Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters

Abstract Purpose To analyze whether the T1 relaxation time of the liver is a good predictor of significant liver fibrosis and whether normalization to the blood pool improves the predictive value. Methods This prospective study was conducted between 03/2016 and 02/2018. One hundred seventy-three patients underwent multiparametric liver MRI at 3 T. The T1 relaxation time was measured in the liver and the spleen, in the aorta, the portal vein, and the inferior vena cava (IVC). T1 relaxation times with and without normalization to the blood pool were compared between patients with (n = 26) and without (n = 141) significant liver fibrosis, based on a cutoff value of 3.5 kPa in MRE as the noninvasive reference standard. For statistics, Student’s t test, receiver operating characteristic (ROC) curve analysis, and Pearson’s correlation were used. Results The T1 relaxation time of the liver was significantly longer in patients with liver fibrosis, both with and without blood pool normalization (p < 0.001). T1 relaxation time of the liver allowed prediction of significant liver fibrosis (AUC = 0.88), while normalization to the IVC resulted in a slightly lower performance (AUC = 0.82). The lowest performance was achieved when the T1 relaxation times of the liver were normalized to the aorta (AUC = 0.66) and to the portal vein (AUC = 0.62). The T1 relaxation time of the spleen detected significant liver fibrosis with an AUC of 0.68, and 0.51–0.64 with normalization to the blood pool. Conclusion The T1 relaxation time of the liver is a good predictor of significant liver fibrosis. However, normalization of the blood pool did not improve the predictive value. Key Points • The T1 relaxation time of the liver is a good predictor of significant liver fibrosis. • Normalization to the blood pool did not improve the predictive value of T1 mapping. • If the blood pool normalization was weighted 30% to the aorta and 70% to the portal vein, the performance was better than normalization to the aorta alone but still lower than normalization to the IVC.

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T1 Relaxation Time of Achilles Tendon at 3 Tesla with Special Reference to Relevant Clinical Score: A Preliminary Study

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405615666181205130816 ◽

2020 ◽

Vol 16 (2) ◽

pp. 164-173

Author(s):

Zeineb Tbini ◽

Mokhtar Mars ◽

Mouna Bouaziz

Keyword(s):

Relaxation Time ◽

Achilles Tendon ◽

Clinical Score ◽

3 Tesla ◽

Acquisition Time ◽

Short Term ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Spin Echo Sequence ◽

Significant Difference

Purpose: The purpose of this study was to investigate T1 relaxation time of the human Achilles tendon, to test its short-term repeatability as well as the minimal detectable change, and to assess the extent that correlate with clinical symptoms. Methods: Twenty asymptomatic volunteers and eighteen patients with clinically and sonographically confirmed tendinopathy were scanned for ankle using a 3 Tesla (T) MR scanner. T1 maps were calculated from a variable flip angle gradient echo Ultra-short echo time sequence (VFA-GE UTE) and inversion recovery spin echo sequence (IR-SE) using a self-developed matlab algorithm in three regions of interest of Achilles Tendon (AT). Signal to Noise Ratio (SNR) between the two sequences was evaluated. INTRA-class Correlation Coefficient (ICC), Coefficient of Variation (CV) and the Least Significant Change (LSC) were calculated, to test short-term repeatability of T1. Subjects were assessed by the VISA-A clinical score. P values less than 0.005 were considered statistically significant. Results: Mean T1 values were 427.09 ± 53.37 ms and 528.70 ± 103.50 ms using IR-SE sequence and 575.43 ± 110.60 ms and 875.81 ± 425.77 ms with VFA-GE UTE sequence in the whole AT for volunteers and patients, respectively. : T1 values showed a significant difference between volunteers and patients (P=0.001). Regional variation of T1 in healthy and tendinopathic AT were greater for VFA-GE UTE sequence than for IR-SE sequence. VFA-GE UTE sequence showed clearly higher SNR compared to IR-SE sequence. Short-term repeatability of T1 values for volunteers showed an LSC of 22% and 14% for IR-SE sequence and VFA-GE UTE sequence, respectively. For patients, LSC was 14% and 5% for IR-SE sequence and VFA-GE UTE sequence, respectively. There was no correlation between T1 and VISA-A clinical score (p>0.005). Conclusion: VFA-GE UTE sequence used for T1 mapping calculation demonstrated short acquisition time and clearly high SNR. Results revealed that T1 relaxation time can be used as a biomarker to differentiate between healthy and pathologic Achilles tendon. However, T1 showed no correlation with the VISA-A clinical score.

