Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review

2017 ◽  
Vol 97 ◽  
pp. 228-237 ◽  
Author(s):  
Xirui He ◽  
Xiaoxiao Wang ◽  
Jiacheng Fang ◽  
Yu Chang ◽  
Ning Ning ◽  
...  
2013 ◽  
Vol 67 (6) ◽  
Author(s):  
Ahmad Lajis ◽  
Mahiran Basri ◽  
Rosfarizan Mohamad ◽  
Muhajir Hamid ◽  
Siti Ashari ◽  
...  

AbstractIn this paper, enzymatic methods for the synthesis of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (kojic acid) esters are reviewed. Important process parameters related to the synthesis of kojic acid esters such as the type of immobilized lipase, solvent, temperature, initial water activity, water content, pH, metal salts, enzyme loading, substrates mole ratio, and acyl donors are highlighted and discussed. The properties of kojic acid esters related to their solubility, stability, cytotoxicity, depigmenting activity, tyrosinase inhibitory, metal-chelating, anti-oxidant, and other biological activities are also highlighted. At present, kojic acid and its esters are widely used in cosmetic and skin health industries as skin whitening agents. The advantages and disadvantages of various kojic acid esters are compared and possible industrial applications of these derivatives are also discussed.


Author(s):  
Tesfaye Tebeka ◽  
Atitegebe Abera

This review focuses onasymmetric transformations with Chiral Phase-Transfer Catalysts and its application. Phase-transfer catalysis is practical methodology for organic synthesis. It is possible to achieve highly enantio selective transformations under phase-transfer conditions for a variety of ─C─C─ ─C─O─ and ─C─N─ bond-forming reactions. The asymmetric transformations using modified cinchona alkaloids, chiral spiro ammonium salts and crown ether are among the primary source of effective chiral phase-transfer catalyst, which allows access to enantiomerically pure unnatural amino acids and synthetically useful adducts containing quaternary stereogenic centers. The advantage of this method is its simple experimental procedure, large chiral pool, mild reaction condition, inexpensive, environmentally benign reagent and use of simple and inexpensive reactants. Nowadays, it appears to be the most important synthetic method used in various fields of organic chemistry, and also found widespread industrial applications. This review summarizes the synthesis application, enantio selective transformation of some selected reaction, biological activities and catalytic activities of Phase-transfer catalysis and especial emphasis is given for organo catalysis. In asymmetric organo catalyst, it is possible to obtain chiral organic products in high enantio enriched form by steric hindrance approach method. The advantage of organic molecules as chiral catalysts complements the traditional organo-metallic and biological approaches to asymmetric catalysis.


2021 ◽  
Vol 12 ◽  
Author(s):  
Qiuling Zheng ◽  
Xiangjun Meng ◽  
Mingyang Cheng ◽  
Yanfeng Li ◽  
Yuanpeng Liu ◽  
...  

Chitosanase is a significant chitosan-degrading enzyme involved in industrial applications, which forms chitooligosaccharides (COS) as reaction products that are known to have various biological activities. In this study, the gene csnS was cloned from a deep-sea bacterium Serratia sp. QD07, as well as over-expressed in Escherichia coli, which is a new chitosanase encoding gene. The recombinant strain was cultured in a 5 L fermenter, which yielded 324 U/mL chitosanases. After purification, CsnS is a cold-adapted enzyme with the highest activity at 60°C, showing 37.5% of the maximal activity at 0°C and 42.6% of the maximal activity at 10°C. It exhibited optimum activity at pH 5.8 and was stable at a pH range of 3.4–8.8. Additionally, CsnS exhibited an endo-type cleavage pattern and hydrolyzed chitosan polymers to yield disaccharides and trisaccharides as the primary reaction products. These results make CsnS a potential candidate for the industrial manufacture of COS.


