Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study

2005 ◽  
Vol 72 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Maode Wang ◽  
Daizo Yoshida ◽  
Shouxun Liu ◽  
Akira Teramoto
Keyword(s):  
Cell Lines ◽  
Cell Invasion ◽  
Glioma Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Glioma Cell Lines

scholarly journals An in vitro study, evaluating the effect of sunitinib and/or lapatinib on two glioma cell lines

2009 ◽  
Vol 28 (5) ◽  
pp. 554-560 ◽  
Author(s):  
Efstathia Giannopoulou ◽  
Konstantinos Dimitropoulos ◽  
Andreas A. Argyriou ◽  
Angelos K. Koutras ◽  
Fotinos Dimitrakopoulos ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Glioma Cell Lines

Comparative In Vitro Study of 11C-Methionine and 11C-Deuterodeprenyl Uptake in Three Human Glioma Cell Lines

2017 ◽  
Vol 32 (9) ◽  
pp. 344-350
Author(s):  
Elena Vasilskis ◽  
Ingrid Kreimerman ◽  
Silvia Olivera ◽  
Eduardo Savio ◽  
Henry Engler
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines

Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: An in vitro study

2008 ◽  
Vol 586 (1-3) ◽  
pp. 24-34 ◽  
Author(s):  
Andressa Bernardi ◽  
Rudimar L. Frozza ◽  
Eliézer Jäger ◽  
Fabrício Figueiró ◽  
Luci Bavaresco ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Cell Lines ◽  
Glioma Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Selective Cytotoxicity ◽  
Glioma Cell Lines

Effect of black seeds (Nigella sativa) volatile oil on the cervical cancer: In vitro study, on Hela cell lines

2019 ◽  
Vol 7 (4) ◽  
pp. 91-96
Author(s):  
Isra'a Al-sobhi ◽  
◽  
Rawan Al-Ghabban ◽  
Soad Shaker Ali ◽  
Jehan Al-Amri ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hela Cell ◽  
Cell Lines ◽  
Nigella Sativa ◽  
In Vitro Study ◽  
Volatile Oil ◽  
Vitro Study ◽  
Hela Cell Lines ◽  
Black Seeds

scholarly journals Temozolomide sensitivity of malignant glioma cell lines – a systematic review assessing consistencies between in vitro studies

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Michael T. C. Poon ◽  
Morgan Bruce ◽  
Joanne E. Simpson ◽  
Cathal J. Hannan ◽  
Paul M. Brennan
Keyword(s):  
Cell Viability ◽  
Malignant Glioma ◽  
Cell Line ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
In Vitro Studies ◽  
Experimental Conditions ◽  
Glioma Cell Lines

Abstract Background Malignant glioma cell line models are integral to pre-clinical testing of novel potential therapies. Accurate prediction of likely efficacy in the clinic requires that these models are reliable and consistent. We assessed this by examining the reporting of experimental conditions and sensitivity to temozolomide in glioma cells lines. Methods We searched Medline and Embase (Jan 1994-Jan 2021) for studies evaluating the effect of temozolomide monotherapy on cell viability of at least one malignant glioma cell line. Key data items included type of cell lines, temozolomide exposure duration in hours (hr), and cell viability measure (IC50). Results We included 212 studies from 2789 non-duplicate records that reported 248 distinct cell lines. The commonest cell line was U87 (60.4%). Only 10.4% studies used a patient-derived cell line. The proportion of studies not reporting each experimental condition ranged from 8.0–27.4%, including base medium (8.0%), serum supplementation (9.9%) and number of replicates (27.4%). In studies reporting IC50, the median value for U87 at 24 h, 48 h and 72 h was 123.9 μM (IQR 75.3–277.7 μM), 223.1 μM (IQR 92.0–590.1 μM) and 230.0 μM (IQR 34.1–650.0 μM), respectively. The median IC50 at 72 h for patient-derived cell lines was 220 μM (IQR 81.1–800.0 μM). Conclusion Temozolomide sensitivity reported in comparable studies was not consistent between or within malignant glioma cell lines. Drug discovery science performed on these models cannot reliably inform clinical translation. A consensus model of reporting can maximise reproducibility and consistency among in vitro studies.

scholarly journals Investigating the impact of alpha/beta and LET d on relative biological effectiveness in scanned proton beams: An in vitro study based on human cell lines

2020 ◽  
Vol 47 (8) ◽  
pp. 3691-3702 ◽  
Author(s):  
Elisabeth Mara ◽  
Monika Clausen ◽  
Suphalak Khachonkham ◽  
Simon Deycmar ◽  
Clara Pessy ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Relative Biological Effectiveness ◽  
In Vitro Study ◽  
Vitro Study ◽  
Human Cell Lines ◽  
Biological Effectiveness ◽  
Alpha Beta ◽  
The Impact

Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines

2020 ◽  
Vol 38 (1) ◽  
pp. 36-46
Author(s):  
Jnanranjan Panda ◽  
Bhabani Sankar Satapathy ◽  
Bidisha Mandal ◽  
Ramkrishna Sen ◽  
Biswajit Mukherjee ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cobalt Ferrite ◽  
In Vitro Study ◽  
Vitro Study ◽  
Mcf 7

scholarly journals Aminolevulinic Acid-Mediated Photodynamic Therapy of Human Meningioma: An in Vitro Study on Primary Cell Lines

2015 ◽  
Vol 16 (12) ◽  
pp. 9936-9948 ◽  
Author(s):  
Mustafa El-Khatib ◽  
Carolin Tepe ◽  
Brigitte Senger ◽  
Maxine Dibué-Adjei ◽  
Markus Riemenschneider ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Lines ◽  
Aminolevulinic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Primary Cell ◽  
Human Meningioma ◽  
Primary Cell Lines

scholarly journals MicroRNA-374a Governs Aggressive Cell Behaviors of Glioma by Targeting Prokineticin 2

2019 ◽  
Vol 18 ◽  
pp. 153303381882140 ◽  
Author(s):  
Ye Zhang ◽  
Rui Zhang ◽  
Rui Sui ◽  
Yi Chen ◽  
Haiyang Liang ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Cell Cycle Progression ◽  
Luciferase Reporter ◽  
Cell Behaviors ◽  
Prokineticin 2 ◽  
Glioma Cell Lines ◽  
Glioma Cell Proliferation ◽  
Cancer Types

MicroRNA-374a has been abnormally expressed in several cancer types; however, its role in glioma remains unclear. Therefore, we aimed to investigate whether microR-374a participated in the progression of glioma. Expression of microR-374a in glioma cell lines and normal cell line was measured by quantitative real-time polymerase chain reaction. Luciferase reporter assay and Western blot were used to detect the targets of microR-374a. In vitro functional experiments were conducted to investigate the biological role of microR-374a. Low expression of microR-374a was found in glioma cell lines. Prokineticin 2 was identified as a direct target of microR-374a in glioma. Investigations on the mechanisms related to glioma progression showed that microR-374a inhibited glioma cell proliferation, cell cycle progression, and cell invasion through targeting Prokineticin 2. Taken together, these results revealed that microR-374a functions as tumor suppressor by targeting Prokineticin 2, suggesting it might be a novel therapeutic target for glioma.

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