scholarly journals Thromboinflammation as bioactivity assessment of H2O2-alkali modified titanium surfaces

2019 ◽  
Vol 30 (6) ◽  
Author(s):  
Gry Hulsart-Billström ◽  
Oscar Janson ◽  
Håkan Engqvist ◽  
Ken Welch ◽  
Jaan Hong
Keyword(s):  
Platelet Aggregation ◽  
Complement Activation ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Coagulation Activation ◽  
Commercially Pure ◽  
A Cell ◽  
Modified Surface ◽  
Titanium Surfaces ◽  
Titanium Grade

Abstract The release of growth factors from platelets, mediated by the coagulation and the complement system, plays an important role in the bone formation around implants. This study aimed at exploring the thromboinflammatory response of H2O2-alkali soaked commercially pure titanium grade 2 discs exposed to whole human blood, as a way to assess the bioactivity of the discs. Commercially pure titanium grade 2 discs were modified by soaking in H2O2, NaOH and Ca(OH)2. The platelet aggregation, coagulation activation and complement activation was assessed by exposing the discs to fresh whole blood from human donors. The platelet aggregation was examined by a cell counter and the coagulation and complement activation were assessed by ELISA-measurements of the concentration of thrombin-antithrombin complex, C3a and terminal complement complex. The modified surface showed a statistically significant increased platelet aggregation, coagulation activation and complement activation compared to unexposed blood. The surface also showed a statistically significant increase of coagulation activation compared to PVC. The results of this study showed that the H2O2-alkali soaked surfaces induced a thromboinflammatory response that indicates that the surfaces are bioactive.

UPM CP TITANIUM GRADE 3 (UNS R50550)

Alloy Digest ◽  
2020 ◽  
Vol 69 (6) ◽  
Keyword(s):  
Corrosion Resistance ◽  
Pure Titanium ◽  
Heat Treating ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Continuous Service ◽  
Pure Grade ◽  
Grade 3 ◽  
Titanium Grade ◽  
Design Stress

Abstract UPM CP Titanium Grade 3 (UNS R50550) is an unalloyed commercially pure titanium that exhibits moderate strength (higher strength than that of Titanium Grade 2), along with excellent formability and corrosion resistance. It offers the highest ASME allowable design stress of any commercially pure grade of titanium, and can be used in continuous service up to 425 °C (800 °F) and in intermittent service up to 540 °C (1000 °F). This datasheet provides information on composition, physical properties, and elasticity. It also includes information on corrosion resistance as well as forming, heat treating, machining, and joining. Filing Code: Ti-167. Producer or source: United Performance Metals.

Wettability and osteoblastic cell adhesion on ultrapolished commercially pure titanium surfaces: the role of the oxidation and pollution states

2014 ◽  
Vol 28 (12) ◽  
pp. 1207-1218 ◽  
Author(s):  
Miguel A. Fernández-Rodríguez ◽  
Alda Y. Sánchez-Treviño ◽  
Elvira De Luna-Bertos ◽  
Javier Ramos-Torrecillas ◽  
Olga García-Martínez ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Pure Titanium ◽  
Osteoblastic Cell ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Titanium Surfaces

scholarly journals The Effects Of Friction On Stamping Process Of Sheet Metals Used In Aviation

2015 ◽  
Vol 60 (3) ◽  
pp. 1895-1900 ◽  
Author(s):  
K. Dyja ◽  
W. Więckowski
Keyword(s):  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Spherical Cap ◽  
Drawing Test ◽  
Commercially Pure ◽  
Stamping Process ◽  
Strip Drawing ◽  
Titanium Grade ◽  
The Impact ◽  
Lubrication Conditions

Abstract An important factor in the possibility of obtaining correct drawn parts with the desired functional properties is the friction between the stamped sheet and the tool. The article discusses the impact of technological lubricants developed according to our own formulas, based on vegetable oils, on the stamping process taking into account the strain distributions in the drawn parts. Biodegradable lubricants based on rapeseed oil with an addition of stearic acid or boric acid were used. The results of the friction coefficient in a strip drawing test and the numerical analysis results of the stamping process of a spherical cap from sheet metal: aluminium 2024, commercially pure titanium Grade 2, steel 5604 in dry friction and lubrication conditions, are presented. Strain distributions and changes in the drawn part wall thickness were analysed.

scholarly journals Platelet Adhesion on Commercially Pure Titanium Plates in Vitro II. Immunofluorescence Visualization of PDGF-B, TGFβ1, and PPARγ Released from Activated Adherent Platelets

2019 ◽  
Vol 7 (4) ◽  
pp. 109 ◽  
Author(s):  
Tetsuhiro Tsujino ◽  
Akira Takahashi ◽  
Taisuke Watanabe ◽  
Kazushige Isobe ◽  
Yutaka Kitamura ◽  
...  
Keyword(s):  
Industrial Development ◽  
Platelet Adhesion ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Titanium Surfaces ◽  
Cp Ti

