Relationship of adiponectin to markers of oxidative stress in type 2 diabetic patients: influence of incipient diabetes-associated kidney disease

2015 ◽  
Vol 47 (7) ◽  
pp. 1173-1180 ◽  
Author(s):  
Cosmina Ioana Bondor ◽  
Alina Ramona Potra ◽  
Diana Moldovan ◽  
Crina Claudia Rusu ◽  
Mariana Ciorba Pop ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Markers Of Oxidative Stress ◽  
Relationship Of ◽  
Type 2 Diabetic

Markers of Oxidative Stress in the Saliva of Type 2 Diabetic Patients

2021 ◽  
Vol 7 (2) ◽  
pp. 1-4
Author(s):  
Olatunde Olayanju ◽  
Victory Edem ◽  
Chika Okwor ◽  
Gabriel Odok ◽  
Nnaemeka Awah
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Diabetic Patients ◽  
Oral Diseases ◽  
Operating Characteristics ◽  
Type 2 Diabetic Patients ◽  
Markers Of Oxidative Stress ◽  
Type 2 Diabetic

Objective: Diabetes mellitus is associated with increased prevalence of oral diseases for which reactive oxygen species have been implicated. The saliva contains protective antioxidants which statutorily curtail these destructive oxygen molecules. A functional compromise of the antioxidants may precipitate oxidative stress leading to the increased oral disease susceptibility. However, salivary markers of oxidative stress have not been sufficiently studied in the diabetics. Methods: A total of 166 adults were recruited for this study. They comprised of 95 Type 2 diabetic patients and 71 healthy non-diabetic controls. About 3 ml of unstimulated saliva samples were collected from participants and processed, levels of salivary H2O2, NO and MDA were measured using spectrophotometry method and compared between the two groups. Data was analysed using t-test, logistic regression and receiver operating characteristics (ROC) with statistical significance set at p<0.05. Results: Salivary H2O2 (p=0.024) and NO (p=0.002) were significantly higher in the diabetic patients when compared to the healthy non-diabetic control group. Binary logistic regression showed that patients with Type 2 diabetic mellitus are more likely to have elevated salivary H2O2 (OR= 1.013; p=0.025) and NO (OR=1.016; p=0.003) levels. ROC analysis showed statistically significant performance of salivary NO levels in distinguishing between T2DM patients and healthy controls. Conclusions: Higher levels of oxidative stress markers including salivary H2O2 and NO in the diabetic groups could be a pointer to the characteristic high prevalence of oral diseases in diabetes mellitus, given that oxidative stress predisposes to disease vulnerability. This calls for increased attention to oral health in diabetes management to minimise co-morbidity.

Markers of Oxidative Stress in the Saliva of Type 2 Diabetic Patients (Preprint)

2020 ◽  
Author(s):  
Olatunde Olayanju ◽  
Chika Juiet Okwor ◽  
Gabriel Nku Odok Jr ◽  
Gabriel Nku Odok Jr ◽  
Nnaemeka Elvis Awah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Reactive Oxygen Species ◽  
Diabetic Patients ◽  
Oxygen Species ◽  
Oral Diseases ◽  
Type 2 Diabetic Patients ◽  
Markers Of Oxidative Stress ◽  
Type 2 Diabetic

BACKGROUND Diabetes mellitus is associated with increased prevalence of oral diseases. Reactive oxygen species have been implicated in the development of these diseases. The saliva contains a balanced proportion of protective antioxidants and reactive oxygen species, disrupting this balance favours disease development. However, level of salivary markers of oxidative stress has not been sufficiently studied in the diabetics. OBJECTIVE Thus, this study aimed to measure salivary H2O2, NO and MDA in diabetic patients in comparison to non-diabetic controls. METHODS A total of 166 adults comprising of 95 Type 2 diabetic patients and 71 healthy non-diabetic controls were recruited for this study. About 3 ml of unstimulated saliva samples were collected from participants after rinsing their mouth with clean water. Levels of H2O2, NO and MDA were measured in all saliva samples using spectrophotometry. Data was analysed using t-test, logistic regression and receiver operating characteristics (ROC) with statistical significance set at p<0.05. RESULTS Salivary H2O2 (p=0.024) and NO (p=0.002) were significantly higher in the diabetic patients when compared to the healthy non-diabetic control group. Binary logistic regression showed that patients with Type 2 diabetic mellitus are more likely to have elevated salivary H2O2 (OR= 1.013; p=0.025) and NO (OR=1.016; p=0.003) levels. ROC analysis showed statistically significant performance of salivary NO levels in distinguishing between T2DM patients and healthy controls. CONCLUSIONS Higher levels of salivary H2O2 and NO could be a pointer to the high prevalence of oral diseases in diabetes mellitus. This calls for increased attention to oral health in diabetes management.

