Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review

2017 ◽  
Vol 29 (6) ◽  
pp. 3109-3119 ◽  
Author(s):  
K. K. Asanka Sanjeewa ◽  
Won Woo Lee ◽  
Jae-Il Kim ◽  
You-Jin Jeon
Keyword(s):  
Biological Activities ◽  
Brown Seaweed ◽  
Industrial Applications ◽  
Ishige Okamurae

scholarly journals Pharmaceutical and Nutraceutical Potential Applications of Sargassum fulvellum

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Jian Liu ◽  
Sibusiso Luthuli ◽  
Qifang Wu ◽  
Mingjiang Wu ◽  
Jong-il Choi ◽  
...  
Keyword(s):  
Biological Activities ◽  
Wide Spectrum ◽  
Brown Seaweed ◽  
Industrial Applications ◽  
Anticancer Effects ◽  
Sargassum Fulvellum ◽  
Potential Applications ◽  
Potential Component ◽  
Anti Inflammatory ◽  
Urinary Problems

Sargassum fulvellum is a brown seaweed of the Sargassaceae family which has been demonstrated to exhibit antipyretic, analgesic, antiedema, antimicrobial, antioxidant, antitumor, neuroprotective, anticoagulative, anti-inflammatory, and hepatoprotective activities. It has been widely used as a food additive and as a medicine in oriental medicine to treat lumps, dropsy, swelling, testicular pains, and urinary problems. S. fulvellum has been identified as a potential producer of a wide spectrum of natural compounds such as carotenoids, fucoidans, and phlorotannins, showing different biological activities in various industrial applications including pharmaceutical, nutraceutical, cosmeceutical, and functional food. However, the promising health effects associated with the extracts and compounds isolated from S. fulvellum have not been reviewed to date. The present review thus focuses on the biological activity of S. fulvellum as reported by previous publications, which include antioxidant, anticoagulant, anti-inflammatory, neuroprotective, immunomodulatory, antidiabetic, and anticancer effects. Thus, this review might serve to increase the utilization of this invaluable natural source as a potential component in pharmaceutical and nutraceutical applications.

scholarly journals Isolation and Purification of Fucoxanthin from Brown Seaweed Sargassum horneri Using Open ODS Column Chromatography and Ethanol Precipitation

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3777
Author(s):  
Yuemei Ye ◽  
Jingwen Sun ◽  
Liting Wang ◽  
Junwang Zhu ◽  
Wei Cui ◽  
...  
Keyword(s):  
Column Chromatography ◽  
Recovery Rate ◽  
Biological Activities ◽  
Brown Seaweed ◽  
Sargassum Horneri ◽  
Scale Production ◽  
Water Mixture ◽  
Isolation And Purification ◽  
Ethanol Precipitation ◽  
Water Solvent

As an abundant marine xanthophyll, fucoxanthin (FX) exhibits a broad range of biological activities. The preparation of high-purity FX is in great demand, however, most of the available methods require organic solvents which cannot meet the green chemistry standard. In the present study, a simple and efficient purification approach for the purification of FX from the brown seaweed Sargassum horneri was carried out. The FX-rich ethanol extract was isolated by octadecylsilyl (ODS) column chromatography using ethanol–water solvent as a gradient eluent. The overwhelming majority of FX was successfully eluted by the ethanol–water mixture (9:1, v/v), with a recovery rate of 95.36%. A parametric study was performed to optimize the aqueous ethanol precipitation process by investigating the effects on the purity and recovery of FX. Under the optimal conditions, the purity of FX was 91.07%, and the recovery rate was 74.98%. Collectively, the eco-friendly method was cost-efficient for the purification of FX. The developed method provides a potential approach for the large-scale production of fucoxanthin from the brown seaweed Sargassum horneri.

scholarly journals Characterization of a New Intracellular Alginate Lyase with Metal Ions-Tolerant and pH-Stable Properties

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 416
Author(s):  
Yan Ma ◽  
Jie Li ◽  
Xin-Yue Zhang ◽  
Hao-Dong Ni ◽  
Feng-Biao Wang ◽  
...  
Keyword(s):  
Metal Ion ◽  
Brown Seaweed ◽  
Alginate Lyase ◽  
Industrial Applications ◽  
Alginate Oligosaccharides ◽  
Potential Applications ◽  
Pharmaceutical Industries ◽  
Ph Range ◽  
Alginate Lyases

