary recurrence to the long-term survival. Methods: We performed a systematic review of the literature by searching the words of “stomach”, “neoplasms”, “lung”, and “metastasis” in the Pubmed and Japanese ICHUSHI database, and analyzed the cases reporting on resection of solitary pulmonary metastasis after curative gastrectomy for gastric cancer together with our cases treated at our hospital. Overall survival was estimated by Kaplan-Meier method. Results: A total of 45 patients, 42 from a systematic review and 3 from our cases, were examined. Median age (range) was 67 years (31–84 years). Primary gastric cancer had the following characteristics; histologically differentiated type in 30 patients, undifferentiated type in 2, and unknown in 13 patients and tumor depth of T1 in 3, T2 in 6, T3 in 13, T4 in 9, and unknown in 6. Surgery for the primary gastric cancer was total gastrectomy in 30 patients and distal one in 15. The median (range) disease-free survival (DFS) between initial gastric resection and the detection of pulmonary metastasis was 28.0 months (5-128 months). Surgery for pulmonary tumor was lobectomies in 20 patients, segmentectomies in 3, wedge resections in 18, and unknown in 4. Only 4 patients received adjuvant chemotherapy after pulmonary resection. The median (range) follow-up period after pulmonary surgery was 20 months (3-98 months). The overall survival after pulmonary resection was 86% at 1-year, 62% at 3-year, and 56% at 5-year with the median (range) survival time of 67 months (3-98 months). Conclusions: Surgery for solitary pulmonary recurrence could contribute to the long-term survival.

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