Effects of the Methanolic Extract of Vitellaria paradoxa Stem Bark Against Scopolamine-Induced Cognitive Dysfunction and Oxidative Stress in the Rat Hippocampus

2015 ◽  
Vol 36 (7) ◽  
pp. 1139-1149 ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Acha Emmanuel Asongalem ◽  
Eyong Kenneth Oben ◽  
Oana Cioanca ◽  
Monica Hancianu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Dysfunction ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Rat Hippocampus ◽  
Vitellaria Paradoxa ◽  
And Oxidative Stress

scholarly journals Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer’s Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Nesrine S. El Sayed ◽  
Mamdooh H. Ghoneum
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Protective Effect ◽  
Cognitive Dysfunction ◽  
Protective Role ◽  
Sporadic Alzheimer’S Disease ◽  
Stat3 Pathway ◽  
And Oxidative Stress

Background. Many neurodegenerative diseases such as Alzheimer’s disease are associated with oxidative stress. Therefore, antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases. Objective. We investigated the ability of the antioxidant Antia to exert a protective effect against sporadic Alzheimer’s disease (SAD) induced in mice. Antia is a natural product that is extracted from the edible yamabushitake mushroom, the gotsukora and kothala himbutu plants, diosgenin (an extract from wild yam tubers), and amla (Indian gooseberry) after treatment with MRN-100. Methods. Single intracerebroventricular (ICV) injection of streptozotocin (STZ) (3 mg/kg) was used for induction of SAD in mice. Antia was injected intraperitoneally (i.p.) in 3 doses (25, 50, and 100 mg/kg/day) for 21 days. Neurobehavioral tests were conducted within 24 h after the last day of injection. Afterwards, mice were sacrificed and their hippocampi were rapidly excised, weighed, and homogenized to be used for measuring biochemical parameters. Results. Treatment with Antia significantly improved mice performance in the Morris water maze. In addition, biochemical analysis showed that Antia exerted a protective effect for several compounds, including GSH, MDA, NF-κB, IL-6, TNF-α, and amyloid β. Further studies with western blot showed the protective effect of Antia for the JAK2/STAT3 pathway. Conclusions. Antia exerts a significant protection against cognitive dysfunction induced by ICV-STZ injection. This effect is achieved through targeting of the amyloidogenic, inflammatory, and oxidative stress pathways. The JAK2/STAT3 pathway plays a protective role for neuroinflammatory and neurodegenerative diseases such as SAD.

scholarly journals Aqueous extract of Pterocarpus santalinoides DC stem bark prevents L-NAME-induced hypertension in rat

2021 ◽  
Vol 10 (3) ◽  
pp. 166-172
Author(s):  
Chinte Yamjom Ramatou ◽  
◽  
Ngo Lemba Thom Esther ◽  
Florence Tsofack Ngueguim ◽  
Yannick Bekono Fouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Hdl Cholesterol ◽  
Experimental Period ◽  
Stem Bark ◽  
Renal Markers ◽  
Induced Hypertension ◽  
And Oxidative Stress ◽  
Pterocarpus Santalinoides

Background: Pterocarpus santalinoides stem bark is commonly used in Cameroonian medicine to treat many diseases including hypertension. Thus, this study was aimed to evaluate preventive effects of aqueous extract of Pterocarpus santalinoides (AEPS) stem bark on NG-Nitro-L-arginine-methyl ester (LNAME)-induced hypertension in rat. Methods: Normotensive rats received L-NAME (25 mg/kg intraperitoneally) concomitantly with AEPS (50, 100 and 200 mg/kg) or captopril (20 mg/kg) orally during 3 weeks. At the end of experimental period, arterial pressure and heart rate were recorded by invasive method. After sacrifice, blood, aorta and heart were harvested for biochemical analysis on homogenate. Results: Intraperitoneal injection of L-NAME induced in rat a significant increase (p < 0.001; p < 0.01; p < 0.05) of blood pressure, heart rate, malondialdehyde, total cholesterol, triglycerides, LDL-cholesterol, hepatic and renal markers functions. L-NAME also decreased significantly (p < 0.001; p < 0.01; p < 0.05) the levels of HDL-cholesterol, nitrites, glutathione, superoxide dismutase and catalase activities as compared to control rats. The AEPS prevented significantly the increase (p < 0.001) of hemodynamic parameters induced by L-NAME and various modifications of biochemical parameters (lipid profile, hepatic and renal markers functions) and oxidative stress markers evaluated. Conclusion: This study shows that the aqueous extract of Pterocarpus santalinoides prevents hypertension, dyslipidemia and oxidative stress induced by L-NAME in rat by attenuating endothelial dysfunction, liver and kidney’s damages

scholarly journals Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Hareram Birla ◽  
Chetan Keswani ◽  
Sachchida Nand Rai ◽  
Saumitra Sen Singh ◽  
Walia Zahra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Dysfunction ◽  
Withania Somnifera ◽  
Neuroprotective Effects ◽  
And Oxidative Stress

Mauritia flexuosa L. protects against deficits in memory acquisition and oxidative stress in rat hippocampus induced by methylmercury exposure

2016 ◽  
Vol 20 (5) ◽  
pp. 297-304 ◽  
Author(s):  
Luana K. R. Leão ◽  
Anderson M. Herculano ◽  
Caio Maximino ◽  
Alódia Brasil Costa ◽  
Amauri Gouveia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hippocampus ◽  
Mauritia Flexuosa ◽  
Methylmercury Exposure ◽  
Memory Acquisition ◽  
And Oxidative Stress

Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom

2011 ◽  
Vol 2 (6) ◽  
pp. 320 ◽  
Author(s):  
Vijayasree Vayalanellore Giridharan ◽  
Rajarajan Amirthalingam Thandavarayan ◽  
Tetsuya Konishi
Keyword(s):  
Oxidative Stress ◽  
Cognitive Dysfunction ◽  
Medicinal Mushroom ◽  
Inonotus Obliquus ◽  
And Oxidative Stress

Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats

2016 ◽  
Vol 31 (4) ◽  
pp. 779-791 ◽  
Author(s):  
Yeye Zhuo ◽  
Haibiao Guo ◽  
Yufang Cheng ◽  
Chuang Wang ◽  
Canmao Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Dysfunction ◽  
Phosphodiesterase 4 ◽  
And Oxidative Stress
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