Imbalance of RANK, RANKL and OPG expression during tibial fracture repair in diabetic rats

2008 ◽  
Vol 39 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Fernanda Penna Lima Guedes de Amorim ◽  
Sócrates Souza Ornelas ◽  
Sandoval Felicíssimo Diniz ◽  
Aline Carvalho Batista ◽  
Tarcília Aparecida da Silva
Keyword(s):  
Tibial Fracture ◽  
Diabetic Rats ◽  
Fracture Repair

scholarly journals Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats

2020 ◽  
Vol 8 (2) ◽  
pp. e001129
Author(s):  
Takahiro Oda ◽  
Takahiro Niikura ◽  
Tomoaki Fukui ◽  
Keisuke Oe ◽  
Yu Kuroiwa ◽  
...  
Keyword(s):  
Endochondral Ossification ◽  
Callus Formation ◽  
Femoral Shaft ◽  
Shaft Fracture ◽  
Diabetic Rats ◽  
Fracture Repair ◽  
Female Rats ◽  
Control Group ◽  
Type I ◽  
Biomechanical Assessment

IntroductionDiabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM.Research design and methodsA closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points.ResultsRadiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group.ConclusionsOur findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.

scholarly journals Bone plating for tibial fracture repair in a Black Buck Antelope cervicapra

2007 ◽  
Vol 22 (6) ◽  
pp. 2736-2736
Author(s):  
R.V. Suresh Kumar ◽  
S. Bharathi ◽  
G. Kamalakar ◽  
P. Veena ◽  
Thoiba Singh
Keyword(s):  
Tibial Fracture ◽  
Fracture Repair

scholarly journals The occurrence of osteosarcoma after tibial fracture repair in a dog

2021 ◽  
Vol 11 (1) ◽  
pp. 11-13
Author(s):  
Mitsuhiro Isaka ◽  
Daiki Kokubo ◽  
Toshikazu Sakai
Keyword(s):  
Tibial Fracture ◽  
Orthopedic Implants ◽  
Fracture Repair ◽  
Case Description ◽  
Surrounding Soft Tissue ◽  
Main Complaint ◽  
Metal Type ◽  
Veterinary Surgeons ◽  
Medical Materials ◽  
Amputation Surgery

Background: There are few detailed reports on implant-associated sarcoma in dogs; however, loose implants, metal type, and infection have not been shown as specific risk factors for this condition. Case Description: A 14-year-old spayed female Labrador retriever was referred to our hospital with a main complaint of chronic right hind lameness after previous tibial fracture repair. On radiographs, rupture of the bone plate and screws with swelling of the surrounding soft tissue was observed, and osteosarcoma (OSA) was diagnosed after histopathological examinations. During amputation surgery, a plastic band was found associated with the implant. Conclusion: Veterinary surgeons should be aware of implant-associated OSA and refrain from using non-medical materials in the implants. Furthermore, they should recommend the removal of orthopedic implants after fracture repair.

STIMULATION OF FRACTURE REPAIR BY PCM-4 IMMUNOMODULATION IN NORMAL AND DIABETIC RATS

1996 ◽  
Vol 89 (Supplement) ◽  
pp. S89
Author(s):  
Nona Colburn ◽  
Frank Sutton ◽  
Jack Lemmons
Keyword(s):  
Diabetic Rats ◽  
Fracture Repair ◽  
Stimulation Of

scholarly journals Surgical repair of a tibial fracture in a Belgian Landrace pig

2006 ◽  
Vol 19 (03) ◽  
pp. 180-183 ◽  
Author(s):  
A. Martens ◽  
J. Declercq ◽  
S. Schauvliege ◽  
L. Weiland ◽  
F. Gasthuys ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Animal Species ◽  
Tibial Fracture ◽  
Surgical Repair ◽  
Subcutaneous Fat ◽  
Fracture Repair ◽  
Cerclage Wire ◽  
Satisfactory Clinical Result ◽  
Landrace Pig ◽  
Steinmann Pin

SummaryThis paper reports the surgical treatment of a tibial fracture in a castrated adult male Belgian Landrace pig of 180 kg. The fracture was repaired using an intramedullary Steinmann pin, combined with cerclage wire and external transfixation. In contrast to other animal species, the fracture repair in the pig was hindered by the short and curved bones, the thick subcutaneous fat layer and the pronounced musculature. Postoperatively, the pig developed an osteomyelitis of the tibia due to pin tract contamination. Despite this complication, the fracture healed acceptably when all fixation material was removed two months after surgery. The infection resolved quickly and a satisfactory clinical result was obtained.

Percutaneous Electrical Stimulation for Clinical Tibial Fracture Repair

1976 ◽  
Vol 1976 (114) ◽  
pp. 290???295
Author(s):  
ROBERT L. ROMANO ◽  
ERNEST M. BURGESS ◽  
CHARLES P. RUBENSTEIN
Keyword(s):  
Electrical Stimulation ◽  
Tibial Fracture ◽  
Fracture Repair

scholarly journals The Repair of a Distal (one – third) Tibial Fracture in a Local Cock (Gallus gallus domesticus)

2018 ◽  
Vol 1 (1) ◽  
pp. 65-73
Author(s):  
R. O. S Okafor
Keyword(s):  
Tibial Fracture ◽  
Gallus Gallus ◽  
Fracture Repair ◽  
Gallus Domesticus ◽  
Radiographic Examination ◽  
Gallus Gallus Domesticus ◽  
Post Surgery ◽  
Intramedullary Pinning ◽  
Post Operation ◽  
The Right

A local cock(Gallus gallus domesticus) weighing 1.2 kg and kept as a pet was referred to the Veterinary Teaching Hospital (VTH), University of Abuja (UA) with the chief complaint of right limb lameness for three days. A close observation showed that the limb was dangling and had a fresh cut on the skin at the distal 1/3 of the tibia. The region was swollen and had a light-greenish colour suspected to be a sign of gangrene formation. Radiographic examination of the region confirmed a complete oblique simple fracture of the distal 1/3 of the tibia of the right limb. The cause of the fracture was unknown. Under Xylazine hydrochloride and Ketamine hydrochloride anaesthesia, the fracture was repaired through an open reduction with intramedullary pin. Eleven days post-surgery, the cock was found to bear slight weight on the limb. Clinical examination three weeks post operation showed normal usage of the limb and radiological evidence of good fracture healing. The intramedullary pinning appeared to be effective for the management of this simple tibial fracture in the local cock. This report appears to be the first intensive fracture repair documented in the local cock..

Success of a New Fiber Titanium Mesh in Adult Rabbit Tibial Fracture Repair and Reconstruction

2018 ◽  
Vol 8 (4) ◽  
pp. 515-520
Author(s):  
Juntao Song ◽  
Xianwei Wang ◽  
Takaki Shima ◽  
Yasuo Seki ◽  
Airong Li ◽  
...  
Keyword(s):  
Tibial Fracture ◽  
Fracture Repair ◽  
Adult Rabbit ◽  
Titanium Mesh
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