scholarly journals A new principle of plural harm

Author(s):  
Magnus Jedenheim Edling
Keyword(s):  
Do So ◽  

AbstractAccording to the counterfactual comparative account (CCA), an event harms a person if and only if it makes things worse for her. Cases of overdetermination and preemption pose a serious challenge to CCA since, in these cases, although it is evident that people are harmed, there are no individual events that harm them. However, while there are no individual events that make people worse off in cases of overdetermination and preemption, there are pluralities of events that do so. In light of this feature of these cases, several philosophers have suggested that it is these pluralities that do the harming. In this article, I will argue that although the most prominent accounts of plural harm – e.g., Neil Feit’s account – fare better than one might initially think, they fail to deal adequately with a number of intriguing cases of preemption first introduced by Alastair Norcross. I will also introduce a new view on plural harm and argue that this view, apart from dealing with the cases of overdetermination and preemption that the other accounts of plural harm handle, also deals adequately with Norcross’s cases.


Author(s):  
Scott Aikin

If you believe something rationally, you believe it for a reason. And that reason can’t just be any old reason. You’ve got to rationally hold it as a good reason. In order to do so, you must have another reason. And that reason needs another. And so a regress of reasons ensues. This is a rough-and-ready picture of the epistemic regress problem. Epistemic infinitism is the view that justifying reasons are infinite, and so it is a particular solution to the regress problem. Consider, also, that justification comes in degrees – some beliefs are better justified than others. Moreover, it seems that people can know things better than others. Call this the gradability phenomenon. Epistemic infinitism is the view that for someone to be justified maximally is for that person to have an infinite series of supporting reasons. Epistemic infinitisms admit of a wide variety. Differences between versions of infinitism arise according to two factors for the view: one dialectical, the other ecumenical. The dialectical factor for epistemic infinitisms is the matter of what philosophical problems or questions they answer. Infinitisms are designed to either provide models for how to solve the epistemic regress problem or address the phenomenon of the gradability of justification and knowledge. Infinitisms will differ depending on which issue they are designed to address, and an infinitism designed to address one issue may not be the same as one designed to address another. The ecumenical factor for epistemic infinitisms is the matter of how consistent the view is with other competing theories about how to address the regress problem and the gradability phenomenon. With the regress problem, infinitism’s main competitor theories are foundationalism, the view that there are basic beliefs for which there is no need for further reason, and coherentism, the view that justifying reasons come in large mutually supporting packages. For the most part, infinitism is taken to be a form of noncoherentist antifoundationalism about justification, because the infinitist holds that reasons must be infinitely long chains of nonrepeating reasons. However, there are versions of infinitism consistent with both foundationalism and coherentism. Infinitism faces a variety of challenges, and two of particular importance are whether infinitism is actually a form of scepticism and whether infinitism is a complete theory of justification.



2019 ◽  
Vol 36 (8) ◽  
pp. 669-674 ◽  
Author(s):  
Holly B. Cunningham ◽  
Shannon A. Scielzo ◽  
Paul A. Nakonezny ◽  
Brandon R. Bruns ◽  
Karen J. Brasel ◽  
...  

Background: The value of defining goals of care (GoC) for geriatric patients is well known to the palliative care community but is a newer concept for many trauma surgeons. Palliative care specialists and trauma surgeons were surveyed to elicit the specialties’ attitudes regarding (1) importance of GoC conversations for injured seniors; (2) confidence in their own specialty’s ability to conduct these conversations; and (3) confidence in the ability of the other specialty to do so. Methods: A 13-item survey was developed by the steering committee of a multicenter, palliative care-focused consortium and beta-tested by trauma surgeons and palliative care specialists unaffiliated with the consortium. The finalized instrument was electronically circulated to active physician members of the American Association for the Surgery of Trauma and American Academy for Hospice and Palliative Medicine. Results: Respondents included 118 trauma surgeons (8.8%) and 244 palliative care specialists (5.7%). Palliative physicians rated being more familiar with GoC, were more likely to report high-quality training in performing conversations, believed more palliative specialists were needed in intensive care units, and had more interest in conducting conversations relative to trauma surgeons. Both groups believed themselves to perform GoC discussions better than the other specialty perceived them to do so and favored their own specialty leading team discussions. Conclusions: Both groups believe themselves to conduct GoC discussions for injured seniors better than the other specialty perceived them to do so, which led to disparate views on the optimal leadership of these discussions.



