Mussel-inspired adhesive gelatin–polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration

Even though the global wound care market size was valued at USD 19.83 billion in 2020, it is still a challenge to develop a hydrogel-based wound dressing with a good mechanical property, adhesiveness and antibacterial property.

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Preparation and Characterization of Silk Fibroin Based Antibacterial Biotextiles as Wound Dressing

Materials Science Forum ◽

10.4028/www.scientific.net/msf.898.2095 ◽

2017 ◽

Vol 898 ◽

pp. 2095-2100 ◽

Cited By ~ 1

Author(s):

Zhi Hua Lu ◽

Dong Mei Zhao ◽

Cheng Shun Li

Keyword(s):

Thin Film ◽

Wound Healing ◽

Porous Structure ◽

Silk Fibroin ◽

Wound Dressing ◽

Antibacterial Property ◽

Chitosan Solution ◽

Skin Regeneration ◽

Sem Micrographs

A novel silk fibroin (SF) based bi-layered wound dressing was successfully developed by spraying chitosan (CS) solution on the ring spun silk fibroin fabric. SEM micrographs showed that chitosan solution formed a thin film on the degummed silk fibroin fabric, which had a connective porous structure. The antibacterial property, indirect cytotoxicity and the wound healing properties of the materials were investigated. Comparing with the commercial wound dressing, the bi-layered SF/CS wound dressing could accelerate the wound healing, and may be a potential choice for skin regeneration.

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Self-healing poly(siloxane-urethane) elastomers with remoldability, shape memory and biocompatibility

Polymer Chemistry ◽

10.1039/c6py01499b ◽

2016 ◽

Vol 7 (47) ◽

pp. 7278-7286 ◽

Cited By ~ 63

Author(s):

Jian Zhao ◽

Rui Xu ◽

Gaoxing Luo ◽

Jun Wu ◽

Hesheng Xia

Keyword(s):

Mechanical Property ◽

Shape Memory ◽

Microphase Separation ◽

Diels Alder ◽

Good Mechanical Property ◽

Self Healing ◽

Healing Efficiency ◽

Good Biocompatibility

The poly(siloxane-urethane) elastomers with microphase separation structure and Diels–Alder bonds show high healing efficiency, good mechanical property and good biocompatibility.

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Radiation sterilization of Honey and Honey-Alginate Wound Dressing from Stingless Bee (Tetragonula biroi) Collected from Sta. Maria, Laguna, Philippines

Journal of Tropical Life Science ◽

10.11594/jtls.11.02.11 ◽

2021 ◽

Vol 11 (2) ◽

pp. 217-223

Author(s):

Davison Baldos ◽

◽

Joseph Puno ◽

Levelyn Tolentino ◽

Djowel Montefalcon ◽

...

Keyword(s):

Electron Beam ◽

Physicochemical Properties ◽

Wound Dressing ◽

Transmission Rate ◽

Wound Care ◽

Stingless Bee ◽

Soluble Solids ◽

Radiation Sterilization ◽

Fluid Handling ◽

Potential Use

This study was conducted to determine the effect of radiation sterilization on alginate wound dressing containing honey from the Philippine stingless bee, Tetragonula biroi. Our results show that a radiation dose of 30 kGy did not affect the antibacterial property of honey against Staphylococcus aureus. Electron-beam irradiation did not produce significant alterations in the physicochemical properties (pH, total soluble solids, and flavonoids); however, the total phenolics was significantly increased in honey with higher irradiation doses. Demonstrating that irradiation can be applied to honey with negligible physicochemical effects, honey was incorporated in alginate and exposed to a sterilization dose of 25 kGy using an electron beam facility. Irradiation did not affect the physicochemical properties (pH, moisture content, gel fraction, moisture vapor transmission rate (MVTR), and fluid handling capacity) of the honey alginate wound dressing (HAWD). The perspectives for the potential use of irradiated HAWD as a natural product-based substitute for commercial wound care products may be considered.

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Sintesis Hidrogel Pektin – Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar

Jurnal Teknik Kimia dan Lingkungan ◽

10.33795/jtkl.v4i1.128 ◽

2020 ◽

Vol 4 (1) ◽

pp. 53

Author(s):

Fadhil Muhammad Tarmidzi ◽

Inggit Kresna Maharsih ◽

Tina Raihatul Jannah ◽

Cici Sari Wahyuni

Keyword(s):

