Poly ɛ-caprolactone/nanostarch composite nanofibrous wound dressing with antibacterial property and pH stimulus drug release

Cellulose ◽  
2021 ◽  
Author(s):  
C. R. Reshmi ◽  
P. Sagitha ◽  
Sheeja ◽  
A. Sujith
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Antibacterial Property

Porous SBA-15/cellulose membrane with prolonged anti-microbial drug release characteristics for potential wound dressing application

Cellulose ◽  
2020 ◽  
Vol 27 (5) ◽  
pp. 2737-2756
Author(s):  
Zhi Shen ◽  
Ning Cai ◽  
Yanan Xue ◽  
Bo Yu ◽  
Jianzhi Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Cellulose Membrane

Shape memory polyacrylamide/gelatin hydrogel with controllable mechanical and drug release properties potential for wound dressing application

Polymer ◽  
2021 ◽  
pp. 123786
Author(s):  
Weiwei Fan ◽  
Zetian Zhang ◽  
Yang Liu ◽  
Junchao Wang ◽  
Zhengjun Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Shape Memory ◽  
Wound Dressing ◽  
Gelatin Hydrogel

Mussel-inspired adhesive gelatin–polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration

Soft Matter ◽  
2022 ◽  
Author(s):  
Yamei Wang ◽  
Dongdong Xiao ◽  
Lin Quan ◽  
Hongbin Chai ◽  
Xiaofeng Sui ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Wound Dressing ◽  
Antibacterial Property ◽  
Wound Care ◽  
Skin Regeneration ◽  
Tetracycline Hydrochloride ◽  
Market Size ◽  
Good Mechanical Property ◽  
Polyacrylamide Hydrogel

Even though the global wound care market size was valued at USD 19.83 billion in 2020, it is still a challenge to develop a hydrogel-based wound dressing with a good mechanical property, adhesiveness and antibacterial property.

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

2021 ◽  
Vol 36 (5) ◽  
pp. 431-443
Author(s):  
Swetha Andra ◽  
Satheesh kumar Balu ◽  
Rajalakshmi Ramamoorthy ◽  
Murugesan Muthalagu ◽  
Devisri Sampath ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Dressing ◽  
High Surface ◽  
High Surface Area ◽  
Antimicrobial Properties ◽  
Sustained Drug Release ◽  
Gram Positive Bacteria ◽  
Antimicrobial Efficiency ◽  
Cissus Quadrangularis

Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.

Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing

2020 ◽  
Vol 3 (10) ◽  
pp. 7219-7227
Author(s):  
Ho Ying Huang ◽  
Artiom Skripka ◽  
Liana Zaroubi ◽  
Brandon L. Findlay ◽  
Fiorenzo Vetrone ◽  
...  
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Controlled Drug Release ◽  
Nir Light

Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application

2014 ◽  
Vol 122 ◽  
pp. 175-183 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Shalini Rajkumar ◽  
Hari C. Bajaj ◽  
Shiva Shankaran Chettiar ◽  
Kalpeshgiri Gosai ◽  
...  
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Controlled Drug Release ◽  
Composite Hydrogels

A photo-cleavable polyprodrug-loaded wound dressing with UV-responsive antibacterial property

2017 ◽  
Vol 5 (45) ◽  
pp. 8975-8982 ◽  
Author(s):  
Qian Pang ◽  
Xiaowen Zheng ◽  
Yu Luo ◽  
Lie Ma ◽  
Changyou Gao
Keyword(s):  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Antibacterial Property ◽  
Poly Vinyl Alcohol

A wound dressing with UV-responsive antibacterial property was prepared by loading a photo-cleavable polyprodrug (LHP) into poly(vinyl alcohol)/sodium alginate (PVA/SA) wound dressing to overcome the overuse of antibiotics.

scholarly journals Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Woan Sean Tan ◽  
Palanisamy Arulselvan ◽  
Shiow-Fern Ng ◽  
Che Norma Mat Taib ◽  
Murni Nazira Sarian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Dressing ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Dermal Fibroblast ◽  
Wound Dressings ◽  
Dependent Manner ◽  
Synthetic Compound ◽  
Study Results

Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

Study of thermal-sensitive alginate-Ca2+/poly(N-isopropylacrylamide) hydrogels supported by cotton fabric for wound dressing applications

2018 ◽  
Vol 89 (5) ◽  
pp. 801-813 ◽  
Author(s):  
Bing Li ◽  
Dapeng Li ◽  
Yanni Yang ◽  
Lu Zhang ◽  
Ke Xu ◽  
...  
Keyword(s):  
Water Vapor ◽  
Drug Release ◽  
Cotton Fabric ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Cotton Fabrics ◽  
Solution Temperature ◽  
Scanning Calorimetry ◽  
Direct Deposition ◽  
Fabric Surface

In this study, direct deposition, 1,2,3,4-butanetetracarboxylic acid (BTCA) crosslinking, chelating and ultraviolet (UV) photo-grafting methods were employed to bond alginate-Ca2+/poly( N-isopropylacrylamide) (PNIPAAm) interpenetrating network hydrogel onto cotton fabric surface for wound dressing applications. Infrared spectroscopy confirmed the presence of alginate-Ca2+/PNIPAAm hydrogels on the cotton fabrics. Scanning electron microscopy was used to investigate surface and cross-section morphologies. Differential scanning calorimetry and three-dimensional video microscopy indicated that fabric-supported hydrogels maintained the thermal-sensitive property with a lower critical solution temperature (LCST) of around 34–35℃. The results of water vapor permeation revealed that the water vapor transmission rate at 37℃ was significantly higher than that at 25℃ for the shrink and collapse of the hydrogels above the LCST. Moreover, the breaking stress of the fabric-supported hydrogels was similar to that of the original cotton fabrics, but much larger than the hydrogels by themselves. The UV photo-grafting provided the strongest peel strength, followed by the BTCA crosslinking, the chelating and the direct deposition method. The cotton fabric-supported alginate-Ca2+/PNIPAAm hydrogels were stiffer than the original cotton fabric due to the high glass transition temperature of PNIPAAm (about 140℃). The in vitro drug release experiment confirmed that the cumulative release amount was much higher at around 37℃ (above the LCST) than at 25℃ (below the LCST). This showed that the fabric-supported thermal-sensitive hydrogels had functions of keeping the wound area breathable and comfortable, and provided controlled drug release with good mechanical properties, indicating a great potential and significance for wound dressing applications.

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