Tumor location-based classification of surgery-related language impairments in patients with glioma

2021 ◽  
Author(s):  
Shengyu Fang ◽  
Yuchao Liang ◽  
Lianwang Li ◽  
Lei Wang ◽  
Xing Fan ◽  
...  
Keyword(s):  
Tumor Location ◽  
Language Impairments ◽  
Related Language

scholarly journals Classification of Surgery-Related Language Impairments in Patients with Glioma Based on Tumor Locations

2021 ◽  
Author(s):  
Shengyu Fang ◽  
Yuchao Liang ◽  
Lianwang Li ◽  
Lei Wang ◽  
Xing Fan ◽  
...  
Keyword(s):  
Language Impairment ◽  
Tumor Resection ◽  
Tumor Location ◽  
Language Impairments ◽  
Precentral Gyrus ◽  
Type Ii ◽  
Arcuate Fasciculus ◽  
Supramarginal Gyrus ◽  
Superior Longitudinal Fasciculus ◽  
Related Language

Abstract IntroductionMany patients with glioma experience surgery-related language impairment. This study developed a classification system to predict postoperative language prognosis.MethodsSixty-eight patients were retrospectively reviewed. Based on their location, tumors were subtyped as follows: I) inferior frontal lobe or precentral gyrus; II) posterior central gyrus or supramarginal gyrus (above the lateral fissure level); III) posterior region of the superior or middle temporal gyri or supramarginal gyrus (below the lateral fissure level); and IV) insular lobe. The distance from the tumor to the superior longitudinal fasciculus/arcuate fasciculus was calculated. The recovery of language function was assessed using the Western Aphasia Battery before surgery, and a comprehensive language test was conducted on the day of surgery; 3, 7, and 14 days later, and 3 months later.ResultsThirty-three patients experienced transient language impairment within 1 week of surgery. Fourteen patients had permanent language impairment. Type II tumors, shorter distance from the tumor to the posterior superior longitudinal fasciculus/arcuate fasciculus, and isocitrate dehydrogenase mutations were risk factors for surgery-related language impairment. Regarding the presence or absence of permanent surgery-related language impairments, the cut-off distance between the tumor and posterior superior longitudinal fasciculus/arcuate fasciculus was 2.75 mm.ConclusionsAccording to our classification, patients with type II tumors had the worst language prognosis and longest recovery time. Our classification, which is based on tumor location, can reliably predict postoperative language status and may be used to guide tumor resection.

scholarly journals NIMG-53. GLUTAMATE/GABA RATIO ON MRS IS ELEVATED IN PATIENTS WITH LOWER GRADE GLIOMAS AND SEIZURES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii159-ii160
Author(s):  
Roberta Rudà ◽  
Riccardo Pascuzzo ◽  
Francesca Mo ◽  
Alessia Pellerino ◽  
Peter B Barker ◽  
...  
Keyword(s):  
Tumor Location ◽  
Resonance Spectroscopy ◽  
Lower Grade ◽  
Lack Of Information ◽  
Baseline Evaluation ◽  
Grade Ii ◽  
Grade Iii

Abstract BACKGROUND There is lack of information on the role of excitatory and inhibitory neurotransmitters in the development of seizures in patients with lower grade gliomas. Increase of glutamate and downregulation of GABA have been suggested in preclinical models and human surgical samples to be associated with brain tumor-related epilepsy. MATERIAL AND METHODS We prospectively investigated with the use of magnetic resonance spectroscopy (MRS) the differences in the ratio of metabolites (glutamate/GABA, glutamate/creatine and GABA/creatine) in the peritumoral areas between patients with or without seizures in a series of lower grade gliomas. Tumors were classified according to WHO Classification of 2016 as follows:11 grade II IDH mutated and 1p/19q codeleted; 3 grade III IDH mutated and 1p/19q codeleted; 6 grade II IDH mutated and 1p/19q intact; 1 grade III IDH mutated and 1p/19q intact; 1 grade II IDH wild-type. Patients received surgery alone or followed by temozolomide chemotherapy according to the presence of risk factors. RESULTS At baseline evaluation, maximum glutamate/GABA values were significantly higher (p=0.023) in the peritumoral area of patients with seizures (1.008 ± 0.368) with respect to those without seizures (0.691 ± 0.170). No other metabolites ratio showed significant differences between the two groups. Similar results were obtained when analyzing the metabolites ratio in the examinations during the follow-up. In the cohort of patients with seizures (n.14) variations of metabolite ratios were not associated with tumor location, 1p/19q codeletion, use of AEDs, concomitant chemotherapy or seizure characteristics (type, duration, frequency). CONCLUSIONS The study is ongoing with the aim of analyzing further the correlations between ratio of metabolites and status of the tumor (stable vs progressive).