Mechanical Properties ◽

Tensile Strength ◽

Citric Acid ◽

Wound Dressing ◽

Wound Care ◽

Crosslinking Agent ◽

Wound Dressings ◽

Esterification Reaction ◽

Natural Polymers ◽

Fruit Peel

Teknik pembalutan luka saat ini menerapkan metode perawatan luka modern dengan cara mempertahankan isolasi lingkungan luka dalam keadaan tertutup dan lembab. Ada beberapa jenis pembalut luka yang telah dikembangkan, salah satunya hidrogel. Hidrogel merupakan pembalut luka berbentuk lembaran yang memiliki kemampuan menyerap cairan luka dan memiliki stabilitas yang baik pada pH asam sehingga dapat digunakan untuk pengobatan luka bakar. Dalam penelitian ini, hidrogel dibuat menggunakan polimer alami seperti pektin dan gelatin. Kedua bahan tersebut dikombinasikan menggunakan metode ikatan silang dengan penambahan asam sitrat sebagai agen pengikat silang. Penambahan asam sitrat memberikan pengaruh terhadap karakteristik material hidrogel yang dihasilkan, sehingga diperlukan jumlah yang tepat agar didapatkan hidrogel dengan properti material yang baik. Hidrogel juga ditambahkan zat aktif berupa flavonoid pada ekstrak kulit buah naga agar dapat digunakan sebagai pembalut luka untuk menyembuhkan luka bakar. Dari hasil penelitian, hidrogel dengan konsentrasi asam sitrat 4% (Hidrogel CA 4%) menghasilkan nilai swelling, tensile strength, dan elongation tertinggi sebesar 890%, 0,05 Mpa, dan 200%. Hasil properti mekanik dari Hidrogel CA 4% ini dibuktikan dengan uji FTIR yang telah dilakukan, yaitu munculnya gugus karbonil C=O sebagai hasil reaksi esterifikasi yang terjadi antara polimer dengan asam sitrat di daerah serapan 1733,9 cm-1.Wound dressing technique currently applies modern wound care methods by maintaining the environmental isolation of the wound in a closed and moist state. There are several types of wound dressing that have been developed, one of them is hydrogel. Hydrogel is sheet-shaped wound dressings which have the ability to absorb exudate and have good stability acidic pH that can be used for the treatment of burns. In this study, hydrogel were made using natural polymers such as pectin and gelatin. The two polymers were combined using crosslinking method with the addition of citric acid as a crosslinking agent. The addition of citric acid has affect on the characteristics of the hydrogel material produced, therefore the right amount is needed to obtain a hydrogel with good mechanical properties. Hydrogel also added by an active substance in the form of flavonoids from dragon fruit peel extract that can be used as a wound dressing to cure burns. This study resulting hydrogel with a concentration of 4% citric acid (Hydrogel CA 4%) produced highest value of swelling, tensile strength, and elongation are 890%, 0.05 Mpa, and 200%, repectively. The mechanical properties of Hydrogel CA 4% was proved by FTIR test that had been carried out, namely the presence of C=O carbonyl group as a result of the esterification reaction that occurred between the polymers and citric acid in the absorption area of 1733.9 cm-1.

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Development of a poly(arylene sulfide sulfone) antibacterial electrospun film as a skin wound dressing application

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545822500079 ◽

2021 ◽

Author(s):

Xuzhi Lang ◽

Zhurong Tang ◽

Zhimei Wei ◽

Xiaojun Wang ◽

Shengru Long ◽

...

Keyword(s):

Mechanical Property ◽

Zno Nanoparticles ◽

Wound Dressing ◽

Skin Wound ◽

Dead Cell ◽

Skin Wound Healing ◽

High Mechanical Property ◽

Water Contact ◽

Transmission Electron ◽

Dispersion Solution

Tissue engineering has become a hot issue for skin wound healing because it can be used as an alternative treatment to traditional grafts. Nanofibrous films have been widely used due to their excellent properties. In this work, an organic/inorganic composite poly(arylene sulfide sulfone)/ZnO/graphene oxide (PASS/ZnO/GO) nanofibrous film was fabricated with the ZnO nanoparticles blending in an electrospun solution and post-treated with the GO deposition. The optimal PASS/ZnO/GO nanofibrous film was prepared by 2% ZnO nanoparticles, 3.0[Formula: see text]g/mL PASS electrospun solution, and 1% GO dispersion solution. The morphology, hydrophilicity, mechanical property, and cytotoxicity of the PASS/ZnO/GO nanofibrous film were characterized by using scanning electron microscopy, transmission electron microscope, water contact angle, tensile testing, and a Live/Dead cell staining kit. It is founded that the PASS/ZnO/GO nanofibrous film has outstanding mechanical properties and no cytotoxicity. Furthermore, the PASS/ZnO/GO nanofibrous film exhibits excellent antibacterial activity to both Escherichia coli and Staphylococcus aureus. Above all, this high mechanical property in the non-toxic and antibacterial nanofibrous film will have excellent application prospects in skin wound dressing.

