The preliminary performance study of the 3D printing of a tricalcium phosphate scaffold for the loading of sustained release anti-tuberculosis drugs

2014 ◽  
Vol 50 (5) ◽  
pp. 2138-2147 ◽  
Author(s):  
Jing Yuan ◽  
Ping Zhen ◽  
Hongbin Zhao ◽  
Keming Chen ◽  
Xusheng Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Sustained Release ◽  
Tricalcium Phosphate ◽  
Performance Study

scholarly journals Performance Study of Grass-Derived Nano-Cellulose and Polycaprolactone Composites for 3D Printing

2021 ◽  
Vol 11 (3) ◽  
pp. 1273
Author(s):  
Chen Feng ◽  
Jiping Zhou ◽  
Xiaodong Xu ◽  
Yani Jiang ◽  
Hongcan Shi ◽  
...  
Keyword(s):  
3D Printing ◽  
Mechanical Test ◽  
Chemical Properties ◽  
Test Results ◽  
Performance Study ◽  
Compression Process ◽  
Ansys Fluent ◽  
Nano Cellulose ◽  
Physical And Chemical ◽  
And Chemical Properties

In recent years, 3D printing has received increasing attention from researchers. This technology overcomes the limitations of traditional technologies by printing precise and personalized scaffold with arbitrary shapes, pore structures, and porosities for the applications in various tissues. The cellulose nanocrystal (CNC) is extracted from Humulus Japonicus (HJS) and mixed with poly(ε-caprolactone) (PCL) to prepare a series of CNC/PCL composites for printing. Based on the analysis of the physical and chemical properties of the series of the CNC/PCL composites, an optimal mass ratio of CNC to PCL was obtained. The Solidworks was used to simulate the stretching and compression process of the scaffolds with three different patterns under an external force. The flow of nutrient solution in the scaffolds with different patterns was simulated by ANSYS FLUENT, and then a new optimization scaffold pattern with a concave hexagon shape was advised based on the simulation results. Collectively, the mechanical test results of the material and scaffold confirmed that the optimal filling amount of the CNC was 5%, and the scaffold pattern with concave hexagon shape exhibited better mechanical properties and suitable for the transport of cells and nutrients, which is expected to be more widely used in 3D printing.

3D printed polycaprolactone/beta-tricalcium phosphate/magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing the large bone defect

2021 ◽  
Author(s):  
Ziyue Peng ◽  
Chengqiang Wang ◽  
Chun Liu ◽  
Haixia Xu ◽  
Yihan Wang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Large Bone Defect ◽  
Beta Tricalcium Phosphate ◽  
Defect Area ◽  
3D Printed ◽  
Magnesium Peroxide ◽  
Large Bone ◽  
Phosphate Magnesium

Fabricate a MgO2-contained scaffold by 3D printing to improve ischemia and hypoxia in bone defect area.

Highly Filled Compositions Based on Alginate Gel and Fine Tricalcium Phosphate for 3D Printing of Tissue-Engineered Matrices

2020 ◽  
Vol 11 (5) ◽  
pp. 1137-1143
Author(s):  
A. V. Mironov ◽  
O. A. Mironova ◽  
A. O. Mariyanats ◽  
V. S. Komlev ◽  
I. V. Smirnov ◽  
...  
Keyword(s):  
3D Printing ◽  
Tricalcium Phosphate ◽  
Alginate Gel

scholarly journals Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

Polymers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 27 ◽  
Author(s):  
Deck Khong Tan ◽  
Mohammed Maniruzzaman ◽  
Ali Nokhodchi
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Sustained Release ◽  
Hot Melt Extrusion ◽  
Pharmaceutical Products ◽  
Successful Implementation ◽  
Melt Extrusion ◽  
Fused Deposition ◽  
Continuous Fabrication ◽  
Hot Melt

