Porous SBA-15/cellulose membrane with prolonged anti-microbial drug release characteristics for potential wound dressing application

Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.

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Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing

ACS Applied Bio Materials ◽

10.1021/acsabm.0c01019 ◽

2020 ◽

Vol 3 (10) ◽

pp. 7219-7227

Author(s):

Ho Ying Huang ◽

Artiom Skripka ◽

Liana Zaroubi ◽

Brandon L. Findlay ◽

Fiorenzo Vetrone ◽

...

Keyword(s):

Drug Release ◽

Wound Dressing ◽

Controlled Drug Release ◽

Nir Light

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Poly(vinyl alcohol) Hydrogel/Chitosan-Modified Clay Nanocomposites for Wound Dressing Application and Controlled Drug Release

Macromolecular Research ◽

10.1007/s13233-019-7046-z ◽

2019 ◽

Vol 27 (3) ◽

pp. 290-300 ◽

Cited By ~ 6

Author(s):

Samira Feiz ◽

Amir H. Navarchian

Keyword(s):

Drug Release ◽

Vinyl Alcohol ◽

Wound Dressing ◽

Controlled Drug Release ◽

Poly Vinyl Alcohol ◽

Clay Nanocomposites ◽

Modified Clay

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Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2014.06.051 ◽

2014 ◽

Vol 122 ◽

pp. 175-183 ◽

Cited By ~ 68

Author(s):

Bhavesh D. Kevadiya ◽

Shalini Rajkumar ◽

Hari C. Bajaj ◽

Shiva Shankaran Chettiar ◽

Kalpeshgiri Gosai ◽

...

Keyword(s):

Drug Release ◽

Wound Dressing ◽

Controlled Drug Release ◽

Composite Hydrogels

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Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

Materials ◽

10.3390/ma14237266 ◽

2021 ◽

Vol 14 (23) ◽

pp. 7266

Author(s):

Kamil P. Grela ◽

Dominik M. Marciniak ◽

Bożena Karolewicz

Keyword(s):

Controlled Release ◽

Drug Release ◽

Castor Oil ◽

Oil Content ◽

Poloxamer 407 ◽

Isopropyl Myristate ◽

Cellulose Membrane ◽

Oil In Water ◽

Injection Force ◽

Novel Drug

This article covers the design and evaluation of a novel drug vehicle: a thermosensitive, injectable, high-oil-content (50% w/w) emulgel providing a controlled release of lipophilic pharmaceuticals. Different vegetable (castor, canola, olive, peanut, grapeseed, linseed), mineral (paraffin) and semisynthetic (isopropyl myristate, oleic acid) oils were screened for ibuprofen (IBU) solubility and for their capacity for high-shear emulsification in a 17% (w/w) aqueous solution of poloxamer 407. Chosen emulgels were subject to a rheological evaluation, a syringeability test (TA.XT texture analyser; 2 mL syringe; 18 G, 20 G and 22 G needles) and a drug release study (48 h; cellulose membrane; 0.05 mol/L phosphate buffer at pH 7.4). Castor oil turned out to be an optimal component for IBU incorporation. Blank and drug-loaded castor oil emulgels were susceptible to administration via a syringe and needle, with the absolute injection force not exceeding 3 kg (29.4 N). The drug release test revealed dose-dependent, quasi-linear kinetics, with up to 44 h of controlled, steady, linear release. The results indicate the significant potential of high-oil-content, oil-in-water thermosensitive emulgel formulations as vehicles for the controlled release of lipophilic APIs.

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Engineering Sustainable Antimicrobial Release in Silica-Cellulose Membrane with CaCO3-Aided Processing for Wound Dressing Application

Polymers ◽

10.3390/polym11050808 ◽

2019 ◽

Vol 11 (5) ◽

pp. 808 ◽

Cited By ~ 3

Author(s):

Zhi Shen ◽

Ning Cai ◽

Yanan Xue ◽

Vincent Chan ◽

Bo Yu ◽

...

Keyword(s):

