The cytotoxic and apoptotic effects of beta-blockers with different selectivity on cancerous and healthy lung cell lines

Author(s):  
Berna Kavakcıoğlu Yardımcı ◽  
Fatime Geyikoglu ◽  
Ferhunde Aysin ◽  
Kubra Koc ◽  
Nihal Simsek Ozek ◽  
...  
Author(s):  
Paola Castillo-Juárez ◽  
Sebastián C. Sanchez ◽  
Alma D. Chávez-Blanco ◽  
Humberto Mendoza-Figueroa ◽  
José Correa-Basurto

Background and Objective: Histone deacetylases (HDACs) are important therapeutic targets for many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), has antiproliferative properties on some cancer cell lines and inhibits the HDAC1 isoform. Materials and Methods: In this work, HO-AAVPA was tested as an antiproliferative agent in U87-MG (human glioblastoma) and U-2 OS cells (human osteosarcoma), which are types of cancer that are difficult to treat, and its antiangiogenic properties were explored. Results: HO-AAVPA had antiproliferative effects at 48 h with an IC50 = 0.655 mM in U87-MG cells and an IC50 = 0.453 mM in U-2 OS cells. Additionally, in the colony formation assay, HO-AAVPA decreased the number of colonies by approximately 99% in both cell lines and induced apoptosis by 31.3% in the U-2 OS cell line and by 78.2% in the U87-MG cell line. Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA. Conclusion: HO-AAVPA has antiproliferative effects on glioblastoma and osteosarcoma and antiangiogenic properties.


Biologia ◽  
2021 ◽  
Author(s):  
Neslihan Tekin Karacaer ◽  
Barış Kerimoğlu ◽  
Talat Baran ◽  
Mehtap Tarhan ◽  
Ayfer Menteş ◽  
...  

2013 ◽  
Vol 23 (1) ◽  
pp. 158-162 ◽  
Author(s):  
Nguyen Huu Tung ◽  
Takuhiro Uto ◽  
Ayana Sakamoto ◽  
Yuka Hayashida ◽  
Yuuki Hidaka ◽  
...  

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