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Physiologic Changes in Breast Magnetic Resonance Imaging during the Menstrual Cycle: Perfusion Imaging, Signal Enhancement, and Influence of the T1 Relaxation Time of Breast Tissue

The Breast Journal ◽

10.1111/j.1075-122x.2005.21499.x ◽

2005 ◽

Vol 11 (4) ◽

pp. 236-241 ◽

Cited By ~ 115

Author(s):

Jean-Paul Delille ◽

Priscilla J. Slanetz ◽

Eren D. Yeh ◽

Daniel B. Kopans ◽

Leoncio Garrido

Keyword(s):

Magnetic Resonance Imaging ◽

Relaxation Time ◽

Menstrual Cycle ◽

Magnetic Resonance ◽

Breast Tissue ◽

Breast Magnetic Resonance Imaging ◽

Resonance Imaging ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Breast Magnetic Resonance

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Hindbrain glucagon-like peptide-1 receptors (GLP-1R) mediate the eating-inhibitory effect of hepatic portal vein (HPV) GLP-1 infusions

Appetite ◽

10.1016/j.appet.2010.04.158 ◽

2010 ◽

Vol 54 (3) ◽

pp. 668 ◽

Cited By ~ 2

Author(s):

G. Pacheco-López ◽

M. Punjabi ◽

M. Graber ◽

N. Geary ◽

M. Arnold ◽

...

Keyword(s):

Portal Vein ◽

Inhibitory Effect ◽

Hepatic Portal Vein ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Hepatic Portal

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Complete pancreatic encasement of the proximal hepatic portal vein: A previously undescribed congenital anomaly

British Journal of Surgery ◽

10.1002/bjs.1800840613 ◽

1997 ◽

Vol 84 (6) ◽

pp. 785-785 ◽

Cited By ~ 22

Author(s):

Y. Hamanaka ◽

J. Evans ◽

G. Sagar ◽

J. P. Neoptolemos

Keyword(s):

Congenital Anomaly ◽

Portal Vein ◽

Hepatic Portal Vein ◽

Hepatic Portal

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Influence of a mobilization of the mesentery on the hepatic portal vein capacity measured with doppler echo

International Journal of Osteopathic Medicine ◽

10.1016/j.ijosm.2008.08.018 ◽

2008 ◽

Vol 11 (4) ◽

pp. 160-161

Author(s):

P.L.S. van Dun ◽

E. Dobbelaere ◽

P. Dillies ◽

F. Inghelbrecht ◽

P. Van Eeghem ◽

...

Keyword(s):

Portal Vein ◽

Hepatic Portal Vein ◽

Hepatic Portal

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Blood-brain barrier breakdown in non-enhancing multiple sclerosis lesions detected by 7-Tesla MP2RAGE ΔT1 mapping

PLoS ONE ◽

10.1371/journal.pone.0249973 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0249973

Author(s):

Seongjin Choi ◽

Margaret Spini ◽

Jun Hua ◽

Daniel M. Harrison

Keyword(s):

Multiple Sclerosis ◽

Relaxation Time ◽

White Matter ◽

Blood Brain Barrier ◽

White Matter Lesions ◽

Brain Barrier ◽

7 Tesla ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Blood Brain

Although the blood-brain barrier (BBB) is altered in most multiple sclerosis (MS) lesions, gadolinium enhancement is seen only in acute lesions. In this study, we aimed to investigate gadolinium-induced changes in T1 relaxation time in MS lesions on 7-tesla (7T) MRI as a means to quantify BBB breakdown in non-enhancing MS lesions. Forty-seven participants with MS underwent 7T MRI of the brain with a magnitude-prepared rapid acquisition of 2 gradient echoes (MP2RAGE) sequence before and after contrast. Subtraction of pre- and post-contrast T1 maps was used to measure T1 relaxation time change (ΔT1) from gadolinium. ΔT1 values were interrogated in enhancing white matter lesions (ELs), non-enhancing white matter lesions (NELs), and normal appearing white matter (NAWM) and metrics were compared to clinical data. ΔT1 was measurable in NELs (median: -0.139 (-0.304, 0.174) seconds; p < 0.001) and was negligible in NAWM (median: -0.001 (-0.036, 0.155) seconds; p = 0.516). Median ΔT1 in NELs correlated with disability as measured by Expanded Disability Status Scale (EDSS) (rho = -0.331, p = 0.026). Multiple measures of NEL ΔT1 variability also correlated with EDSS. NEL ΔT1 values were greater and more variable in patients with progressive forms of MS and greater in those not on MS treatment. Measurement of the changes in T1 relaxation time caused by contrast on 7T MP2RAGE reveals clinically relevant evidence of BBB breakdown in NELs in MS. This data suggests that NEL ΔT1 should be evaluated further as a biomarker for disease severity and treatment effect in MS.

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