Sustained Release ◽

Wound Dressing ◽

Drug Loading ◽

Composite Membranes ◽

Antibacterial Activities ◽

Wound Dressings ◽

Alkaline Condition ◽

Vapor Permeability ◽

Cellulose Membrane ◽

Swelling Properties

The sustained release of antimicrobial therapeutics for wound dressing has become an attractive design strategy for prolonging the timespan of wound dressings and for reducing the risk of chronic wound infection. Recently, cellulose-based membrane has become a preferred option of wound dressings for the treatment of burn wounds and skin ulcers. In this work, novel cellulose membrane incorporated with mesoporous silica particles (SBA-15) was developed as an antimicrobial wound dressing with desirable sustained release functionality for targeting persistent bacterial pathogens. Attributed to a coated layer of calcium carbonate (CaCO3), SBA-15 particles were free from corrosion in alkaline condition during the preparation of cellulose-based composite membranes. SEM, TEM and BET results showed that the morphology, specific surface area, pore size and pore volume of pristine SBA-15 were preserved after the incorporation of CaCO3-coated SBA-15 into the cellulose matrix, while the mesoporous structure of SBA-15 was significantly disrupted without the use of CaCO3 coating. The resultant composite membranes containing 30 wt% SBA-15 (denoted as CM-Ca2-SBA(30%)) achieved 3.6 wt% of antimicrobial drug loading. Interestingly, CM-Ca2-SBA(30%) demonstrated the sustained release property of chloramphenicol for 270 h, driven by a two-stage drug release processes of SBA-15/cellulose. The water vapor permeability (WVTR) and swelling properties of composite membranes were shown to have complied with the primary requirements of wound dressing. Antibacterial assays revealed that strong antibacterial activities (144 h) of the composite membranes against Staphylococcus aureus and Eschericia coli were achieved. All results displayed that the strategy of coating silica with CaCO3 helps to obtain cellulose–silica composite membranes with desirable sustained release profiles and strong antibacterial activities. The antibacterial SBA-15/cellulose composite membranes show potential for the application of wound dressing.

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Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

BioMed Research International ◽

10.1155/2020/4730858 ◽

2020 ◽

Vol 2020 ◽

pp. 1-15

Author(s):

Woan Sean Tan ◽

Palanisamy Arulselvan ◽

Shiow-Fern Ng ◽

Che Norma Mat Taib ◽

Murni Nazira Sarian ◽

...

Keyword(s):

Wound Healing ◽

Drug Release ◽

Wound Dressing ◽

Wound Repair ◽

Chronic Wounds ◽

Dermal Fibroblast ◽

Wound Dressings ◽

Dependent Manner ◽

Synthetic Compound ◽

Study Results

Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

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Poly ɛ-caprolactone/nanostarch composite nanofibrous wound dressing with antibacterial property and pH stimulus drug release

Cellulose ◽

10.1007/s10570-021-04287-7 ◽

2021 ◽

Author(s):

C. R. Reshmi ◽

P. Sagitha ◽

Sheeja ◽

A. Sujith

Keyword(s):

Drug Release ◽

Wound Dressing ◽

Antibacterial Property

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Study of thermal-sensitive alginate-Ca2+/poly(N-isopropylacrylamide) hydrogels supported by cotton fabric for wound dressing applications

Textile Research Journal ◽

10.1177/0040517518755790 ◽

2018 ◽

Vol 89 (5) ◽

pp. 801-813 ◽

Cited By ~ 5

Author(s):

Bing Li ◽

Dapeng Li ◽

Yanni Yang ◽

Lu Zhang ◽

Ke Xu ◽

...

Keyword(s):

Water Vapor ◽

Drug Release ◽

Cotton Fabric ◽

Wound Dressing ◽

Transmission Rate ◽

Cotton Fabrics ◽

Solution Temperature ◽

Scanning Calorimetry ◽

Direct Deposition ◽

Fabric Surface

In this study, direct deposition, 1,2,3,4-butanetetracarboxylic acid (BTCA) crosslinking, chelating and ultraviolet (UV) photo-grafting methods were employed to bond alginate-Ca2+/poly( N-isopropylacrylamide) (PNIPAAm) interpenetrating network hydrogel onto cotton fabric surface for wound dressing applications. Infrared spectroscopy confirmed the presence of alginate-Ca2+/PNIPAAm hydrogels on the cotton fabrics. Scanning electron microscopy was used to investigate surface and cross-section morphologies. Differential scanning calorimetry and three-dimensional video microscopy indicated that fabric-supported hydrogels maintained the thermal-sensitive property with a lower critical solution temperature (LCST) of around 34–35℃. The results of water vapor permeation revealed that the water vapor transmission rate at 37℃ was significantly higher than that at 25℃ for the shrink and collapse of the hydrogels above the LCST. Moreover, the breaking stress of the fabric-supported hydrogels was similar to that of the original cotton fabrics, but much larger than the hydrogels by themselves. The UV photo-grafting provided the strongest peel strength, followed by the BTCA crosslinking, the chelating and the direct deposition method. The cotton fabric-supported alginate-Ca2+/PNIPAAm hydrogels were stiffer than the original cotton fabric due to the high glass transition temperature of PNIPAAm (about 140℃). The in vitro drug release experiment confirmed that the cumulative release amount was much higher at around 37℃ (above the LCST) than at 25℃ (below the LCST). This showed that the fabric-supported thermal-sensitive hydrogels had functions of keeping the wound area breathable and comfortable, and provided controlled drug release with good mechanical properties, indicating a great potential and significance for wound dressing applications.

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