The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway

2019 ◽  
Vol 35 (6) ◽  
pp. 521-539 ◽  
Author(s):  
Yu-Long Lan ◽  
Yu-Jie Zou ◽  
Jia-Cheng Lou ◽  
Jin-Shan Xing ◽  
Xun Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Sodium Pump ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
P53 Signaling ◽  
Human Glioblastoma Cells ◽  
P53 Signaling Pathway ◽  
Α1 Subunit

scholarly journals RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1244
Author(s):  
Min Yu ◽  
Xiaoyan Hu ◽  
Jingyu Yan ◽  
Ying Wang ◽  
Fei Lu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Signaling Pathway ◽  
Cyclin E ◽  
Intraperitoneal Administration ◽  
Glioblastoma Cells ◽  
P53 Signaling ◽  
Cycle Arrest ◽  
P53 Signaling Pathway

Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown to significantly inhibit the proliferation of prostate cancer cells by targeting the atypical protein kinase RIOK2. It is documented that RIOK2 overexpressed in glioblastoma. However, whether NSC139021 can inhibit the growth of glioblastoma cells and be a potential drug for glioblastoma treatment need to be clarified. In this study, we investigated the effects of NSC139021 on human U118MG, LN-18, and mouse GL261 glioblastoma cells and the mouse models of glioblastoma. We verified that NSC139021 effectively inhibited glioblastoma cells proliferation, but it is independent of RIOK2. Our data showed that NSC139021 induced cell cycle arrest at G0/G1 phase via the Skp2-p27/p21-Cyclin E/CDK2-pRb signaling pathway in G1/S checkpoint regulation. In addition, NSC139021 also increased the apoptosis of glioblastoma cells by activating the p53 signaling pathway and increasing the levels of Bax and cleaved caspase 3. Furthermore, intraperitoneal administration of 150 mg/kg NSC139021 significantly suppressed the growth of human and mouse glioblastoma in vivo. Our study suggests that NSC139021 may be a potential chemotherapy drug for the treatment of glioblastoma by targeting the Skp2-p27/p21-Cyclin E/CDK2-pRb signaling pathway.

Response of sodium pump to ouabain challenge in human glioblastoma cells in culture

2009 ◽  
Vol 10 (4-3) ◽  
pp. 884-892 ◽  
Author(s):  
Xian Huang ◽  
Zhenmin Lei ◽  
Xiao-Ping Li ◽  
Rif S. El-Mallakh
Keyword(s):  
Sodium Pump ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Cells In Culture ◽  
Human Glioblastoma Cells

GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway

2019 ◽  
Vol 1717 ◽  
pp. 117-126 ◽  
Author(s):  
Xiang Ding ◽  
Gang Deng ◽  
Junhui Liu ◽  
Baohui Liu ◽  
Fan'en Yuan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway

2021 ◽  
Vol 14 ◽  
Author(s):  
Yiyun Liu ◽  
Yangsheng Chen ◽  
Ruihong Zhu ◽  
Li Xu ◽  
Heidi Qunhui Xie ◽  
...  
Keyword(s):  
Cell Migration ◽  
Aryl Hydrocarbon Receptor ◽  
Signaling Pathway ◽  
Dependent Manner ◽  
Glioblastoma Cell ◽  
Glioblastoma Cells ◽  
Migration Ability ◽  
Human Glioblastoma ◽  
Aryl Hydrocarbon ◽  
Human Glioblastoma Cells

Glioblastoma is the most frequent and aggressive primary astrocytoma in adults. The high migration ability of the tumor cells is an important reason for the high recurrence rate and poor prognosis of glioblastoma. Recently, emerging evidence has shown that the migration ability of glioblastoma cells was inhibited upon the activation of aryl hydrocarbon receptor (AhR), suggesting potential anti-tumor effects of AhR agonists. Rutaecarpine is a natural compound with potential tumor therapeutic effects which can possibly bind to AhR. However, its effect on the migration of glioblastoma is unclear. Therefore, we aim to explore the effects of rutaecarpine on the migration of human glioblastoma cells U87 and the involvement of the AhR signaling pathway. The results showed that: (i) compared with other structural related alkaloids, like evodiamine and dehydroevodiamine, rutaecarpine was a more potent AhR activator, and has a stronger inhibitory effect on the glioblastoma cell migration; (ii) rutaecarpine decreased the migration ability of U87 cells in an AhR-dependent manner; (iii) AhR mediated the expression of a tumor suppressor interleukin 24 (IL24) induced by rutaecarpine, and AhR-IL24 axis was involved in the anti-migratory effects of rutaecarpine on the glioblastoma. Besides IL24, other candidates AhR downstream genes both associated with cancer and migration were proposed to participate in the migration regulation of rutaecarpine by RNA-Seq and bioinformatic analysis. These data indicate that rutaecarpine is a naturally-derived AhR agonist that could inhibit the migration of U87 human glioblastoma cells mostly via the AhR-IL24 axis.

Bex2 Controls Proliferation of Human Glioblastoma Cells Through NF-κB Signaling Pathway

2014 ◽  
Vol 53 (2) ◽  
pp. 262-270 ◽  
Author(s):  
Qingming Meng ◽  
Tongle Zhi ◽  
Yuewen Chao ◽  
Er Nie ◽  
Xuebin Xu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells
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