This study reports a thorough investigation combining hot-melt extrusion technology (HME) and a low-cost fused deposition modelling (FDM) 3D printer as a continuous fabrication process for a sustained release drug delivery system. The successful implementation of such an approach presented herein allows local hospitals to manufacture their own medical and pharmaceutical products on-site according to their patients’ needs. This will help save time from waiting for suitable products to be manufactured off-site or using traditional manufacturing processes. The filaments were produced by optimising various compositions of pharmaceutical-grade polymers, such as hydroxypropyl cellulose (HPC), Eudragit® (RL PO), and polyethylene glycol (PEG), whereas theophylline was used as a model thermally stable drug. For the purpose of the study, twin-screw hot-melt extrusion (HME) was implemented from the view that it would result in the formation of solid dispersion of drug in the polymeric carrier matrices by means of high shear mixing inside the heated barrel. Four filament compositions consisting of different ratios of polymers were produced and their properties were assessed. The mechanical characterisation of the filaments revealed quite robust properties of the filaments suitable for FDM 3D printing of caplets (PrintCap), whereas the solid-state analyses conducted via DSC and XRD showed amorphous nature of the crystalline drug dispersed in the polymeric matrices. Moreover, the surface analysis conducted via SEM showed a smooth surface of the produced filaments as well as caplets where no drug crystals were visible. The in vitro drug release study showed a sustained release profile over 10 h where about 80% of the drug was released from the printed dosage forms. This indicates that our optimised 3D printed caplets could be suitable for the development of sustained release on-demand drug delivery systems.

scholarly journals Controlled Release of Bi-Layered Delphinidin Tablets Using 3D Printing Techniques

2020 ◽  
pp. 73-81
Author(s):  
Tejinder Kaur ◽  
Satish Kumar Sharma
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Sustained Release ◽  
Immediate Release ◽  
Drug Formulation ◽  
3D Printer ◽  
Anti Cancer ◽  
Pharmaceutical Industries ◽  
Medicinal Properties ◽  
Printing Techniques

Delphinidin is a known dye and food colorant along with many medicinal properties for instance anti-inflammatory, anti-microbial, anti-diabetic, anti-obesity and anti-cancer. The present research has been designed to formulate bi-layered tablets using delphinidin which inherits these medicinal properties. The extrusion of tablets is done by using 3D printing techniques involving a table-top 3D printer which extrudes delphinidin tablets along with the required excipients. The characteristics of the whole tablets have been analyzed separately including hardness, friability, and weight. Adapted method for tablet formulation results in tablets which are appropriate for the immediate release and sustained release. The present research provides a method to make the effective tablets with reduced cost which can be used as drug formulation method in pharmaceutical industries.

Dicarboxylate-substituted octacalcium phosphates for hydrogel filling and resorbable ceramics fabrication

2020 ◽  
Vol 12 ◽  
pp. 27-41
Author(s):  
A. A. Tikhonov ◽  
◽  
E. S. Klimashina ◽  
P. V. Evdokimov ◽  
E. V. Kukueva ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
3D Printing ◽  
Tricalcium Phosphate ◽  
Decomposition Product ◽  
Octacalcium Phosphate ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Buffer Solutions ◽  
Hydrolysis Of ◽  
Printing Method

The main features of the synthesis of carboxylate-substituted analogs of octacalcium phosphate Ca8(HPO4)2(PO4)4·5H2O (OCP) by hydrolysis of brushite (CaHPO4·2H2O) and tricalcium phosphate α-Са3(РО4)2 (α-TCP) in buffer solutions based on the salts of succinic, adipic, and citric acids were summarized. The synthesis of succinate-substituted (Suc@OCP) and adipinate-substituted (Adi@OCP) OCPs gives the powders with Ca8(HPO4)2 – xАx(PO4)4·zH2O (А = Suc, Аdi) composition. Thermolysis of substituted OCPs results in a mixture of β-Са3(РО4)2 (β-TCP) and hydroxyapatite Са10(РО4)6(ОН)2 (HAp). Thermolysis features include the absence of an apatite-like decomposition product of pure OCP and higher decomposition temperatures compared to the pure OCP. Suc@OCP and Adi@OCP powders were used for the filling of hydrogels based on polyethylene glycol diacrylate (PEGDA) for the creation of a deformable composite implant by a stereolithographic 3D printing method, and fabrication of biphasic TCP/HAp ceramics.

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