Alginate lyases play an important role in alginate oligosaccharides (AOS) preparation and brown seaweed processing. Many extracellular alginate lyases have been characterized to develop efficient degradation tools needed for industrial applications. However, few studies focusing on intracellular alginate lyases have been conducted. In this work, a novel intracellular alkaline alginate lyase Alyw202 from Vibrio sp. W2 was cloned, expressed and characterized. Secretory expression was performed in a food-grade host, Yarrowia lipolytica. Recombinant Alyw202 with a molecular weight of approximately 38.3 kDa exhibited the highest activity at 45 °C and more than 60% of the activity in a broad pH range of 3.0 to 10.0. Furthermore, Alyw202 showed remarkable metal ion-tolerance, NaCl independence and the capacity of degrading alginate into oligosaccharides of DP2-DP4. Due to the unique pH-stable and high salt-tolerant properties, Alyw202 has potential applications in the food and pharmaceutical industries.

scholarly journals Macroalgae Derived Fungi Have High Abilities to Degrade Algal Polymers

2019 ◽  
Vol 8 (1) ◽  
pp. 52 ◽  
Author(s):  
Aleksandrina Patyshakuliyeva ◽  
Daniel L. Falkoski ◽  
Ad Wiebenga ◽  
Klaas Timmermans ◽  
Ronald P. de Vries
Keyword(s):  
Algal Biomass ◽  
Marine Fungi ◽  
Plant Biomass ◽  
Brown Seaweed ◽  
Industrial Applications ◽  
Good Growth ◽  
Biomass Degradation ◽  
Degrading Enzymes ◽  
Green Algal ◽  
Poor Understanding

Marine fungi associated with macroalgae are an ecologically important group that have a strong potential for industrial applications. In this study, twenty-two marine fungi isolated from the brown seaweed Fucus sp. were examined for their abilities to produce algal and plant biomass degrading enzymes. Growth of these isolates on brown and green algal biomass revealed a good growth, but no preference for any specific algae. Based on the analysis of enzymatic activities, macroalgae derived fungi were able to produce algae specific and (hemi-)cellulose degrading enzymes both on algal and plant biomass. However, the production of algae specific activities was lower than the production of cellulases and xylanases. These data revealed the presence of different enzymatic approaches for the degradation of algal biomass by macroalgae derived fungi. In addition, the results of the present study indicate our poor understanding of the enzymes involved in algal biomass degradation and the mechanisms of algal carbon source utilization by marine derived fungi.

Enzymatic synthesis of kojic acid esters and their potential industrial applications

2013 ◽  
Vol 67 (6) ◽  
Author(s):  
Ahmad Lajis ◽  
Mahiran Basri ◽  
Rosfarizan Mohamad ◽  
Muhajir Hamid ◽  
Siti Ashari ◽  
...  
Keyword(s):  
Kojic Acid ◽  
Biological Activities ◽  
Immobilized Lipase ◽  
Industrial Applications ◽  
Enzyme Loading ◽  
Initial Water ◽  
Advantages And Disadvantages ◽  
Anti Oxidant ◽  
Acyl Donors ◽  
Acid Esters

AbstractIn this paper, enzymatic methods for the synthesis of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (kojic acid) esters are reviewed. Important process parameters related to the synthesis of kojic acid esters such as the type of immobilized lipase, solvent, temperature, initial water activity, water content, pH, metal salts, enzyme loading, substrates mole ratio, and acyl donors are highlighted and discussed. The properties of kojic acid esters related to their solubility, stability, cytotoxicity, depigmenting activity, tyrosinase inhibitory, metal-chelating, anti-oxidant, and other biological activities are also highlighted. At present, kojic acid and its esters are widely used in cosmetic and skin health industries as skin whitening agents. The advantages and disadvantages of various kojic acid esters are compared and possible industrial applications of these derivatives are also discussed.

Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan

2014 ◽  
Vol 111 (03) ◽  
pp. 429-437 ◽  
Author(s):  
Cong Jiang ◽  
Sabine Knappe ◽  
Sabrina Reutterer ◽  
Christina Szabo ◽  
Michael Dockal ◽  
...  
Keyword(s):  
Charge Density ◽  
Biological Activities ◽  
Brown Seaweed ◽  
Structure Activity Relationship ◽  
Structural Features ◽  
Fucus Vesiculosus ◽  
Factor Ix ◽  
Activity Relationship ◽  
Structure Activity ◽  
The Impact

