Assessment of provider practices regarding venous thromboembolism management and prevention in pediatric acute leukemia patients

2021 ◽  
Author(s):  
Melanie Degliuomini ◽  
Victoria Cooley ◽  
Elizabeth Mauer ◽  
Linda M. Gerber ◽  
Suchitra Acharya ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Provider Practices

scholarly journals Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival

Blood ◽  
2009 ◽  
Vol 113 (17) ◽  
pp. 3911-3917 ◽  
Author(s):  
Grace H. Ku ◽  
Richard H. White ◽  
Helen K. Chew ◽  
Danielle J. Harvey ◽  
Hong Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Lymphoblastic Leukemia ◽  
Venous Catheter ◽  
Population Based ◽  
Older Age ◽  
Myelogenous Leukemia ◽  
Vein Thrombosis ◽  
Chronic Comorbidities

Abstract A population-based cohort was used to determine the incidence and risk factors associated with development of venous thromboembolism (VTE) among Californians diagnosed with acute leukemia between 1993 to 1999. Principal outcomes were deep vein thrombosis in both the lower and upper extremities, pulmonary embolism, and mortality. Among 5394 cases with acute myelogenous leukemia (AML), the 2-year cumulative incidence of VTE was 281 (5.2%). Sixty-four percent of the VTE events occurred within 3 months of AML diagnosis. In AML patients, female sex, older age, number of chronic comorbidities, and presence of a catheter were significant predictors of development of VTE within 1 year. A diagnosis of VTE was not associated with reduced survival in AML patients. Among 2482 cases with acute lymphoblastic leukemia (ALL), the 2-year incidence of VTE in ALL was 4.5%. Risk factors for VTE were presence of a central venous catheter, older age, and number of chronic comorbidities. In the patients with ALL, development of VTE was associated with a 40% increase in the risk of dying within 1 year. The incidence of VTE in acute leukemia is appreciable, and is comparable with the incidence in many solid tumors.

Impact of number of lumens in central-venous catheters on central-line bloodstream infection (CLABSI) and venous thromboembolism (VTE) risk in patients with acute leukemia

2021 ◽  
pp. 1-3
Author(s):  
Alina Varabyeva ◽  
Christabel Pui-See Lo ◽  
Adamo Brancaccio ◽  
Anthony J. Perissinotti ◽  
Twisha Patel ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Bloodstream Infections ◽  
Central Line ◽  
Central Venous Catheters ◽  
Peripherally Inserted Central Catheter ◽  
Central Catheter ◽  
Central Venous ◽  
Double Lumen

Abstract This retrospective study was conducted to determine whether the number of peripherally inserted central-catheter lumens affected the rate of central-line associated bloodstream infections (CLABSIs) in adult patients with acute leukemia. The results show that CLABSI rates were not significantly different between patients with triple-lumen or double-lumen PICCs (22.1% vs 23.4%; P = .827).

scholarly journals A retrospective study of venous thromboembolism in acute leukemia patients treated at the University of Texas MD Anderson Cancer Center

2014 ◽  
Vol 4 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Khanh Vu ◽  
Nhiem V. Luong ◽  
Julie Hubbard ◽  
Ali Zalpour ◽  
Stefan Faderl ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Cancer Center ◽  
University Of Texas ◽  
Md Anderson ◽  
The University

Management of venous thromboembolism in patients with acute leukemia at high bleeding risk: a multi-center study

2015 ◽  
Vol 57 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Mariasanta Napolitano ◽  
Luca Valore ◽  
Alessandra Malato ◽  
Giorgia Saccullo ◽  
Calogero Vetro ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Bleeding Risk ◽  
Multi Center Study ◽  
High Bleeding Risk ◽  
Center Study

Treatment of venous thromboembolism in acute leukemia: A systematic review

2019 ◽  
Vol 178 ◽  
pp. 1-6 ◽  
Author(s):  
Azin Ahrari ◽  
Fatimah Al-Ani ◽  
Yimin Pearl Wang ◽  
Alejandro Lazo-Langner
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Acute Leukemia

Development of a Clinical Prediction Rule for Venous Thromboembolism in Patients with Acute Leukemia

2020 ◽  
Vol 120 (02) ◽  
pp. 322-328 ◽  
Author(s):  
Fatimah Al-Ani ◽  
Yimin Pearl Wang ◽  
Alejandro Lazo-Langner
Keyword(s):  
Venous Thromboembolism ◽  
Acute Leukemia ◽  
Risk Group ◽  
Lymphoblastic Leukemia ◽  
Care Center ◽  
Tertiary Care ◽  
Previous History ◽  
Prediction Rule ◽  
High Risk Group ◽  
Predictive Score

AbstractRisk factors for venous thromboembolism in patients with solid tumors are well studied; however, studies in patients with acute leukemia are lacking. We conducted a retrospective cohort study of adult patients diagnosed with acute myeloid leukemia and acute lymphoblastic leukemia diagnosed between June 2006 and June 2017 at a tertiary care center in Canada. Potential predictors of venous thromboembolism were evaluated using logistic regression and a risk score was derived based on weighed variables and compared using survival analysis. Internal validation was conducted using nonparametric bootstrapping. A total of 501 leukemia patients (427 myeloid and 74 lymphoblastic) were included. Venous thromboembolism occurred in 77(15.3%) patients with 71 events occurring in the first year. A prediction score was derived and validated and it included: previous history of venous thromboembolism (3 points), lymphoblastic leukemia (2 points), and platelet count > 50 × 109/L at the time of diagnosis (1 point). The overall cumulative incidence of venous thromboembolism was 44% in the high-risk group (≥ 3 points) versus 10.5% in the low-risk group (0–2 points) and it was consistent at different follow-up periods (log-rank p < 0.001). We derived and internally validated a predictive score of venous thromboembolism risk in acute leukemia patients.

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