scholarly journals Glycaemic control in type 2 diabetic patients with chronic kidney disease: the impacts on enzymatic antioxidants and soluble RAGE

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4421 ◽  
Author(s):  
Foo Nian Wong ◽  
Kek Heng Chua ◽  
Jin Ai Mary Anne Tan ◽  
Chew Ming Wong ◽  
Umah Rani Kuppusamy
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Glycaemic Control ◽  
Diabetic Patients ◽  
Enzymatic Antioxidants ◽  
Type 2 Diabetic Patients ◽  
Soluble Rage ◽  
Study Participants ◽  
Type 2 Diabetic

Background Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development and progression of the disease. Glycaemic control slows down the progression of diabetic complications, including diabetic CKD. However, the implication of glycaemic control on enzymatic antioxidants and soluble RAGE (sRAGE) in CKD patients remains elusive. The aim of this study was to investigate the effect of glycaemic control on the levels or activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and sRAGE in CKD patients. Methods A total of 150 CKD patients and 64 non-CKD patients were enrolled. The type 2 diabetic patients in the recruited study participants were categorised based on their glycaemic control; poor glycaemic control (GC) with haemoglobin A1c (HbA1c) > 7% and good GC with HbA1c ≤ 7%. The levels or activities of GPx, SOD and sRAGE in plasma were measured. These biochemical parameters were analysed using Mann–Whitney U test and two-way analysis of variance (ANOVA). Results The activities of GPx and SOD as well as plasma level of sRAGE were not significantly different among the CKD patients with varying glycaemic control status. Irrespective of diabetes status and glycaemic control status, CKD patients also exhibited lower plasma SOD activities compared with non-CKD patients. Among the non-CKD patients, SOD activities were significantly higher in diabetic patients with good GC than diabetic patients with poor GC. Two-way ANOVA revealed that both CKD status and glycaemic control had an interaction effect on SOD activities in diabetic subjects with and without CKD. Follow-up analysis showed that SOD activities were significantly higher in non-CKD patients with good GC. There were no overall significant differences in GPx activities among the study participants. Furthermore, plasma sRAGE levels were higher in diabetic patients with CKD than those without CKD, regardless of glycaemic control status. There were no interaction effects between CKD status and glycaemic control status on GPx and sRAGE. Instead, CKD status showed significant main effects on these parameters, indicating significant differences between diabetic subjects with CKD and diabetic subjects without CKD. Conclusion Glycaemic control did not quantitatively alter GPx, SOD and sRAGE in diabetic CKD patients. Despite the advantages of good glycaemic control, a well-controlled diabetes in CKD did not modulate the activities of enzymatic antioxidants and sRAGE levels, therefore may not be the primary mechanism to handle oxidative stress.

539-P: The Trend of Diabetic Kidney Disease with Low eGFR and Absence of Albuminuria in Type 2 Diabetic Patients in Japan from 1996-2015

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 539-P
Author(s):  
YOSHINORI KAKUTANI ◽  
MASANORI EMOTO ◽  
KATSUHITO MORI ◽  
YUKO YAMAZAKI ◽  
AKINOBU OCHI ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetic Kidney ◽  
Type 2 Diabetic

Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

2016 ◽  
Vol 22 (18) ◽  
pp. 2650-2656 ◽  
Author(s):  
Noelia Diaz-Morales ◽  
Susana Rovira-Llopis ◽  
Irene Escribano-Lopez ◽  
Celia Bañuls ◽  
Sandra Lopez-Domenech ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals POS-364 TO STUDY THE CLINICAL PHENOTYPE OF NON - PROTEINURIC KIDNEY DISEASE IN TYPE 2 DIABETIC PATIENTS

2021 ◽  
Vol 6 (4) ◽  
pp. S158
Author(s):  
R.K. YADAV ◽  
S. Sangha ◽  
A. S Kumar ◽  
S. Bagchi ◽  
S. Mahajan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Clinical Phenotype ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Soy Milk Consumption, Inflammation, Coagulation, and Oxidative Stress Among Type 2 Diabetic Patients With Nephropathy

Diabetes Care ◽  
2012 ◽  
Vol 35 (10) ◽  
pp. 1981-1985 ◽  
Author(s):  
M. S. Miraghajani ◽  
A. Esmaillzadeh ◽  
M. M. Najafabadi ◽  
M. Mirlohi ◽  
L. Azadbakht
Keyword(s):  
Oxidative Stress ◽  
Diabetic Patients ◽  
Milk Consumption ◽  
Soy Milk ◽  
Type 2 Diabetic Patients ◽  
And Oxidative Stress ◽  
Type 2 Diabetic
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