Ocular Melanoma

2010 ◽  
Vol 134 (12) ◽  
pp. 1778-1784
Author(s):  
Nora V. Laver ◽  
Margaret E. McLaughlin ◽  
Jay S. Duker
Keyword(s):  
Metastatic Disease ◽  
Needle Aspiration ◽  
Tumor Location ◽  
Local Tumor Control ◽  
Treatment Modalities ◽  
Tumor Control ◽  
The Novel ◽  
Risk Of Death ◽  
Melanocytic Lesions

Abstract Context—Intraocular melanoma of the ciliary body and choroid is the most common primary ocular malignant tumor in adults and the most common noncutaneous melanoma. Objective—To describe the most salient clinical features, histopathologic findings, and treatment modalities of intraocular melanoma, as well as the novel therapies currently being tested. Data Sources—Clinically, it is important to determine which lesions carry a worse prognosis so as to offer patients the best treatment modalities available. Tumor location, size, histopathology, cytogenetic abnormalities, and tumor profiling are all used in determining the risk of death from metastatic disease of uveal melanocytic lesions. Despite successful local tumor control, up to 50% of patients have metastatic disease within 15 years of diagnosis; there is no effective treatment for metastatic disease. Conclusions—Pathologists should be aware of the importance of tumor gross description, cellular histopathology classification, the use of fine-needle aspiration biopsy coupled with cytogenetics, and the new classification of uveal malignant melanomas that is based on chromosome 3 status.

scholarly journals Localized, Plexiform, Diffuse, and Other Variants of Neurofibroma in 12 Dogs, 2 Horses, and a Chicken

2009 ◽  
Vol 46 (5) ◽  
pp. 904-915 ◽  
Author(s):  
S. Schöniger ◽  
B. A. Summers
Keyword(s):  
Peripheral Nerve ◽  
Large Intestine ◽  
Tumor Location ◽  
Growth Patterns ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Microscopic Features ◽  
Canine Tumors

In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors. In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established. We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken. Dogs were of different breeds and were aged 2 months to 15 years. The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine. The 2 horses were 11 and 12 years old. The equine tumors were located in the subcutis of the neck and axilla. The chicken was a mature white Leghorn chicken with an ocular neoplasm. Neurofibromas of this study had localized, plexiform, diffuse and combined plexiform and diffuse growth patterns, and microscopic features similar to those in classic, collagenous, cellular, myxoid, and pigmented neurofibromas of humans. One diffuse neurofibroma contained areas of schwannian differentiation (hybrid neurofibroma-schwannoma). Two plexiform neurofibromas occurred together with diffuse ganglioneuromatosis in the large intestine of young dogs, as has also been reported in humans. This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans. This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

Acupuncture as a Treatment Technique for Aphasia and Cognitive Impairments

2008 ◽  
Vol 18 (3) ◽  
pp. 107-113 ◽  
Author(s):  
Jacqueline Laures-Gore ◽  
Rebecca Shisler Marshall
Keyword(s):  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Empirical Evidence ◽  
Cognitive Impairments ◽  
Language Impairments ◽  
Treatment Technique ◽  
Speech Language Pathologists ◽  
Valuable Adjunct ◽  
Related Language ◽  
Effective Treatments