SummaryFucoidan is a highly complex sulfated polysaccharide commonly extracted from brown seaweed. In addition to their many biological activities, fucoidans have recently been demonstrated to inhibit or increase coagulation at different concentration ranges. Their structural features, i.e. molecular weight (Mw), Mw distribution, degree of sulfation, monosaccharide composition, and different linkages, are known to affect these activities. Therefore, structure-activity relationship (SAR) analysis of fucoidan is crucial for its potential use as a procoagulant. In this study, Fucus vesiculosus (F.v.) fucoidan was fractionated by charge and size as well as over- and desulfated to different degrees to yield preparations with various structural properties. The fractions’ pro- and anticoagulant activities were assessed by calibrated automated thrombography (CAT) and activated partial thromboplastin time (aPTT) assays. Binding to and inhibition of the anticoagulant protein tissue factor pathway inhibitor (TFPI) and the ability to activate coagulation via the contact pathway were also investigated. This paper discusses the impact of charge density, size, and sugar composition on fucoidan’s pro- and anticoagulant activities. Fucoidan requires a minimal charge density of 0.5 sulfates per sugar unit and a size of 70 sugar units to demonstrate desired procoagulant activities for improvement of haemostasis in factor VIII/factor IX-deficient plasma.

scholarly journals Review on Asymmetric Transformations with Chiral Phase-Transfer Catalysts

2019 ◽  
pp. 6-12
Author(s):  
Tesfaye Tebeka ◽  
Atitegebe Abera
Keyword(s):  
Unnatural Amino Acids ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Biological Activities ◽  
Industrial Applications ◽  
Cinchona Alkaloids ◽  
Chiral Phase ◽  
Asymmetric Transformations ◽  
Phase Transfer Catalysts ◽  
Chiral Phase Transfer Catalysts

This review focuses onasymmetric transformations with Chiral Phase-Transfer Catalysts and its application. Phase-transfer catalysis is practical methodology for organic synthesis. It is possible to achieve highly enantio selective transformations under phase-transfer conditions for a variety of ─C─C─ ─C─O─ and ─C─N─ bond-forming reactions. The asymmetric transformations using modified cinchona alkaloids, chiral spiro ammonium salts and crown ether are among the primary source of effective chiral phase-transfer catalyst, which allows access to enantiomerically pure unnatural amino acids and synthetically useful adducts containing quaternary stereogenic centers. The advantage of this method is its simple experimental procedure, large chiral pool, mild reaction condition, inexpensive, environmentally benign reagent and use of simple and inexpensive reactants. Nowadays, it appears to be the most important synthetic method used in various fields of organic chemistry, and also found widespread industrial applications. This review summarizes the synthesis application, enantio selective transformation of some selected reaction, biological activities and catalytic activities of Phase-transfer catalysis and especial emphasis is given for organo catalysis. In asymmetric organo catalyst, it is possible to obtain chiral organic products in high enantio enriched form by steric hindrance approach method. The advantage of organic molecules as chiral catalysts complements the traditional organo-metallic and biological approaches to asymmetric catalysis.

scholarly journals Cloning and Characterization of a New Chitosanase From a Deep-Sea Bacterium Serratia sp. QD07

2021 ◽  
Vol 12 ◽  
Author(s):  
Qiuling Zheng ◽  
Xiangjun Meng ◽  
Mingyang Cheng ◽  
Yanfeng Li ◽  
Yuanpeng Liu ◽  
...  
Keyword(s):  
Deep Sea ◽  
Biological Activities ◽  
Maximal Activity ◽  
Industrial Applications ◽  
Potential Candidate ◽  
Reaction Products ◽  
Industrial Manufacture ◽  
Encoding Gene ◽  
Ph Range

Chitosanase is a significant chitosan-degrading enzyme involved in industrial applications, which forms chitooligosaccharides (COS) as reaction products that are known to have various biological activities. In this study, the gene csnS was cloned from a deep-sea bacterium Serratia sp. QD07, as well as over-expressed in Escherichia coli, which is a new chitosanase encoding gene. The recombinant strain was cultured in a 5 L fermenter, which yielded 324 U/mL chitosanases. After purification, CsnS is a cold-adapted enzyme with the highest activity at 60°C, showing 37.5% of the maximal activity at 0°C and 42.6% of the maximal activity at 10°C. It exhibited optimum activity at pH 5.8 and was stable at a pH range of 3.4–8.8. Additionally, CsnS exhibited an endo-type cleavage pattern and hydrolyzed chitosan polymers to yield disaccharides and trisaccharides as the primary reaction products. These results make CsnS a potential candidate for the industrial manufacture of COS.

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