Tetrahedron ◽  
2021 ◽  
pp. 132001
Author(s):  
Suélen Karine Sartori ◽  
Marisa Alves Nogueira Diaz ◽  
Gaspar Diaz-Muñoz

2020 ◽  
Vol 11 (4) ◽  
pp. 11077-11087

Ferula gummosa (Apiaceae) Boiss. as a valuable herbal medicine possesses various medical and industrial applications. The oleo-gum resin of F. gummosa, called Galbanum, holds several biological activities for its numerous terpenoid compounds. This study has been conducted on quality control of the F. gummosa oleo-gum resin prepared from standard plants, and commercial samples belong to different parts of Iran. For this purpose, essential oil and dichloromethane extracts and standard fruit essential oil were obtained and evaluated by Gas Chromatography/Mass Spectrometry (GC/MS). Moreover, all dichloromethane oleo-gum resin samples (Standards and commercials) were qualitatively analyzed by High-Performance Thin-Layer Chromatography (HPTLC). Based on the GC/MS analysis, β-Pinene, δ-3-Carene and, α-Pinene in standard and β-Pinene, α-Pinene and, δ-3-Carene in essential oil, commercial samples were recognized as major compounds, respectively. The GC/MS analysis indicates that all commercial oleo-gum resin samples may obtain from the rhizome except one of them. The HPTLC analysis also revealed that the same spot pattern in all samples might be related to the major resin constituents. However, the source of oleo-gum resin could not be clarifying. Based on the results, both GC/FID and HPTLC analysis are useful methods for quality control of oleo-gum resin. The plant part used for oleo-resin extraction can be recognized via the percentage of essential compounds in it.


Author(s):  
V.V. Bhuva ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – methoxy - 4" - [2 - ( 4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitrile( 4a-4l ) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50µg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.


Author(s):  
Hatim A. El-Baz ◽  
Ahmed M. Elazzazy ◽  
Tamer S. Saleh ◽  
Panagiotis Dritsas ◽  
Jazem A. Mahyoub ◽  
...  

AbstractFatty acid amides (FAAs) are of great interest due to their broad industrial applications. They can be synthesized enzymatically with many advantages over chemical synthesis. In this study, the fatty acid moieties of lipids of Cunninghamella echinulata ATHUM 4411, Umbelopsis isabellina ATHUM 2935, Nannochloropsis gaditana CCAP 849/5, Olive oil and an eicosapentaenoic acid (EPA) concentrate were converted into their fatty acid methyl esters and used in the FAA (i.e. ethylene diamine amides) enzymatic synthesis, using lipases as biocatalysts. The FAA synthesis, monitored using in situ NMR, FT-IR and thin-layer chromatography, was catalyzed efficiently by the immobilized Candida rugosa lipase. The synthesized FAAs exhibited a significant antimicrobial activity, especially those containing oleic acid in high proportions (i.e. derived from Olive oil and U. isabellina oil), against several human pathogenic microorganisms, insecticidal activity against yellow fever mosquito, especially those of C. echinulata containing gamma linolenic acid, and anti-cancer properties against SKOV-3 ovarian cancer cell line, especially those containing EPA in their structures (i.e. EPA concentrate and N. gaditana oil). We conclude that FAAs can be efficiently synthesized using microbial oils of different fatty acid composition and used in specific biological applications.


2021 ◽  
Vol 5 ◽  
Author(s):  
Fernanda Cortez Lopes ◽  
Rodrigo Ligabue-Braun

Many commodities are abundantly produced around the world, including soybean, corn, rice sugarcane, cassava, coffee, fruits, and many others. These productions are responsible for the generation of enormous amounts of daily residues, such as cassava and sugarcane bagasses, rice husk, and coffee peel. These residues are rich sources for renewable energy and can be used as substrates for industrial interest products. Microorganisms are useful biofactories, capable of producing important primary and secondary metabolites, including alcohol, enzymes, antibiotics, pigments, and many other molecules. The production of pigments was reported in bacteria, filamentous fungi, yeasts, and algae. These natural microbial pigments are very promising because synthetic colorants present a long history of allergies and toxicity. In addition, many natural pigments present other biological activities, such as antioxidant and antimicrobial activities, that are interesting for industrial applications. The use of inexpensive substrates for the production of these metabolites is very attractive, considering that agro-industrial residues are generated in high amounts and usually are a problem to the industry. Therefore, in this article we review the production of microbial pigments using agro-industrial residues during the current decade (2010–2020), considering both submerged and solid state fermentations, wild-type and genetically modified microorganisms, laboratorial to large-scale bioprocesses, and other possible biological activities related to these pigments.


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