Control of cell proliferation kinetics of tumor in neoadjuvant chemotherapy for advanced oral squamous cell carcinoma and its prognostic implications

2002 ◽  
Vol 7 (3) ◽  
pp. 138-144 ◽  
Author(s):  
M. Noguchi ◽  
H. Kinjyo ◽  
A. Miyazaki ◽  
H. Kubota ◽  
G. Kohama



2010 ◽  
Vol 52 (3) ◽  
pp. 417-424 ◽  
Author(s):  
Satiro Watanabe ◽  
Rogério Watanabe ◽  
Angélica F. Oton-Leite ◽  
Rita de C. G. Alencar ◽  
José C. Oliveira ◽  
...  


2021 ◽  
Vol 11 (8) ◽  
pp. 1571-1575
Author(s):  
Guowu Ma ◽  
Jia Hou ◽  
Jiezi Qiu ◽  
Jianlin Fan ◽  
Jianxin Yang

Oral squamous cell carcinoma (OSCC) had the poor prognosis. miR-155 was involved in some diseases. However, whether BMSCs with high expression miR-155 affect the proliferation and metastasis of OSCC is unclear. Our study aims to assess BMSCs’ effect on OSCC cells. miR-155 level in OSCC tumor tissues was analyzed. BMSCs were transfected with miR-155 followed by analysis of cell proliferation by MTT assay, cell apoptosis and migration, and MMP-9 level by ELISA and PTEN12 level. In the tumor tissue, miR-155 level was significantly increased (P <0.05). Co-culture of BMSCs with high expression miR-155 with OSCC cells could significantly promote OSCC cell proliferation and reduced cell apoptotic activity, increased cell migration and MMP-9 secretion as well as downregualted PTEN12 expression (P <0.05). In conclusion, miR-155 was increased in the OSCC patients and BMSCs of high expression miR-155 could promote the proliferation and metastasis of OSCC by regulating PTEN12.





Author(s):  
SYLVIE BRENER ◽  
DENISE TOSTES OLIVEIRA ◽  
MIGUEL ÁNGEL GONZALEZ-MOLES




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