Left atrial minimum volume is more strongly associated with N-terminal pro-B-type natriuretic peptide than the left atrial maximum volume in a community-based sample

Abstract Arithmetic matroids arising from a list A of integral vectors in Zn are of recent interest and the arithmetic Tutte polynomial MA(x, y) of A is a fundamental invariant with deep connections to several areas. In this work, we consider two lists of vectors coming from the rows of matrices associated to a tree T. Let T = (V, E) be a tree with |V| = n and let LT be the q-analogue of its Laplacian L in the variable q. Assign q = r for r ∈ ℤ with r/= 0, ±1 and treat the n rows of LT after this assignment as a list containing elements of ℤn. We give a formula for the arithmetic Tutte polynomial MLT (x, y) of this list and show that it depends only on n, r and is independent of the structure of T. An analogous result holds for another polynomial matrix associated to T: EDT, the n × n exponential distance matrix of T. More generally, we give formulae for the multivariate arithmetic Tutte polynomials associated to the list of row vectors of these two matriceswhich shows that even the multivariate arithmetic Tutte polynomial is independent of the tree T. As a corollary, we get the Ehrhart polynomials of the following zonotopes: - ZEDT obtained from the rows of EDT and - ZLT obtained from the rows of LT. Further, we explicitly find the maximum volume ellipsoid contained in the zonotopes ZEDT, ZLT and show that the volume of these ellipsoids are again tree independent for fixed n, q. A similar result holds for the minimum volume ellipsoid containing these zonotopes.

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Isolated atrial amyloid: a potential contributor to morbidity and mortality following cardiac surgery

Interactive CardioVascular and Thoracic Surgery ◽

10.1093/icvts/ivz051 ◽

2019 ◽

Vol 29 (2) ◽

pp. 187-192 ◽

Cited By ~ 1

Author(s):

Kunal Bhakhri ◽

Sara Volpi ◽

Davide Gori ◽

Martin Goddard ◽

Jason M Ali ◽

...

Keyword(s):

Cardiac Surgery ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Left Atrial ◽

Cardiac Amyloidosis ◽

Left Atrial Appendage ◽

Atrial Appendage ◽

Amyloid A ◽

The Impact ◽

Atrial Natriuretic

AbstractOBJECTIVESDiffuse cardiac amyloidosis is a significant diagnosis with a poor prognosis. Isolated atrial amyloidosis (IAA) is the most common form of cardiac amyloidosis caused by accumulation of alpha-atrial natriuretic peptide. IAA has been associated with dysrhythmia, but otherwise remains a poorly characterized condition. The impact of incidental IAA on postoperative outcome following cardiac surgery has not previously been reported. The purpose of this study was to examine the impact of isolated atrial amyloid on patient outcomes following cardiac surgery.methodsA retrospective analysis was performed of all patients having excision of the left atrial appendage during cardiac surgery at our centre over a 5-year period. Patients with histological evidence of IAA were compared to patients without this diagnosis. IAA was diagnosed by immunohistochemistry for atrial natriuretic peptide.RESULTSA total of 167 patients underwent left atrial appendage excision and of these 26 (15.6%) were found to have IAA. Preoperative characteristics were similar between the 2 groups. A significantly greater proportion of patients with IAA experienced dysrhythmia requiring implantation of a permanent pacemaker (23.1% vs 7.8%, P = 0.03). There was also a significantly elevated incidence of perioperative death in the IAA group (11.5% vs 1.4%, P = 0.03) and inferior 1-year survival (84.6% vs 96.5%, P = 0.02).CONCLUSIONSThe presence of IAA may be associated with inferior outcomes following cardiac surgery, with increased morbidity in the early postoperative period and inferior long-term survival. Knowledge of the diagnosis preoperatively may facilitate management of patients.

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Plasma B-Type Natriuretic Peptide Is Useful for Cardiovascular Risk Assessment in Community-Based Diabetes Subjects

International Heart Journal ◽

10.1536/ihj.53.176 ◽

2012 ◽

Vol 53 (3) ◽

pp. 176-181 ◽

Cited By ~ 10

Author(s):

Masayuki Onodera ◽

Motoyuki Nakamura ◽

Fumitaka Tanaka ◽

Tomohiro Takahashi ◽

Shinji Makita ◽

...

Keyword(s):

Risk Assessment ◽

Cardiovascular Risk ◽

Natriuretic Peptide ◽

Cardiovascular Risk Assessment ◽

Community Based

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The Effects of Left Atrial Appendage Closure on Natriuretic Peptide Levels and Cardiac Filling Pressures

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2049 ◽

2020 ◽

Author(s):

Z. Vazquez ◽

G. Cagle ◽

A. Chu ◽

P. Gordon ◽

P. Haines ◽

...

