Antioxidant and Antiamnestic Effects of Potassium Comenate and Comenic Acid under Conditions of Normobaric Hypoxia with Hypercapnia

2017 ◽  
Vol 163 (3) ◽  
pp. 344-348 ◽  
Author(s):  
L. V. Shurygina ◽  
E. I. Zlishcheva ◽  
A. N. Kravtsova ◽  
A. A. Kravtsov
Keyword(s):  
Normobaric Hypoxia ◽  
Comenic Acid ◽  
Hypoxia With Hypercapnia ◽  
Potassium Comenate

scholarly journals The experimental study of the antihypoxic properties of harmine hydrochloride

Biomeditsina ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 71-78
Author(s):  
S. M. Adekenov ◽  
V. N. Karkischenko ◽  
M. S. Nesterov ◽  
D. A. Abaimov ◽  
A. K. Sariev
Keyword(s):  
Experimental Study ◽  
Life Expectancy ◽  
Hypobaric Hypoxia ◽  
Normobaric Hypoxia ◽  
Antihypoxic Activity ◽  
Reference Drug ◽  
Small Doses ◽  
Hypoxia With Hypercapnia ◽  
Antihypoxic Effect ◽  
Compensatory Effect

A derivative of the beta-carboline alkaloid harmine — the drug harmine hydrochloride was studied for the presence of antihypoxic properties in models of hypobaric hypoxia and normobaric hypoxia with hypercapnia. It was found that harmine hydrochloride does not have a signifi cant compensatory effect in the normobaric hypoxia test with hypercapnia. At the same time, harmine hydrochloride in small doses (2.5 and 5 mg/kg) has antihypoxic activity in the hypobaric hypoxia test, which is expressed in a statistically signifi cant increase in the life expectancy of animals treated with the drug, compared with the control, in conditions of hypoxia. According to the antihypoxic effect, harmine hydrochloride at doses of 2.5 and 5 mg/kg was found to be comparable with the reference drug (mexidol, 100 mg/kg).

scholarly journals STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.02,6]DECAN-4-ON

2019 ◽  
Vol 8 (1) ◽  
pp. 86-90
Author(s):  
T. A. Sapozhnikova ◽  
N. S. Makara ◽  
S. F. Gabdrakhmanova ◽  
R. Yu. Khisamutdinova
Keyword(s):  
Lipid Peroxidation ◽  
Life Span ◽  
Passive Avoidance ◽  
Day Treatment ◽  
Normobaric Hypoxia ◽  
Laboratory Animals ◽  
Avoidance Reaction ◽  
Hypoxia With Hypercapnia ◽  
Peroxidation Processes ◽  
The Brain

Introduction. Nootropic drugs are components of complex therapy for various neurological dysfunctions. One of the classes of ND are pyrrolidone derivatives, which, in addition to a direct effect on cognitive functions, increase the brain's resistance to hypoxia. Aim. The work was to study the effect of the 3-aminopyrrolidin-2-one derivative containing the norbornane fragment (P-11) on different memory phases in rats and to evaluate its antihypoxic properties. Materials and methods. The effect of P-11 on memory was assessed on passive avoidance test (PAT) in rats. The antihypoxic properties of P-11 were studied on a model of acute normobaric hypoxia with hypercapnia, assessing the life span of laboratory animals and the level of lipid peroxidation processes in the brain. Results and discussion. It was shown that the introduction of P-11 at different stages of the development of passive avoidance reaction improves the ability of animals to learn and extract a memorable trace of pain stimulation 24 hours after the development of a reflex. On a model of normobaric hypoxia with a single injection, P-11 showed a tendency to increase the life span of rats relative to the control, and with a 14-day treatment, pronounced antihypoxic properties were observed compared with other pyrrolidone derivatives, pyracetam and phenotropil, which manifested in an increase in life span of mice, as well as in lowering lipid peroxidation processes in brain tissue. Conclusion. Thus, it was shown that a new derivative 3-aminopyrrolidin-2-it exhibits nootropic and antihypoxic properties.

INFLUENCE OF DEUTERIUM-DEPLETED DRINKING DIET ON THE FUNCTIONAL STATE OF THE CENTRAL NERVOUS SYSTEM OF ANIMALS UNDER RATE AND NORMOBARIC HYPOXIA WITH HYPERCAPNIA

2021 ◽  
Author(s):  
Anna Elkina ◽  
◽  
Stanislav V. Kozin ◽  
Alexandr A. Kravtsov ◽  
◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional State ◽  
Control Level ◽  
Normobaric Hypoxia ◽  
Hypoxic Exposure ◽  
Hypoxia With Hypercapnia ◽  
The Central Nervous System ◽  
Deuterium Depleted Water

The effect of long-term (42 days) introduction of deuterium-depleted water into the diet of rats on the functional state of the central nervous system under normal conditions and normobaric hypoxia with hypercapnia was studied. It was also established that the use of deuterium-de-pleted water both under normal conditions and after stressful exposure contributes to a sig-nificant decrease in the emotional anxiety of animals. Long-term use of deuterium-depleted water before hypoxic exposure (exposure to the amnestic factor) contributes to the preservation of learning and memory at the control level, i.e. has a pronounced protective antiamnesic effect.