Abstract Purpose: In response to the growing interest and use of acupuncture by Americans who are searching for effective treatments of aphasia and cognitive impairments, this paper serves to (a) briefly explain the technique of acupuncture, (b) describe its biologic mechanisms, and (c) summarize studies investigating the effectiveness of acupuncture in treating cognitive impairment associated with vascular dementia and stroke-related language impairments. Methods: Published reports of the use and effectiveness of acupuncture in treating cognitive impairments related to vascular dementia and aphasia related to stroke are reviewed and reported. Results and Conclusions: Rigorously designed studies investigating acupuncture and vascular neuropathologies are too few in number to produce any definite conclusions about the efficacy of this technique in treating aphasia related to stroke or cognitive impairments related to vascular dementia. Although there is some empirical evidence indicating that acupuncture may be a valuable adjunct to conventional therapies, speech-language pathologists should remain cautious of acupuncture's promise until further, well-designed studies are conducted.

scholarly journals Considerations about gastric cancer proteomics

2016 ◽  
Vol 43 (5) ◽  
pp. 395-397 ◽  
Author(s):  
CARLOS EDUARDO CARVALHO ◽  
THAÍS MESSIAS MCCORMICK ◽  
PAULO COSTA CARVALHO ◽  
JULIANA DE SALDANHA DA GAMA FISCHER ◽  
PRISCILA FERREIRA DE AQUINO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Classification ◽  
Tumor Location ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Cancer Proteomics ◽  
Different Types ◽  
Epstein Barr ◽  
Barr Virus Infection

ABSTRACT The frequency of molecular studies aimed to analyze promoter methylation of tumor suppressor genes and global proteomics in gastric carcinogenesis is increasing. Nonetheless, only a few considered the different types of stomach cells, the tumor location and the influence of Helicobacter pylori and Epstein Barr virus infection (EBV). Molecular differences relating to anatomical and histological tumor areas were also recently described. The authors propose a molecular classification of gastric cancer, dividing it into four subtypes: tumors positive for EBV; microsatellite unstable tumors; genomically stable tumors and tumors with chromosomal instability.

Clinical and Research Congruence in Identifying Children With Specific Language Impairment

1993 ◽  
Vol 36 (3) ◽  
pp. 580-591 ◽  
Author(s):  
Dorothy M. Aram ◽  
Robin Morris ◽  
Nancy E. Hall
Keyword(s):  
Language Impairment ◽  
Specific Language Impairment ◽  
Professional Training ◽  
Language Impairments ◽  
Specific Language ◽  
Research Activities ◽  
Specific Language Impairments ◽  
Assessment Measures ◽  
Operational Criteria

This paper reports on the results of a large multicenter project designed to develop an empirically based classification of preschool children with language impairments. A clinically selected population of 252 children with specific language impairments (SLI) was used to evaluate the reliability, coverage, and usefulness of both standard clinical and research definitions of such children. Varying degrees of congruence were found between the clinically identified children with SLI and those identified as SLI using discrepancy, deficit, and standardized operational criteria. Such mismatch between the original clinical identification and more standardized operational criteria may be related to different clinical perspectives, professional training, and limited assessment measures. These results suggest that there is a significant gulf between the clinical diagnosis of children with specific language impairment and more standardized operational criteria. It is suggested that the global concept of a “specific language impairment” may not be a useful concept for either clinical or research activities.

Note on the spectral classification of carbon stars in the photographic infrared region

1966 ◽  
Vol 24 ◽  
pp. 21-23
Author(s):  
Y. Fujita
Keyword(s):  
Infrared Region ◽  
Spectral Classification ◽  
Carbon Stars

We have investigated the spectrograms (dispersion: 8Å/mm) in the photographic infrared region fromλ7500 toλ9000 of some carbon stars obtained by the coudé spectrograph of the 74-inch reflector attached to the Okayama Astrophysical Observatory. The names of the stars investigated are listed in Table 1.

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