Recent progress in the industrial development of dental implants has improved their surface bio-affinity, while clinical implantologists attempt to improve it through coating with various compounds, including platelet-rich plasma (PRP) in clinical settings. However, it is poorly understood how PRP acts on titanium surfaces. To validate this surface modification method and demonstrate how platelet-derived soluble biomolecules released from the activated adherent platelets act on plain, commercially pure-titanium (cp-Ti) plates, we evaluated the distribution of biomolecules by immunofluorescence. PPARγ, PDGF-B, and TGFβ1 were similarly released at immunofluorescence levels from activated adherent platelets, retained in the surrounding extra-platelet spaces for a while, and did not immediately diffuse away to distant spaces. Exogenously added CaCl2 augmented release and retention of those biomolecules along with activation and aggregation. Taken together with our previous data regarding platelet adhesion, these findings suggest that especially when treated with CaCl2, platelets immediately adhere on cp-Ti plates to release their stored biomolecules in the absence of plasma proteins and that these biomolecules do not diffuse away, but stay longer in extra-platelet spaces around the platelets by newly formed, immature fibrin fiber fragments. Consequently, these retained biomolecules are anticipated to cooperatively stabilize implants by stimulating alveolar bone regeneration and integration.

Possibilities of biocompatible material production using conform SPD technology

2017 ◽  
Vol 1 (88) ◽  
pp. 5-11 ◽  
Author(s):  
J. Palán ◽  
L. Maleček ◽  
J. Hodek ◽  
M. Zemko ◽  
J. Dzugan
Keyword(s):  
Mechanical Properties ◽  
Dental Implants ◽  
Nanostructured Materials ◽  
Continuous Production ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Ultrafine Grained ◽  
Materials Research ◽  
Titanium Grade

Purpose: At present, materials research in the area of SPD (severe plastic deformation) processes is very intensive. Materials processed by these techniques show better mechanical properties and have finer grain when compared to the input feedstock. The refined microstructure may be ultrafine-grained or nanostructured, where the grain size becomes less than 100 nm. One of the materials used for such processes is CP (commercially pure) titanium of various grades, which is widely used for manufacturing dental implants. The article deals with one of the technologies available for the production of ultrafine-grained titanium: Conform technology. CP titanium processed by CONFORM technology exhibits improved mechanical properties and very favourable biocompatibility, due to its fine-grained structure. The article presents the current experience in the production of ultrafine CP titanium using this technology. The main objective of this article is describing the behaviour of CP titanium during forming in the Conform device and its subsequent use in dental implantology. Design/methodology/approach: In the present study, commercially pure Grade 2 titanium was processed using the CONFORM machine. The numerical simulation of the process was done using FEM method with DEFORMTM software. The evaluation was performed by simple tensile testing and transmission electron microscopy. The first conclusions were derived from the determined mechanical properties and based on analogies in available publications on a similar topic. Findings: This study confirmed that the SPD process improves mechanical properties and does not impair the ductility of the material. The CONFORM process enables the continuous production of ultrafine-grained or nanostructured materials. Research limitations/implications: At the present work, the results show the possible way of continuous production of ultrafine-grained or nanostructured materials. Nevertheless, the further optimization is needed in order to improve the final quality of wires and stabilize the process. As these factors will be solved, the technology will be ready for the industry. Practical implications: The article gives the practical information about the continuous production of ultrafine-grained pure titanium Grade 2 and the possibility of use this material for dental implants. Originality/value: The present paper gives information about the influence of the CONFORM technology on final mechanical and structural properties with the emphasis on technological aspects

scholarly journals Biomimetic coatings enhance tribocorrosion behavior and cell responses of commercially pure titanium surfaces

2016 ◽  
Vol 11 (3) ◽  
pp. 031008 ◽  
Author(s):  
Isabella da Silva Vieira Marques ◽  
Maria Fernanda Alfaro ◽  
Miki Taketomi Saito ◽  
Nilson Cristino da Cruz ◽  
Christos Takoudis ◽  
...  
Keyword(s):  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Cell Responses ◽  
Commercially Pure ◽  
Titanium Surfaces

scholarly journals Impact of rolling conditions on the hydriding of grade 2 titanium welded tubes

2020 ◽  
Vol 321 ◽  
pp. 09005
Author(s):  
La Chance LEPEMANGOYE ◽  
Nicolas CRETON ◽  
Virgil OPTASANU ◽  
Elise DELOYE ◽  
Tony MONTESIN ◽  
...  
Keyword(s):  
Cold Rolling ◽  
Crystallographic Texture ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Asymmetrical Rolling ◽  
Commercially Pure ◽  
Pole Figures ◽  
Cold Rolled ◽  
Titanium Grade ◽  
The Impact

In this article, we study the impact of rolling conditions on the texture of the commercially pure titanium grade 2. In a previous work, NEOTISS in collaboration with ICB laboratory, shown that the texture highly influences the precipitation of hydrides in Titanium. In order to create different textures, Titanium sheets grade 2 are cold rolled asymmetrically and symmetrically with or without lubricant. The inverse pole figures and direct pole figures obtained allow us to deduce that symmetrical cold rolling does not change the grains orientation but generates a rotation of grains along c-axis (normal to basal plan). However, asymmetrical cold rolling leads to the formation of a new crystallographic texture, which could limit the formation of the hydrides in titanium grade 2 submitted to a hydrogen-rich environment. Key words: asymmetrical rolling, symmetrical rolling, titanium, hydriding, texture

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