Comparative Analysis of Antioxidant Properties of Comenic Acid and Potassium Comenate in Modeled Immobilization Stress

2015 ◽  
Vol 159 (4) ◽  
pp. 466-468 ◽  
Author(s):  
L. V. Shurygina ◽  
E. I. Zlishcheva ◽  
V. V. Khablyuk ◽  
A. N. Kravtsova ◽  
N. O. Abramova ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immobilization Stress ◽  
Antioxidant Properties ◽  
Comenic Acid ◽  
Potassium Comenate

Peculiarities of psychophysiological adaptation of marine cadets during professional training in marine specialities

2019 ◽  
pp. 19-24 ◽  
Author(s):  
Pavel F. Kiku ◽  
Evgeniy V. Zhovnerchuk ◽  
Irina P. Melnikova ◽  
Natalya I. Izmerovа ◽  
Kseniya M. Sabirova
Keyword(s):  
Professional Training ◽  
Reference Group ◽  
Educational Institution ◽  
Normobaric Hypoxia ◽  
Medical Rehabilitation ◽  
Occupational Training ◽  
Prophylactic Measures ◽  
Study Results ◽  
Intermittent Normobaric Hypoxia ◽  
Emotional Strain

Introduction.Occupational environment and occupational factors determine peculiarities in mastering marine occupations. Some unfavorable occupational educational and ecologic factors appear to cause high level of physical and psychoemotional stress.Objectiveis to study features of adaptation to study during occupational training in marine specialties in cadets of a higher marine educational institution, and to conduct medical and psychological rehabilitation.Material and methods.Examination covered 120 male cadets of 3rd and 4thyears of study: 70 (main group) and 50 (reference group). The age of the cadets was 21±0.4 years. To study characteristics of the cadets’ adaptation, the authors used psychological methods — Spielberger’s State Trait Anxiety Scale and Nemchin’s «Method measuring severity of neuropsychic stress». Statistical analysis was performed with software «Statistica for Windows 10.0».Study results and discussion.After 3 months of sailing, majority of the cadets appeared to be dysadapted. Deep clinical and laboratory studies proved that 39.4% of the examinees were apparently healthy and 60.6% of those had chronic diseases. Thus, a system of medical psychologic rehabilitation was designed, comprising primary and secondary prophylaxis methods. One of these prevention methods is a recovery complex of measures with intermittent normobaric hypoxia modified by us. The authors determined optimal regime of using intermittent normobaric hypoxia combined with medical rehabilitation.Conclusions.Adaptational state in cadets of high marine educational institution during professional training in marine occupations is characterized by increased psycho-emotional strain, anxiety and observed in 57.3% of the examinees. Findings are that after 3 months of sailing, majority of the cadets are dysadapted. To prevent morbidity and preserve health, the authors suggested a system of medical and psychologic rehabilitation including intermittent normobaric hypoxia with rehabilitation medical complex. The medical and prophylactic measures help to solve problems of psycho-emotional stress, lower morbidity parameters, prevent dysadaptation disorders, relieve functional overstrain. That preserves and improves the cadets’ health and forms an important stage in prevention of mental and behavioral disorders related to work.

ВЛИЯНИЕ ОБЕДНЕННОГО ДЕЙТЕРИЕМ ПИТЬЕВОГО РАЦИОНА НА ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ ЖИВОТНЫХ В УСЛОВИИ ГИПОКСИИ

2020 ◽  
Vol 65 (6) ◽  
pp. 1196-1202
Author(s):  
С.В. Козин ◽  
◽  
А.А. Кравцов ◽  
Э.И. Злищева ◽  
Л.В. Шурыгина ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Control Level ◽  
Learning Ability ◽  
Hypoxic Exposure ◽  
Amnestic Effect ◽  
Hypoxia With Hypercapnia ◽  
Antiamnestic Effect ◽  
The Central Nervous System ◽  
Deuterium Depleted Water

The effects of prolonged (42 days) addition of deuterium-depleted water into rat’s diet on the functional state of the central nervous system in normal conditions and under conditions of normobaric hypoxia with hypercapnia were studied. It was also established that the use of deuterium-depleted water both in normal conditions and after exposure to oxidative stress contributes to a significant reduction in the emotional anxiety of animals. Prolonged use of deuterium-depleted water before hypoxic exposure (amnestic effect) helps to maintain learning and memory at the control level, i.e. it has a pronounced protective antiamnestic effect. In normal conditions, deuterium-depleted water does not affect the learning ability of animals.

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