Labisia pumila prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model

2018 ◽  
Vol 26 (5) ◽  
pp. 1207-1217 ◽  
Author(s):  
Iffah Nadhira Madzuki ◽  
Seng Fong Lau ◽  
Nur Adeelah Che Ahmad Tantowi ◽  
Nur Iliyani Mohd Ishak ◽  
Suhaila Mohamed
Keyword(s):  
Rat Model ◽  
Joint Inflammation ◽  
Cartilage Degeneration ◽  
Osteoarthritis Cartilage ◽  
Labisia Pumila

scholarly journals Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression

2021 ◽  
Vol 22 (3) ◽  
pp. 1022
Author(s):  
Tatyana P. Makalish ◽  
Ilya O. Golovkin ◽  
Volodymyr V. Oberemok ◽  
Kateryna V. Laikova ◽  
Zenure Z. Temirova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Expression ◽  
Rat Model ◽  
Peripheral Blood ◽  
Antisense Oligonucleotide ◽  
Joint Inflammation ◽  
Blood Concentrations ◽  
Tnf Α ◽  
Effective Drugs ◽  
First Time

The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira®); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease.

The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis

2011 ◽  
Vol 133 (2) ◽  
pp. 538-542 ◽  
Author(s):  
Ahmad Nazrun Shuid ◽  
Leong Lee Ping ◽  
Norliza Muhammad ◽  
Norazlina Mohamed ◽  
Ima Nirwana Soelaiman
Keyword(s):  
Rat Model ◽  
Bone Markers ◽  
Post Menopausal Osteoporosis ◽  
Bone Calcium ◽  
Labisia Pumila ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

scholarly journals Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis

2016 ◽  
Vol 5 (5) ◽  
pp. 391-394 ◽  
Author(s):  
Nurdiana Nurdiana ◽  
Nelly Mariati ◽  
Noorhamdani Noorhamdani ◽  
Bambang Setiawan ◽  
Nicolaas Budhiparama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Post Menopausal Osteoporosis ◽  
Labisia Pumila ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

scholarly journals Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Jun Yamada ◽  
Kunikazu Tsuji ◽  
Kazumasa Miyatake ◽  
Yu Matsukura ◽  
Kahaer Abula ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Proinflammatory Cytokines ◽  
Synovial Membrane ◽  
Joint Inflammation ◽  
Cartilage Degeneration ◽  
Decoy Receptor ◽  
Arthritis Model ◽  
Cartilage Homeostasis ◽  
Articular Cartilage Degeneration ◽  
And Cartilage

Activins are proinflammatory cytokines which belong to the TGFβsuperfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model. Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin. Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin. In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage. These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis. Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration.

scholarly journals Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

2009 ◽  
Vol 60 (3) ◽  
pp. 840-847 ◽  
Author(s):  
Carl R. Flannery ◽  
Richard Zollner ◽  
Chris Corcoran ◽  
Aled R. Jones ◽  
Adam Root ◽  
...  
Keyword(s):  
Rat Model ◽  
Cartilage Degeneration
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