Keyword(s):

Natriuretic Peptide ◽

Left Atrial ◽

Left Atrial Appendage ◽

Atrial Appendage ◽

Left Atrial Appendage Closure ◽

Cardiac Filling

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Natriuretic peptide gene expression in DOCA-salt hypertension after blockade of type B endothelin receptor

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00468.2001 ◽

2002 ◽

Vol 282 (3) ◽

pp. H1127-H1134 ◽

Cited By ~ 8

Author(s):

Liliana G. Bianciotti ◽

Adolfo J. de Bold

Keyword(s):

Gene Expression ◽

Left Ventricular Hypertrophy ◽

Natriuretic Peptide ◽

Left Atrial ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Mrna Levels ◽

Collagen Iii ◽

Salt Hypertension ◽

Np Gene

We investigated the effect of long-term in vivo blockade of the ET-1 receptor subtype B (ETB) with A-192621, a selective ETBantagonist, on atrial and ventricular natriuretic peptide (NP) gene expression in deoxycorticosterone acetate (DOCA)-salt hypertension. In this model, stimulation of the cardiac natriuretic peptide (NP) and the endothelin system and suppression of the renin-angiotensin system is observed. DOCA-salt induced significant hypertension, cardiac hypertrophy and increased NP plasma and left atrial and right and left ventricular NP gene expression. ETB blockade per se produced hypertension and left ventricular hypertrophy but induced little change on the levels of ventricular NP and only increased left atrial natriuretic factor (ANF) mRNA levels. Combined ETBblockade/DOCA-salt treatment worsened hypertension, increased left ventricular hypertrophy and induced right ventricular hypertrophy. All animals so treated had increased ventricular NP gene expression. Collagen III and β-myosin heavy chain gene expression were enhanced in both the right and the left ventricle of DOCA-salt hypertensive rats. The results of this study suggest that the ETBreceptor does not participate directly in the modulation of atrial or ventricular NP gene expression and that this receptor mediates a protective cardiovascular function. ETB blockade can induce significant ventricular hypertrophy without an increase in ANF or brain NP gene expression.

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5029Obese hypertensive men have lower circulating proatrial natriuretic peptide concentrations despite greater left atrial size

European Heart Journal ◽

10.1093/eurheartj/ehx493.5029 ◽

2017 ◽

Vol 38 (suppl_1) ◽

Author(s):

C.L. Asferg ◽

U.B. Andersen ◽

A. Linneberg ◽

J.P. Goetze ◽

J.L. Jeppesen

Keyword(s):

Natriuretic Peptide ◽

Left Atrial ◽

Left Atrial Size ◽

Atrial Size

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2140Association of arterial stiffness with left atrial structure and phasic function: a community-based cohort study

European Heart Journal ◽

10.1093/eurheartj/ehz748.0087 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

Y Yoshida ◽

K Nakanishi ◽

M Daimon ◽

J Ishiwata ◽

N Sawada ◽

...

Keyword(s):

Atrial Fibrillation ◽

Cardiovascular Disease ◽

Arterial Stiffness ◽

Left Atrial ◽

Global Longitudinal Strain ◽

Multivariable Analysis ◽

Significant Risk ◽

Left Ventricular ◽

Volume Index ◽

Community Based

Abstract Background Increased arterial stiffness is recognized as an independent risk factor for atrial fibrillation, although the pathophysiological mechanisms remain unclear. Cardio-ankle vascular index (CAVI) is emerging as an important tool to assess arterial stiffness noninvasively which is derived from the concept of stiffness β index and is less dependent on blood pressure at the time of measurement than pulse wave velocity. Purpose This study aimed to investigate the association of arterial stiffness with left atrial (LA) volume and phasic function in a community-based cohort. Methods We included 1,156 participants without overt cardiovascular disease who underwent extensive cardiovascular examination. Arterial stiffness was evaluated by CAVI. Speckle-tracking echocardiography was employed to evaluate LA phasic function including reservoir, conduit and pump strain as well as left ventricular global longitudinal strain (LVGLS). Results CAVI was negatively correlated with reservoir and conduit strain (r=−0.37 and −0.45, both p<0.001; Figure), whereas weakly, but positively correlated with LA volume index and pump strain (r=0.12 and 0.09, both p<0.01). In multivariable analysis, CAVI was significantly associated with reservoir and conduit strain independent of traditional cardiovascular risk factors, pertinent laboratory parameters and LV morphology and function including LVGLS (standardized β=−0.22 and −0.26, respectively, both p<0.001), whereas there was no independent association with LA volume index and pump strain. In the categorical analysis, the abnormal CAVI (≥9.0) carried the significant risk of impaired reservoir (<31.4%) and conduit (<12.4%) strain (adjusted odds ratio = 2.63 and 3.71 vs. normal CAVI, both p<0.01) in a fully-adjusted model including laboratory and echocardiographic parameters. Figure 1 Conclusion Arterial stiffness was independently associated with LA reservoir and conduit function, even in the absence of overt cardiovascular disease. This association may explain the higher incidence of atrial fibrillation in individuals with increased arterial stiffness.

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