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Synthesis of Polyvinyl Formal Sponge for Wound Care Dressing Application

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.152-153.1650 ◽

2010 ◽

Vol 152-153 ◽

pp. 1650-1659

Author(s):

Qing Hao Yang ◽

Guang Xu Cheng ◽

Zhi Cheng Zhang

Keyword(s):

Mechanical Properties ◽

Mechanical Strength ◽

Porous Structure ◽

Pore Structure ◽

Water Absorption ◽

Wound Dressing ◽

Wound Care ◽

Acid Catalyst ◽

The Other ◽

Polyvinyl Formal

In an effort to seek poly(vinyl formal) (PVFM) foams based wound dressing pad material, a series of foamed PVFM materials have been synthesized under varied conditions. The influence of conditions on the properties of PVFM foam, such as mechanical properties, water absorption, pore structure and bulk density, is well discussed individually. It has been shown that both the reactant and acid catalyst affect the degree and speed of acetalization, therefore the mechanical properties, pores continuity and water absorption of the resultant sample. The addition of Na2CO3, surfactant and CMCNa are mainly influencing the porous structure as well as the mechanical properties and water absorption. One best sample with balanced properties is obtained. It possesses higher mechanical strength and water absorption while the other properties are similar, comparing with a commercial surgical PVFM sponge (YJ-1) currently used.

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Gauze Packing of Open Surgical Wounds: Empirical or Evidence-Based Practice?

Annals of The Royal College of Surgeons of England ◽

10.1308/003588406x83014 ◽

2006 ◽

Vol 88 (1) ◽

pp. 33-36 ◽

Cited By ~ 19

Author(s):

F Dinah ◽

A Adhikari

Keyword(s):

Wound Dressing ◽

Long Term Care ◽

Wound Care ◽

Operating Theatre ◽

Evidence Based ◽

Term Care ◽

Community Or ◽

Secondary Intention ◽

Surgical Wounds

INTRODUCTION Most surgical wounds are closed primarily, but some are allowed to heal by secondary intention. This usually involves repeated packing and dressing of the raw wound surfaces. Although the long-term care of such wounds has devolved to the care of nurses in the community or out-patient setting, the initial wound dressing or cavity packing is done by the surgeon in the operating theatre. Many surgeons are unaware of the growth of the discipline of wound care, and still use traditional soaked gauze for dressing and packing open surgical wounds and cavities. RESULTS This review summarises the some of the modern alternatives available and the evidence – or the lack of it – for their use in both the acute and chronic setting.

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Design and Construction Analysis of Cement-Stabilized Macadam Foundation

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.340.80 ◽

2013 ◽

Vol 340 ◽

pp. 80-84

Author(s):

Deng Lin

Keyword(s):

Mechanical Property ◽

Frost Resistance ◽

Water Stability ◽

Good Mechanical Property ◽

Control Methods ◽

Mechanical Theory ◽

Cement Stabilization ◽

Base Course ◽

Pavement Base ◽

Design And Construction

Cement-stabilized macadam has good mechanical property, but also has the advantages of plate nature, water stability and frost resistance, and it is widely used in the pavement base or sub-base course of expressway. Based on the fundamental mechanical theory of the strength and the global stability of cement stabilization macadam, this article discusses how to design the grading of the cement stabilization macadam and the influencing factors, besides, it also presents the construction control methods of the cement stabilization macadam, which is of guiding significance to the design and construction of the cement stabilization macadam.

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The ‘transverse guard’ wound dressing technique to reduce faecal contamination after spinal surgery in neonates and infants

British Journal of Nursing ◽

10.12968/bjon.2020.29.12.s12 ◽

2020 ◽

Vol 29 (12) ◽

pp. S12-S15

Author(s):

William B Lo ◽

Katie Herbert ◽

Desiderio Rodrigues ◽

Fardad T Afshari

Keyword(s):

Spinal Surgery ◽

Wound Dressing ◽

Simple Technique ◽

Wound Care ◽

Infection Rates ◽

Perianal Area ◽

Natal Cleft ◽

Faecal Material ◽

Faecal Contamination ◽

Neonates And Infants

Wound care following lower spinal surgery in infants, especially open lumbosacral myelomeningocele (MMC) repair is challenging for a number of reasons: the babies' small size, uneven contour of the natal cleft, proximity of the wound to the perianal area, continuous soiling by loose/poorly-formed stool, and fragile skin. Faecal contamination of the wound can lead to infection, ascending meningitis and further morbidity. A single adhesive dressing does not reliably obliterate the space in the natal cleft and, therefore, does not prevent faecal material tracking rostrally underneath the dressing. This increases the risk of contamination and necessitates frequent wound dressing changes. The authors describe the use of the ‘transverse guard’, a simple technique routinely used in their unit that help overcome these problems. They also report on the wound infection rates of neonates undergoing open MMC repair who had the new dressings versus those who had conventional dressings.

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