2017 ◽  
Vol 61 (2) ◽  
pp. 173-198 ◽  
Author(s):  
Yevgeniy Vasilyevich Melguy

It is well known that the way monolingual listeners discriminate speech sounds is strongly influenced by their native (L1) sound system. Moreover, such perceptual constraints are not limited to monolinguals: multiple studies have found evidence of language-specificity in bilingual speech perception. However, the question of whether bilinguals have simultaneous access to both of their phonologies during non-native contrast discrimination has not been systematically examined. Namely, very few studies of bilinguals have specifically examined cases where a non-native contrast pair straddles the boundary between two sound systems, with one sound corresponding to a sound in the L1, and the other to a sound in the second language (L2), but with neither the L1 nor the L2 containing both. The current study aimed to do so by comparing the ability of early bilinguals to discriminate non-native phonetic contrasts consisting of sounds that exist in either their L1 or L2, but not in both. A forced-choice perception task compared two listener groups—Spanish–English bilinguals and English monolinguals—on their perception of Nepali dental–alveolar stop contrasts. Results showed that despite displaying some sensitivity to phonetic differences within each contrast pair, the bilingual group was unable to discriminate such “cross-language contrasts” significantly better than the monolingual English control group.



Author(s):  
A. V. Crewe

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.



2020 ◽  
Vol 15 (2) ◽  
pp. 379-403
Author(s):  
Roudhotul Jannah

This article is about Angelika Neuwirth’s thought, dialectical of Qur’anic interpretation. She offer new view to understanding of Qur’an’s meaning. Neuwirth encourage to reunderstanding Qur’an post-canonization (a written text) with pre-canonization method (oral communication), as in Surat Al-Ikhlas. Accourding Neuwirth, Surat Al-Ikhlas responded from tradition and civilization of Arabic region earlier. An example أَحَدٌ (Q.112:1) is similiar meaning with “ehad” in Ibrani language. That’s mean usage أَحَدٌ had purpose to negotiation strategy and universality of faith. therefore Islamic religion has mission to combine all ideology of faith become unity universality. Neuwirth encourages to refer to the other holy scripture for adding comprehensive information and objective data.



Imbizo ◽  
2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Naomi Epongse Nkealah ◽  
Olutoba Gboyega Oluwasuji

Ideas of nationalisms as masculine projects dominate literary texts by African male writers. The texts mirror the ways in which gender differentiation sanctions nationalist discourses and in turn how nationalist discourses reinforce gender hierarchies. This article draws on theoretical insights from the work of Anne McClintock and Elleke Boehmer to analyse two plays: Zintgraff and the Battle of Mankon by Bole Butake and Gilbert Doho and Hard Choice by Sunnie Ododo. The article argues that women are represented in these two plays as having an ambiguous relationship to nationalism. On the one hand, women are seen actively changing the face of politics in their societies, but on the other hand, the means by which they do so reduces them to stereotypes of their gender.



Author(s):  
Maxim B. Demchenko ◽  

The sphere of the unknown, supernatural and miraculous is one of the most popular subjects for everyday discussions in Ayodhya – the last of the provinces of the Mughal Empire, which entered the British Raj in 1859, and in the distant past – the space of many legendary and mythological events. Mostly they concern encounters with inhabitants of the “other world” – spirits, ghosts, jinns as well as miraculous healings following magic rituals or meetings with the so-called saints of different religions (Hindu sadhus, Sufi dervishes),with incomprehensible and frightening natural phenomena. According to the author’s observations ideas of the unknown in Avadh are codified and structured in Avadh better than in other parts of India. Local people can clearly define if they witness a bhut or a jinn and whether the disease is caused by some witchcraft or other reasons. Perhaps that is due to the presence in the holy town of a persistent tradition of katha, the public presentation of plots from the Ramayana epic in both the narrative and poetic as well as performative forms. But are the events and phenomena in question a miracle for the Avadhvasis, residents of Ayodhya and its environs, or are they so commonplace that they do not surprise or fascinate? That exactly is the subject of the essay, written on the basis of materials collected by the author in Ayodhya during the period of 2010 – 2019. The author would like to express his appreciation to Mr. Alok Sharma (Faizabad) for his advice and cooperation.



HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 452c-452 ◽  
Author(s):  
Schuyler D. Seeley ◽  
Raymundo Rojas-Martinez ◽  
James Frisby

Mature peach trees in pots were treated with nighttime temperatures of –3, 6, 12, and 18 °C for 16 h and a daytime temperature of 20 °C for 8 h until the leaves abscised in the colder treatments. The trees were then chilled at 6 °C for 40 to 70 days. Trees were removed from chilling at 40, 50, 60, and 70 days and placed in a 20 °C greenhouse under increasing daylength, spring conditions. Anthesis was faster and shoot length increased with longer chilling treatments. Trees exposed to –3 °C pretreatment flowered and grew best with 40 days of chilling. However, they did not flower faster or grow better than the other treatments with longer chilling times. There was no difference in flowering or growth between the 6 and 12 °C pretreatments. The 18 °C pretreatment resulted in slower flowering and very little growth after 40 and 50 days of chilling, but growth was comparable to other treatments after 70 days of chilling.



2020 ◽  
Vol 27 (3) ◽  
pp. 178-186 ◽  
Author(s):  
Ganesan Pugalenthi ◽  
Varadharaju Nithya ◽  
Kuo-Chen Chou ◽  
Govindaraju Archunan

Background: N-Glycosylation is one of the most important post-translational mechanisms in eukaryotes. N-glycosylation predominantly occurs in N-X-[S/T] sequon where X is any amino acid other than proline. However, not all N-X-[S/T] sequons in proteins are glycosylated. Therefore, accurate prediction of N-glycosylation sites is essential to understand Nglycosylation mechanism. Objective: In this article, our motivation is to develop a computational method to predict Nglycosylation sites in eukaryotic protein sequences. Methods: In this article, we report a random forest method, Nglyc, to predict N-glycosylation site from protein sequence, using 315 sequence features. The method was trained using a dataset of 600 N-glycosylation sites and 600 non-glycosylation sites and tested on the dataset containing 295 Nglycosylation sites and 253 non-glycosylation sites. Nglyc prediction was compared with NetNGlyc, EnsembleGly and GPP methods. Further, the performance of Nglyc was evaluated using human and mouse N-glycosylation sites. Results: Nglyc method achieved an overall training accuracy of 0.8033 with all 315 features. Performance comparison with NetNGlyc, EnsembleGly and GPP methods shows that Nglyc performs better than the other methods with high sensitivity and specificity rate. Conclusion: Our method achieved an overall accuracy of 0.8248 with 0.8305 sensitivity and 0.8182 specificity. Comparison study shows that our method performs better than the other methods. Applicability and success of our method was further evaluated using human and mouse N-glycosylation sites. Nglyc method is freely available at https://github.com/bioinformaticsML/ Ngly.



2019 ◽  
Vol 15 (5) ◽  
pp. 472-485 ◽  
Author(s):  
Kuo-Chen Chou ◽  
Xiang Cheng ◽  
Xuan Xiao

<P>Background/Objective: Information of protein subcellular localization is crucially important for both basic research and drug development. With the explosive growth of protein sequences discovered in the post-genomic age, it is highly demanded to develop powerful bioinformatics tools for timely and effectively identifying their subcellular localization purely based on the sequence information alone. Recently, a predictor called “pLoc-mEuk” was developed for identifying the subcellular localization of eukaryotic proteins. Its performance is overwhelmingly better than that of the other predictors for the same purpose, particularly in dealing with multi-label systems where many proteins, called “multiplex proteins”, may simultaneously occur in two or more subcellular locations. Although it is indeed a very powerful predictor, more efforts are definitely needed to further improve it. This is because pLoc-mEuk was trained by an extremely skewed dataset where some subset was about 200 times the size of the other subsets. Accordingly, it cannot avoid the biased consequence caused by such an uneven training dataset. </P><P> Methods: To alleviate such bias, we have developed a new predictor called pLoc_bal-mEuk by quasi-balancing the training dataset. Cross-validation tests on exactly the same experimentconfirmed dataset have indicated that the proposed new predictor is remarkably superior to pLocmEuk, the existing state-of-the-art predictor in identifying the subcellular localization of eukaryotic proteins. It has not escaped our notice that the quasi-balancing treatment can also be used to deal with many other biological systems. </P><P> Results: To maximize the convenience for most experimental scientists, a user-friendly web-server for the new predictor has been established at http://www.jci-bioinfo.cn/pLoc_bal-mEuk/. </P><P> Conclusion: It is anticipated that the pLoc_bal-Euk predictor holds very high potential to become a useful high throughput tool in identifying the subcellular localization of eukaryotic proteins, particularly for finding multi-target drugs that is currently a very hot trend trend in drug development.</P>



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